CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1293
Family Name Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family
No. of Seeds 47 No. of Other Members 54
Family Centroid CFAMM00234695 Functional Category Investigative Drug with Natural Product
Superfamily Insulin-degrading enzyme inhibitor Bacitracin, Renin inhibitor Remikiren Superfamily
Class Class 414

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Epidermal Growth Factor family 111 209
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
Reverse transcriptase Inhibitor Delavirdine Family 1 68
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Insulin receptor Ligand Insulin, Porcine Family 61 205
HIV-1 protease Inhibitor Atazanavir Family 16 58
Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitrac... 30 259
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Renin Inhibitor Remikiren Family 100 126
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
Prothrombin Inhibitor Dabigatran Family 7 182
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
NS5A protein Inhibitor Bms 790052 Family 5 9
BIBT986 family 7 96
CBP-501 family 7 8
AEZS-108 family 5 2
CP-18770 family 6 27
Gonadotropin-releasing hormone Inhibitor ASP3550 Family 33 60
Eluxadoline family 4 85
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Renin Inhibitor Enalkiren Family 56 44
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Caspase-9 Inhibitor Z-lehd-fmk Family 1 0
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-his-agly-ile-v... 3 2
Glycylpeptide N-tetradecanoyltransferase Inhibitor SC-58272 Fa... 2 11
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Type-2 angiotensin II receptor Ligand PD-123319 Family 3 39
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Pol polyprotein inhibitor AC1LAD48 family 19 5
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Pol polyprotein inhibitor penicillin deriv. 71 family 1 2
Pol polyprotein and Protease inhibitor 161186-52-3 family 3 3
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Bombesin receptor subtype-3 ligand SureCN3515839 family 1 0
Renin and Cathepsin D inhibitor tert-butyl N-[(2R)-1-[[3-[[(2R... 19 4
Renin and Pepsin A inhibitor tert-butyl N-[(2S)-1-[[2-[[(4S,5S... 4 0
Pol polyprotein inhibitor AC1LAQE0 family 13 4
Cholecystokinin receptor type A ligand A-65186 family 2 6
Pol polyprotein inhibitor Hydroxyethylene deriv. 12 family 13 10
Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H... 6 2
Pol polyprotein inhibitor N-[(2S)-1-[[(2S,3R,4S,5S)-3,4-dihydr... 2 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Pol polyprotein inhibitor (2S)-4-(1H-benzimidazol-2-ylmethyl)-... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 11 22
Pol polyprotein inhibitor (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5... 2 0
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Prolyl endopeptidase inhibitor SureCN8938520 family 2 1
Pol polyprotein inhibitor AC1LA3L0 family 3 2
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Integrin alpha-4 inhibitor AC1O7HJM family 3 0
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Lysosomal Pro-X carboxypeptidase inhibitor N-[(2S)-1-[(2S)-2-(... 1 0
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 1 1
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Renin inhibitor propan-2-yl (3R)-2-hydroxy-3-[[(2S)-3-(1H-imid... 4 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 1
Prostaglandin D2 receptor 2 ligand SureCN2215286 family 7 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Pol polyprotein and Renin inhibitor U-75875 family 12 1
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Pol polyprotein inhibitor N-[(3R,4R,5R)-5-[[(2S)-1-(1H-benzimi... 5 4
Endothelin-1 receptor and Endothelin B receptor ligand SureCN9... 3 10
Baculoviral IAP repeat-containing protein 2 and Baculoviral IA... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Renin inhibitor (3R)-4-[[(2S,5S)-1-cyclohexyl-3-hydroxy-6-meth... 3 4
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
Pol polyprotein inhibitor (2R,3R,4R,5S)-5-[[(2S)-2-[5-[(4R,6aS... 1 0
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
C-C chemokine receptor type 5 ligand SureCN13543564 family 10 3
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Coagulation factor X inhibitor SureCN8289965 family 4 5
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 11 0
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Relaxin-3 receptor 1 and Relaxin-3 receptor 2 ligand CHEMBL203... 4 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Melanocortin receptor 4 and Melanocortin receptor 5 ligand CHE... 1 0
C-C chemokine receptor type 5 ligand (2R)-2-[(3S,4S)-3-[[4-(2-... 5 0
C-C chemokine receptor type 5 ligand AC1MHRXO family 5 1
Growth hormone secretagogue receptor type 1 ligand SureCN36660... 4 14
Renin inhibitor AGN-PC-073MLF family 7 6
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5S)-5-(... 2 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1-phenylimidaz... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Somatostatin receptor type 3 and Somatostatin receptor type 4 ... 5 1
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Gastrin/cholecystokinin type B receptor ligand CHEMBL2386886 f... 1 0
Renin inhibitor (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-d... 3 0
Integrin beta-1 and Integrin alpha-4 inhibitor (5R)-5-[[(2R)-2... 2 3
Melanocortin receptor 4 ligand CHEMBL2415084 family 3 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Renin inhibitor (2S)-N-[(2S,3S)-1-cyclohexyl-3-hydroxy-5-(3-im... 4 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 4
Orexin receptor type 2 and Orexin receptor type 1 ligand (2S)-... 2 2
Renin inhibitor (4S)-5-cyclohexyl-2,2-difluoro-4-[[(2S)-3-(1H-... 1 0
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Renin inhibitor AGN-PC-002JXB family 14 0
Gastrin-releasing peptide receptor ligand (2S)-N-[(2S)-1-[[(2S... 1 0
Proteinase-activated receptor 1 and Prothrombin ligand (2S)-N-... 3 23
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Endothelin B receptor and Endothelin-1 receptor ligand 2-[[(2R... 17 10
Growth factor receptor-bound protein 2 ligand 2-[4-[(2S)-3-[[1... 1 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
5-hydroxytryptamine receptor 1D ligand N-[4-[[5-[[3-(2-aminoet... 8 7
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R,2S)-3-cycl... 3 0
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Pol polyprotein and Protease inhibitor 161186-51-2 family 5 0
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-N-(3-imidazo... 1 0
Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R... 5 3
Renin inhibitor tert-butyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl-3,4... 2 2
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 3
Renin inhibitor [(2S)-1-[[(2R)-1-[[(2S,3S)-1-cyclohexyl-3-hydr... 1 0
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
KiSS-1 receptor ligand SureCN5132924 family 2 4
Thromboxane-A synthase inhibitor AGN-PC-00NE8C family 2 3
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(2,4-difluor... 5 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Melanocortin receptor 3 and Melanocyte-stimulating hormone rec... 2 3
Growth hormone secretagogue receptor type 1 ligand CHEMBL52599... 1 0
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 1 0
Substance-P receptor ligand methyl 6-acetamido-3-[[(2S)-1-[[3,... 1 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand CHE... 1 1
Prolyl endopeptidase inhibitor 4-phenyl-1-[(2S,4S)-4-(4-pyridi... 2 1
Tyrosine-protein kinase JAK2 inhibitor SureCN2601181 family 2 2
Putative NP ZINC40309668 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00234684 CHEMBL2028947 Bioactive [4-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(4S,7S)-5-hydroxy-2,8-dimethyl-7-[[(2S,3S)-3-methyl-1-[(1-oxidopyridin-1-ium-2-yl)methylamino]-1-oxopentan-2-yl]carbamoyl]nonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-oxobutyl] dihydrogen phosphate
CFAMM00234624 CHEMBL1790495 Bioactive (2S)-1-N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]-2-N-[(2S)-1-[[(2S)-1-[[(4S,5S,7S)-5-hydroxy-2,8-dimethyl-7-[[(2S,3S)-3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]carbamoyl]nonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-1,2-dicarboxamide
CFAMM00234637 CHEMBL408878 Bioactive AGN-PC-002LXU
CFAMM00234651 CHEMBL318388 Bioactive (2S)-1-[(2S)-2-acetamido-3-(1-formylindol-3-yl)propanoyl]-N-[(2S)-1-[[(2S)-1-[[1-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00234657 CHEMBL410067 Bioactive pyridin-2-ylmethyl (2S,3S)-2-[[(2R,4S,5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-1-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]carbamoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]-methylamino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-hydroxy-7-methyl-2-propan-2-yloctanoyl]amino]-3-methylpentanoate
CFAMM00234610 CHEMBL362209 Bioactive tert-butyl (2S)-2-[[(2S)-1-[[(2S)-1-[[5-hydroxy-2,8-dimethyl-7-[[(2S,3S)-3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]carbamoyl]nonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidine-1-carboxylate
CFAMM00234670 CHEMBL2204329 Bioactive CHEMBL2204329
CFAMM00234636 CHEMBL412950 Bioactive AC1L2AC4
CFAMM00234650 CHEMBL437871 Bioactive sodium;2-[[8-[[1-[[1-[[5-hydroxy-2,8-dimethyl-7-[[3-methyl-1-[(1-oxidopyridin-1-ium-2-yl)methylamino]-1-oxopentan-2-yl]carbamoyl]nonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-8-oxooctanoyl]-methylamino]ethanesulfonate
CFAMM00234663 CHEMBL317280 Bioactive (2S)-1-[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]-N-[(2S)-1-[[(2S)-1-[[(4S)-1-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00234676 CHEMBL336941 Bioactive (2R,5S)-6-cyclohexyl-3,4-dihydroxy-5-[[2-[(2-hydroxyacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-N-[(2S,3R)-3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]-2-propan-2-ylhexanamide
CFAMM00234616 CHEMBL57121 Bioactive tert-butyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-3-hydroxy-6-methyl-1-[[(2S,3S)-3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]amino]-1-oxoheptan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
CFAMM00234629 CHEMBL1237141 Bioactive tert-butyl (2S)-2-[[1-[[1-[[2-hydroxy-5-methyl-1-[[3-methyl-1-[[3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]amino]-1-oxobutan-2-yl]amino]hexan-3-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]-2-methylpyrrolidine-1-carboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid
CFAMM00234656 CHEMBL423968 Bioactive AGN-PC-002LXS
CFAMM00234682 CHEMBL2028948 Bioactive sodium;2-[[8-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(4S,7S)-5-hydroxy-2,8-dimethyl-7-[[(2S,3S)-3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]carbamoyl]nonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-8-oxooctanoyl]-methylamino]ethanesulfonate
CFAMM00234675 CHEMBL383792 Bioactive sodium;2-[[8-[[1-[[1-[[5-hydroxy-2,8-dimethyl-7-[[3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]carbamoyl]nonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-8-oxooctanoyl]-methylamino]ethanesulfonate
CFAMM00234628 CHEMBL1790493 Bioactive tert-butyl (2S)-2-[[(2S)-1-[[(2S)-1-[[(4S,5S,7S)-5-hydroxy-2,8-dimethyl-7-[[(2S,3S)-3-methyl-1-[(1-oxidopyridin-1-ium-2-yl)methylamino]-1-oxopentan-2-yl]carbamoyl]nonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidine-1-carboxylate
CFAMM00234688 CHEMBL346701 Bioactive AGN-PC-002LXR
CFAMM00234694 CHEMBL303323 Bioactive AGN-PC-074ENQ
CFAMM00234608 CHEMBL160448 Bioactive [4-[2-[[1-[[1-[[5-hydroxy-2,8-dimethyl-7-[[3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]carbamoyl]nonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-oxobutyl] dihydrogen phosphate
CFAMM00234621 CHEMBL305382 Bioactive AGN-PC-074E3H
CFAMM00234634 CHEMBL264524 Bioactive (2S)-1-N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]-2-N-[(2S)-1-[[(2S)-1-[[(4S,5S,7S)-5-hydroxy-2,8-dimethyl-7-[[(2S)-3-methyl-1-[(1-oxidopyridin-1-ium-2-yl)methylamino]-1-oxopentan-2-yl]carbamoyl]nonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-1,2-dicarboxamide
CFAMM00234614 CHEMBL414795 Bioactive (2S)-2-N-[(2S)-1-[[(2S)-1-[[(4S,5S,7R)-5-hydroxy-2,8-dimethyl-7-[[(2S,3S)-3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]carbamoyl]nonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]-1-N-[(2S,3R,4R,5R,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]pyrrolidine-1,2-dicarboxamide
CFAMM00234701 CHEMBL404990 Bioactive AGN-PC-002LXT
CFAMM00234654 CHEMBL415615 Bioactive tert-butyl (2S)-2-[[(2S)-1-[[(2S)-1-[[(4S,5S,7R)-5-hydroxy-2,8-dimethyl-7-[[(2S,3S)-3-methyl-1-oxo-1-(pyridin-2-ylmethoxy)pentan-2-yl]carbamoyl]nonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidine-1-carboxylate
CFAMM00234626 CHEMBL1790497 Bioactive Ditekiren
CFAMM00234639 CHEMBL287717 Bioactive tert-butyl N-[1-[[1-[[(3S,4S)-3-hydroxy-6-methyl-1-[[3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]amino]-1-oxoheptan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
CFAMM00234686 CHEMBL2028945 Bioactive sodium;2-[[8-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(4S,7S)-5-hydroxy-2,8-dimethyl-7-[[(2S,3S)-3-methyl-1-[(1-oxidopyridin-1-ium-2-yl)methylamino]-1-oxopentan-2-yl]carbamoyl]nonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-8-oxooctanoyl]-methylamino]ethanesulfonate
CFAMM00234700 CHEMBL2062122 Bioactive (2S)-1-acetyl-N-[(2S)-1-[[(2S)-1-[[(4S,5S,7S)-7-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]carbamoyl]-5-hydroxy-2,8-dimethylnonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00234653 CHEMBL347952 Bioactive tert-butyl (2S)-2-[[1-[[1-[[3-hydroxy-6-methyl-1-[[3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]amino]-1-oxoheptan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]-2-methylpyrrolidine-1-carboxylate
CFAMM00234606 CHEMBL151953 Bioactive tert-butyl (2S)-2-[[1-[[1-[[2-hydroxy-5-methyl-1-[[3-methyl-1-[[3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]amino]-1-oxobutan-2-yl]amino]hexan-3-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]-2-methylpyrrolidine-1-carboxylate
CFAMM00234619 CHEMBL100924 Bioactive (2S)-1-[(2S)-2-acetamido-3-(1-formylindol-3-yl)propanoyl]-N-[(2S)-1-[[(2S)-1-[(1-amino-3-hydroxy-6-methyl-1-oxoheptan-4-yl)amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00234632 CHEMBL166640 Bioactive tert-butyl N-[(2S)-1-[[(2S,3S,5S)-1-cyclohexyl-3-hydroxy-6-methyl-5-[[(2S)-3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]carbamoyl]heptan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamate
CFAMM00234612 CHEMBL2070243 Bioactive (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(3S,12S,15S,18S,21R,24S,26R)-21-benzyl-12-carbamoyl-18-[3-(diaminomethylideneamino)propyl]-26-hydroxy-15-(1H-indol-3-ylmethyl)-2,6,14,17,20,23-hexaoxo-1,7,13,16,19,22-hexazabicyclo[22.3.0]heptacosan-3-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-2-[[(2S)-2-[[2-(hexadecanoylamino)acetyl]amino]-3-hydroxypropanoyl]amino]pentanediamide
CFAMM00234659 CHEMBL429882 Bioactive (2S)-1-N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]-2-N-[(2S)-1-[[(2S)-1-[[(4S,5S,7R)-5-hydroxy-2,8-dimethyl-7-[[(2S,3S)-3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]carbamoyl]nonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-1,2-dicarboxamide
CFAMM00234672 CHEMBL320414 Bioactive (2S)-1-[(2S)-2-acetamido-3-(1-formylindol-3-yl)propanoyl]-N-[(2S)-1-[[(2S)-1-[[(4S,7S)-7-carbamoyl-5-hydroxy-2,8-dimethylnonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00234685 CHEMBL2028946 Bioactive [2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(4S,7S)-5-hydroxy-2,8-dimethyl-7-[[(2S,3S)-3-methyl-1-[(1-oxidopyridin-1-ium-2-yl)methylamino]-1-oxopentan-2-yl]carbamoyl]nonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl] dihydrogen phosphate
CFAMM00234699 CHEMBL2062123 Bioactive (2R)-1-acetyl-N-[(2S)-1-[[(2S)-1-[[(4S,5S,7S)-7-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]carbamoyl]-5-hydroxy-2,8-dimethylnonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00234652 CHEMBL1790553 Bioactive (2R,3R,4R,5S)-6-cyclohexyl-3,4-dihydroxy-5-[[(2S)-2-[(2-hydroxyacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-N-[(2S,3R)-3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]-2-propan-2-ylhexanamide
CFAMM00234678 CHEMBL160428 Bioactive AGN-PC-002LXL
CFAMM00234669 DNC004093 Investigative Drug PP1-Pro-Phe-N-MeHis-LVA-Ile-Amp-(O)
CFAMM00234695 DNC004086 Investigative Drug Sul-Pro-Phe-N-MeHis-LVA-Ile-Amp
CFAMM00234655 DNC004071 Investigative Drug PP2-Pro-Phe-N-MeHis-LVA-Ile-Amp-(O)

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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