CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1294
Family Name Cyclin-dependent kinase 1 and Cyclin-dependent kinase 5 Inhibitor Kenpaullone Family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00234709 Functional Category Investigative Drug
Superfamily Cyclin-dependent kinase 1 and Cyclin-dependent kinase 5 Binder Superfamily
Class Class 59

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Lethal factor Inhibitor GM6001 Family 50 435
Cyclin-dependent kinase 5 Inhibitor 9-nitropaullone Family 2 13
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Dihydroorotate dehydrogenase Inhibitor Nsc 665564 Family 2 83
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Serine/threonine-protein kinase Chk1 inhibitor SureCN5551829 f... 1 14
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 1
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 1 0
Cytochrome P450 2C9 inhibitor AGN-PC-04XDND family 1 3
Vascular endothelial growth factor receptor 2 ligand 3-[2-[(Z)... 1 3
Serine/threonine-protein kinase Chk1 inhibitor SureCN6080935 f... 1 0
Protein-glutamine gamma-glutamyltransferase 2 inhibitor SureCN... 2 2
Putative NP ZINC20763633 Family 16 1
9H-pyrido[3,4-b]indole-3-carboxamide NP (1-(3-bromophenyl)-9h-... 5 0


External ID

Functional Category

Molecule Name

CFAMM00234706 DNC004083 Investigative Drug AZAKENPAULLONE
CFAMM00234709 DNC004072 Investigative Drug KENPAULLONE

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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