CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1312
Family Name D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741626 Family
No. of Seeds 9 No. of Other Members 73
Family Centroid CFAMM00235274 Functional Category Investigative Drug with Natural Product
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741626 Superfamily
Class Class 2063

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Phospholipase A2 Inhibitor Quinacrine Family 13 95
D(2) dopamine receptor Ligand Sertindole Family 3 173
Food vacuoles Inhibitor Mefloquine Family 2 25
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
5-hydroxytryptamine receptor Ligand Metergolin Family 2 11
DNA Binder Elliptinium Acetate Family 11 116
Citric Acid family 2 58
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
ABC294640 family 5 75
Grt 6005/06 family 4 22
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 5 69
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand (6-ben... 2 5
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
D(1B) dopamine receptor and D(2) dopamine receptor Ligand Flut... 1 6
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 40
Progesterone receptor and Glucocorticoid receptor ligand SureC... 4 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
D(4) dopamine receptor and D(1A) dopamine receptor ligand 2-[[... 5 4
Prostaglandin G/H synthase 2 inhibitor SureCN6998947 family 1 1
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 7 14
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Glucocorticoid receptor ligand SureCN5650626 family 17 25
Glucocorticoid receptor and Progesterone receptor ligand [(3R,... 6 2
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Glucocorticoid receptor ligand AGN-PC-0A9RHA family 1 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 5 3
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Melanin-concentrating hormone receptor 2 ligand (2R)-1'-(9H-ca... 2 10
Melanin-concentrating hormone receptor 2 and Sodium-dependent ... 2 1
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Glucocorticoid receptor ligand 1,1,1-trifluoro-2-[(1-methyl-3,... 3 4
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Transporter and Sodium-dependent serotonin transporter inhibit... 2 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
Transient receptor potential cation channel subfamily V member... 1 5
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
5-hydroxytryptamine receptor 2A ligand (3R,4R)-3-(2-phenyl-1H-... 1 18
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 5 1
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Beta-3 adrenergic receptor ligand 3-[2-[[(2R)-2-(3-chloropheny... 1 1
C-C chemokine receptor type 2 ligand (E)-3-(3,4-dichlorophenyl... 1 3
D(4) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand RU-2... 3 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 5
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Nociceptin receptor and Potassium voltage-gated channel subfam... 3 9
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
Androgen receptor ligand 1-[[6-chloro-5-(hydroxymethyl)pyridin... 2 1
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 4 3
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (2Z)-... 1 0
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00235339 CHEMBL1173285 Bioactive AGN-PC-0886YJ
CFAMM00235283 CHEMBL26393 Bioactive SureCN9435482
CFAMM00235330 CHEMBL523719 Bioactive 3-(3,4-dichlorophenyl)-8-(1H-indol-3-ylmethyl)-8-azabicyclo[3.2.1]octan-3-ol
CFAMM00235310 CHEMBL25133 Bioactive AGN-PC-005OP4
CFAMM00235323 CHEMBL246439 Bioactive SureCN11265940
CFAMM00235275 CHEMBL25823 Bioactive (1R)-1-(3-chlorophenyl)-2-[[(2S)-1-(1H-indol-3-yl)propan-2-yl]amino]ethanol
CFAMM00235315 CHEMBL1170683 Bioactive Ambcb5455946
CFAMM00235267 CHEMBL246637 Bioactive 4-(3,4-dichlorophenyl)-1-(1H-indol-3-ylmethyl)piperidin-4-ol
CFAMM00235274 DNC004117 Investigative Drug L-741626

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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