CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID13
Family Name 72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhibitor IK-682 Family
No. of Seeds 37 No. of Other Members 265
Family Centroid CFAMM00174190 Functional Category Investigative Drug with Natural Product
Superfamily Sodium channel protein type 5 subunit alpha Ligand Dibucaine Superfamily
Class Class 297

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Phospholipase A2 Inhibitor Quinacrine Family 13 95
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Arachidonate 5-lipoxygenase Inhibitor MK-591 Family 9 161
Mast/stem cell growth factor receptor Kit and Vascular endothe... 1 4
Coagulation factor X Inhibitor Apixaban Family 34 52
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Turofexorate Isopropyl family 6 29
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Integrin beta-3 Inhibitor L-756568 Family 8 59
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
High affinity nerve growth factor receptor and Mitogen-activat... 2 7
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... 2 2
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Cannabinoid receptor 1 and 5-hydroxytryptamine receptor 1A lig... 2 12
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
Muscarinic acetylcholine receptor M2 and Acetylcholinesterase ... 4 24
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Renin inhibitor SureCN1144364 family 3 15
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Histamine H3 receptor ligand (4S)-7-bromo-4-methyl-8-(1-propan... 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Renin inhibitor AGN-PC-09M9MJ family 2 23
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 5
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Disintegrin and metalloproteinase domain-containing protein 17... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 5
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Coagulation factor X and Anionic trypsin-2 inhibitor AGN-PC-07... 1 1
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Arachidonate 5-lipoxygenase inhibitor (2E)-2-[2-butyl-1-[4-(qu... 1 12
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 3
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 16 5
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Coagulation factor X and Prothrombin inhibitor 6-[4-[2-[[(3R)-... 15 2
Prostaglandin D2 receptor 2 ligand SureCN2189431 family 7 1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor N-hydro... 3 25
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Disintegrin and metalloproteinase domain-containing protein 17... 44 12
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Renin inhibitor [2-(2,6-dimethylphenoxy)-6-methoxy-1-phenylpyr... 1 0
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 3 4
Collagenase 3 and Interstitial collagenase inhibitor (2R,5R)-N... 4 1
NS5B protein inhibitor AC1O5AET family 3 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-... 4 8
Renin and Potassium voltage-gated channel subfamily H member 2... 4 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Disintegrin and metalloproteinase domain-containing protein 17... 1 2
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Matrix metalloproteinase-9 and Collagenase 3 inhibitor 5-[4-(6... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(4-fluo... 7 1
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Sonic hedgehog protein inhibitor 3-methoxy-1-methyl-4-oxo-5-ph... 5 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 7-met... 3 2
Microsomal triglyceride transfer protein large subunit inhibit... 9 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cholinesterase and Acetylcholinesterase inhibitor tacrine deri... 10 0
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... 3 0
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy... 12 6
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Cannabinoid receptor 1 ligand AGN-PC-0766FR family 4 3
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Translocator protein inhibitor AGN-PC-07BUUF family 11 2
Cholinesterase and Acetylcholinesterase inhibitor 6-[4-[2-fluo... 17 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 1 0
C-C chemokine receptor type 5 ligand N-methyl-4-[6-methyl-5-[[... 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 19 11
Disintegrin and metalloproteinase domain-containing protein 17... 5 0
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 8 0
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... 3 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 7-met... 2 1
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
D(2) dopamine receptor ligand SureCN10575660 family 1 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Substance-P receptor ligand SureCN2139814 family 7 7
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Matrix metalloproteinase-9 and Collagenase 3 inhibitor AGN-PC-... 1 3
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 1
Vasopressin V2 receptor ligand SureCN4400636 family 1 0
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Disintegrin and metalloproteinase domain-containing protein 17... 9 0
Histamine H3 receptor ligand SureCN1397929 family 1 1
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-[3-(dimethylamino)... 106 49
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
P2Y purinoceptor 12 inhibitor (4S)-5-oxo-5-(4-pentoxycarbonylp... 5 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Prothrombin inhibitor AGN-PC-074I2Z family 2 1
Pol polyprotein inhibitor N-benzyl-2,2-difluoro-4-[[(2S)-3-met... 1 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-[2-[2-(dimethylamino)et... 2 0
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
NS3 and Non-structural protein 4A inhibitor 4-[2-[[(2S)-2-[[(2... 2 0
Potassium voltage-gated channel subfamily A member 5 ligand AG... 1 0
Tyrosine-protein kinase JAK3 and Activated CDC42 kinase 1 inhi... 4 1
Phospholipase A2, membrane associated inhibitor 2-(1-benzyl-2-... 2 1
Bile acid receptor ligand SureCN1243717 family 1 4
Telomerase reverse transcriptase inhibitor N-[9-(4-methoxyanil... 2 0
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 3 0
Oxysterols receptor LXR-beta ligand indole derivative, 39 family 2 0
Pol polyprotein inhibitor Phenprocoumon IndolEtCONH deriv. family 2 0
NP (7,8-dimethoxy-3-methyl-2,3-dihydro-1h-benzo[d]azepin-4-yl)... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00173969 CHEMBL429589 Bioactive (3S,4S)-N-hydroxy-1-methyl-4-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]pyrrolidine-3-carboxamide
CFAMM00173918 CHEMBL379469 Bioactive N-hydroxy-2-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-1,1-dioxo-1,2,5-thiadiazolidine-3-carboxamide
CFAMM00173947 CHEMBL404162 Bioactive (3S,4S)-N-hydroxy-1-(2-methylprop-2-enyl)-4-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]pyrrolidine-3-carboxamide
CFAMM00174178 CHEMBL417212 Bioactive butyl N-[(1S)-2-(hydroxyamino)-1-[(3R)-1-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-3-yl]-2-oxoethyl]carbamate
CFAMM00173939 CHEMBL336832 Bioactive (2S,3S)-1-(cyclopropylmethyl)-3-N-hydroxy-2-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]piperidine-2,3-dicarboxamide
CFAMM00174029 CHEMBL443884 Bioactive (1S,2R)-2-[(3R)-3-(dimethylamino)pyrrolidine-1-carbonyl]-N-hydroxy-2-[[4-[(2-phenylquinolin-4-yl)methoxy]phenyl]methyl]cyclopropane-1-carboxamide
CFAMM00174120 CHEMBL60373 Bioactive methyl N-[(1S)-2-(hydroxyamino)-1-[(3R)-1-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-3-yl]-2-oxoethyl]carbamate
CFAMM00174073 CHEMBL270819 Bioactive (3S,4S)-N-hydroxy-1-(2-methylpropanoyl)-4-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]pyrrolidine-3-carboxamide
CFAMM00174086 CHEMBL496527 Bioactive (2R,3R)-3-N-hydroxy-1-methyl-2-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]piperidine-2,3-dicarboxamide
CFAMM00174001 CHEMBL62964 Bioactive (2S)-2-acetamido-N-hydroxy-2-[(3R)-1-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-3-yl]acetamide
CFAMM00174028 CHEMBL303370 Bioactive (2S)-2-(dimethylamino)-N-hydroxy-2-[(3R)-1-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-3-yl]acetamide
CFAMM00174105 CHEMBL337849 Bioactive (2S,3S)-1-ethyl-3-N-hydroxy-2-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]piperidine-2,3-dicarboxamide
CFAMM00174044 CHEMBL183791 Bioactive (2S,3S)-3-N-methoxy-1-methyl-2-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]piperidine-2,3-dicarboxamide
CFAMM00173916 CHEMBL245339 Bioactive (2S)-N-hydroxy-2-[(3R)-3-methyl-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]propanamide
CFAMM00174007 CHEMBL303983 Bioactive tert-butyl N-[(1S)-2-(hydroxyamino)-1-[(3R)-1-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-3-yl]-2-oxoethyl]carbamate
CFAMM00174035 CHEMBL270800 Bioactive (3S,4S)-N-hydroxy-4-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]-1-prop-2-enylpyrrolidine-3-carboxamide
CFAMM00174168 CHEMBL524072 Bioactive (1R,2S)-2-N-hydroxy-1-N,1-N-dimethyl-1-[[4-[(2-phenylquinolin-4-yl)methoxy]phenyl]methyl]cyclopropane-1,2-dicarboxamide
CFAMM00174069 CHEMBL1630098 Bioactive (2R)-2-[(3R)-3-amino-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]-N-hydroxy-3-methylbutanamide
CFAMM00174109 CHEMBL63272 Bioactive (2S)-N-hydroxy-2-[(3R)-1-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-3-yl]propanamide
CFAMM00174039 CHEMBL302002 Bioactive 2-[(3S)-3-amino-1-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-3-yl]-N-hydroxyacetamide
CFAMM00174115 CHEMBL64586 Bioactive (2S)-2-amino-N-hydroxy-2-[(3R)-1-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-3-yl]acetamide
CFAMM00174193 CHEMBL409891 Bioactive hydroxamate deriv., 80
CFAMM00174068 CHEMBL524092 Bioactive N-hydroxy-2-[(3R)-3-methyl-1-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-3-yl]acetamide
CFAMM00174145 CHEMBL64281 Bioactive N-hydroxy-N-[(1S)-1-[(3R)-1-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-3-yl]ethyl]formamide
CFAMM00173912 CHEMBL256245 Bioactive (3S,4S)-1-benzyl-N-hydroxy-4-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]pyrrolidine-3-carboxamide
CFAMM00174108 CHEMBL467798 Bioactive (1S,2R)-2-[(3S)-3-(dimethylamino)pyrrolidine-1-carbonyl]-N-hydroxy-2-[[4-[(2-phenylquinolin-4-yl)methoxy]phenyl]methyl]cyclopropane-1-carboxamide
CFAMM00174122 CHEMBL417411 Bioactive (2S)-2-[(3S)-3-amino-1-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-3-yl]-N-hydroxypentanamide
CFAMM00174114 CHEMBL305163 Bioactive (2S)-2-[(3S)-3-amino-1-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-3-yl]-N-hydroxypropanamide
CFAMM00173948 CHEMBL403401 Bioactive (3S,4S)-N-hydroxy-4-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]-1-propan-2-ylpyrrolidine-3-carboxamide
CFAMM00173961 CHEMBL432333 Bioactive N-[(1S)-2-(hydroxyamino)-1-[(3R)-1-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-3-yl]-2-oxoethyl]-2,2-dimethylpropanamide
CFAMM00174024 CHEMBL252892 Bioactive (3S,4S)-1-[2-(dimethylamino)ethyl]-N-hydroxy-3-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]piperidine-4-carboxamide
CFAMM00173897 CHEMBL341380 Bioactive (2S,3S)-3-N-hydroxy-2-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]piperidine-2,3-dicarboxamide
CFAMM00174081 CHEMBL401979 Bioactive (3S,4S)-1-acetyl-N-hydroxy-4-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]pyrrolidine-3-carboxamide
CFAMM00174190 DNC003728 Investigative Drug IK-682
CFAMM00174154 DPR000038 Investigative Drug DPC-333
CFAMM00173928 DNC014796 Investigative Drug IM-491

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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