CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1311
Family Name Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic Acid Hydroxyamide Family
No. of Seeds 7 No. of Other Members 13
Family Centroid CFAMM00235249 Functional Category Investigative Drug
Superfamily Cathepsin K and Cathepsin L1 Binder Superfamily
Class Class 2062

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Vasopressin V1a receptor Ligand Felypressin Family 12 820
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Sodium channel protein type 1 subunit alpha Ligand Phenacemide... 5 6
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
DNA Binder Procarbazine Family 8 358
Noradrenergic re-uptake Inhibitor Milnacipran Family 7 51
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Motilin receptor Ligand GSK962040 Family 30 457
C-X-C chemokine receptor type 1 and C-X-C chemokine receptor t... 5 30
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Aldose reductase Inhibitor Alrestatin Family 2 11
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-4-isobutyl-ben... 4 43
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-bi... 5 14
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 1 3
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Thyroid hormone receptor beta Ligand 1-(4-hexylphenyl)-3-(prop... 2 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropy... 2 7
Poly [ADP-ribose] polymerase 1 Inhibitor 5-aminoisoquinolin-1(... 2 8
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Histone deacetylase 1 Inhibitor N-hydroxy-6-oxo-6-phenylhexana... 7 7
Histone deacetylase 1 Inhibitor N-hydroxy-7-(naphthalen-2-yl)-... 3 2
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmethylma... 2 2
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-137546 Family 1 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-2-nap... 3 3
Arachidonate 5-lipoxygenase Inhibitor Phenanthrene-3-carboxyli... 7 4
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-2,3,3... 1 0
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Aminopeptidase N Inhibitor 2-amino-n1-benzyl-n3-hydroxymalonam... 3 4
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
DNA topoisomerase Inhibitor 6-benzylamino-1h-pyrimidine-2,4-di... 3 3
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 3
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
Peptide deformylase inhibitor (2R)-N-[(2S)-1-(4-fluorophenyl)-... 4 0
Peptide deformylase inhibitor (2R)-2-[[formyl(hydroxy)amino]me... 2 1
Acetylcholinesterase inhibitor AC1MIM21 family 2 7
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Metabotropic glutamate receptor 5 ligand SureCN504295 family 1 7
Neutrophil collagenase and Collagenase 3 inhibitor n-[[2-methy... 1 4
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Peptide deformylase inhibitor (2S)-N-benzoyl-1-[(2R)-2-(cyclop... 2 2
Dipeptidyl peptidase 4 inhibitor 4-cyano-N-[4-[(2S)-2-cyanopyr... 1 1
Histamine H3 receptor ligand N-ethyl-3-fluoro-3-[3-fluoro-4-(p... 3 0
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
Prothrombin and Coagulation factor X inhibitor [(1R)-5-amino-1... 2 3
Prothrombin inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethyl... 8 1
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 5
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-[2-[benzoyl... 2 0
Cathepsin S and Cathepsin L1 inhibitor (Z,3S)-1-diazonio-3-[[2... 1 0
Receptor tyrosine-protein kinase erbB-2 and Disintegrin and me... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Interstitial collagenase and 72 kDa type IV collagenase inhibi... 1 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 4
Trypsin-1 and Prothrombin inhibitor N-[(1R)-4-(diaminomethylid... 1 0
Tyrosine-protein kinase Lck inhibitor 1-[2-[bis[3-[bis[3-[bis(... 1 0
Genome polyprotein inhibitor Benzoyl-KKR-H family 1 1
Nuclear receptor ROR-gamma and Putative fructose-1,6-bisphosph... 1 3
DNA polymerase beta and Muscleblind-like protein 1 inhibitor C... 1 0
Putative fructose-1,6-bisphosphate aldolase and Nuclear recept... 1 6
Nonstructural protein 1 inhibitor CHEMBL1582638 family 1 0
Thioredoxin reductase 1, cytoplasmic inhibitor 5-fluoro-2-[2-(... 3 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 3 0
Histone deacetylase 6 inhibitor AGN-PC-0C5HOH family 1 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00235245 DNC004626 Investigative Drug N-[5-(Formyl-hydroxy-amino)-pentyl]-benzamide
CFAMM00235237 DNC004116 Investigative Drug N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide
CFAMM00235236 DNC008012 Investigative Drug N-hydroxy-4-(2-oleamidoethyl)benzamide
CFAMM00235249 DNC010907 Investigative Drug 8-(3-Benzoyl-ureido)-octanoic acid hydroxyamide
CFAMM00235248 DNC010906 Investigative Drug 7-(3-Benzoyl-ureido)-heptanoic acid hydroxyamide
CFAMM00235247 DNC010905 Investigative Drug 6-(3-Benzoyl-ureido)-hexanoic acid hydroxyamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26829 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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