CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
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CFam Family Information

CFAM Family ID CFFID1315
Family Name Epidermal growth factor receptor Ligand PD-158780 Family
No. of Seeds 98 No. of Other Members 89
Family Centroid CFAMM00235363 Functional Category Investigative Drug
Superfamily Epidermal growth factor receptor and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 202

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Cytochrome P450 3A4 Inhibitor Clotrimazole Family 16 145
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Alpha-2A adrenergic receptor Ligand Brimonidine Family 3 6
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
Histamine H1 receptor Ligand Mizolastine Family 14 603
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
Prothrombin Inhibitor Dabigatran Family 7 182
Transient receptor potential cation channel subfamily V member... 15 158
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Transient receptor potential cation channel subfamily V member... 6 66
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
HER Inhibitor AC480 Family 4 67
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor PF-0048... 2 13
Amg 423 family 7 47
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
GDC-0349 family 44 77
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
SCH-900776 family 8 14
C-Jun N-terminal kinase Inhibitor CC-930 Family 2 9
JAK Inhibitor Momelotinib Family 33 83
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
XL-888 family 16 85
PF-4217903 family 14 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Tryptase Inhibitor Babim Family 12 90
Class II cytokine receptor Ligand IL-10 Family 7 45
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibi... 2 3
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Histamine H3 receptor Ligand SCH79687 Family 11 29
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Peptide deformylase, mitochondrial Inhibitor 5-chloryl-2,4,6-q... 2 6
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Transient receptor potential cation channel subfamily V member... 1 0
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Metabotropic glutamate receptor 5 Ligand 3-(1-pyridin-2-yl-1h-... 3 6
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 4 30
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-aminobenzyl... 3 6
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... 1 6
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Transient receptor potential cation channel subfamily V member... 2 26
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 1-(3-... 2 29
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Aromatase Inhibitor NSC-356781 Family 3 10
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Farnesyl pyrophosphate synthase Inhibitor [2-(benzoimidazol-1-... 2 16
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Macrophage metalloelastase Inhibitor Ageladine A Family 1 0
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 9 16
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Urotensin-2 receptor Ligand Palosuran Family 4 4
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Reverse transcriptase Inhibitor PT-102 Family 8 12
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
5-hydroxytryptamine receptor 1A Ligand CGS-12066B Family 1 0
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Reverse transcriptase Inhibitor PT-109 Family 6 7
Metabotropic glutamate receptor 5 Ligand 2-methyl-7-m-tolyl-1,... 5 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... 2 3
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Metabotropic glutamate receptor 5 Ligand 2-(3-bromophenyl)-7-m... 3 1
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-(2-m-tolylethynyl)p... 7 49
Metabotropic glutamate receptor 5 Ligand 5-(2-(3-chlorophenyl)... 2 13
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Adenosine kinase inhibitor GP683 family 12 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Corticotropin-releasing factor receptor 1 ligand 4-N-(2-bromo-... 9 48
Corticotropin-releasing factor receptor 1 ligand N-(2-bromo-4-... 5 0
Adenosine kinase inhibitor AGN-PC-074UAJ family 3 10
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5854779 family 4 9
Adenosine kinase inhibitor abt-702 family 14 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 8
Prothrombin inhibitor SureCN5856722 family 3 16
Somatostatin receptor type 4 and Glucosylceramidase ligand MLS... 1 16
Corticotropin-releasing factor receptor 1 ligand 3-(2-bromo-4-... 13 34
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 3
Deoxycytidine kinase inhibitor AGN-PC-07Z9B3 family 2 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Aurora kinase A inhibitor AGN-PC-07ZZEH family 2 4
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Bombesin receptor subtype-3 ligand (2R)-1-[4-[2-[5-(2,2-dimeth... 1 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Epidermal growth factor receptor ligand AGN-PC-07Q1HU family 4 17
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase and Potassium vol... 13 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN5... 6 24
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Thromboxane-A synthase inhibitor AGN-PC-00N7V2 family 3 6
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 13
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Adenosine kinase inhibitor 5-[3-(3-bromophenyl)propyl]-6-[2-(6... 3 0
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
Transient receptor potential cation channel subfamily V member... 1 0
Transient receptor potential cation channel subfamily V member... 1 4
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
Histamine H3 receptor ligand SureCN4025673 family 4 2
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Histamine H3 receptor ligand SureCN4018269 family 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Adenosine receptor A3 ligand 5-butyl-8-(4-methylsulfanylphenyl... 2 4
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inh... 7 6
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
S-methyl-5'-thioadenosine phosphorylase inhibitor SureCN997478... 8 0
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
C-X-C chemokine receptor type 4 and Envelope glycoprotein gp16... 2 2
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Epidermal growth factor receptor ligand AGN-PC-076GVG family 8 1
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Cathepsin K and Potassium voltage-gated channel subfamily H me... 3 1
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M46L fa... 2 7
Epidermal growth factor receptor ligand AGN-PC-076GXM family 6 0
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Vascular endothelial growth factor receptor 2 and Mitogen-acti... 2 2
Survival motor neuron protein and Menin inhibitor CHEMBL132797... 1 1
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Sorbitol dehydrogenase inhibitor SureCN6335187 family 2 6
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 2
Prelamin-A/C and Lethal(3)malignant brain tumor-like protein 1... 1 1
Prothrombin and Trypsin-1 inhibitor SureCN12636557 family 9 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14574... 1 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor AC1LAKQL family 3 1
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Dihydrofolate reductase inhibitor AC1LAKWV family 2 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Adenosine kinase inhibitor SureCN8183719 family 2 3
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 2 2
Epidermal growth factor receptor ligand AGN-PC-07C2E2 family 7 6
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Survival motor neuron protein inhibitor CHEMBL1581561 family 1 3
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Adenosine receptor A3 and Adenosine receptor A1 ligand (8R)-8-... 4 0
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Tyrosine-protein kinase JAK3 inhibitor N-methyl-N-[(1S,5S)-2-m... 2 12
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 5 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Corticotropin-releasing factor receptor 1 ligand SureCN6301726... 4 1
Insulin-like growth factor 1 receptor and Insulin receptor lig... 1 1
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 5 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 1
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 1 4
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 11 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Hepatocyte growth factor receptor ligand AGN-PC-08XYH0 family 8 4
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 6 0
Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin... 7 6
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 9 3
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
ALK tyrosine kinase receptor and Insulin receptor ligand N-[(1... 3 6
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Metabotropic glutamate receptor 5 ligand SureCN3866791 family 2 10
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(1H-pyr... 2 8
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Sonic hedgehog protein and Smoothened homolog inhibitor N-(4,4... 2 13
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Adenosine deaminase inhibitor AGN-PC-00FYYU family 4 5
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Vascular endothelial growth factor receptor 2 ligand urea deri... 3 9
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 1 1
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Ribosomal protein S6 kinase alpha-5 inhibitor AGN-PC-075HAD fa... 2 0
Vascular endothelial growth factor receptor 2 ligand urea deri... 2 0
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 0
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Transient receptor potential cation channel subfamily V member... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 15 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Vascular endothelial growth factor receptor 2 and Fibroblast g... 5 2
Cyclin-dependent kinase 1 inhibitor 4-[[4-(3H-benzimidazol-5-y... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 1 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Mitogen-activated protein kinase kinase kinase 8 and Dual spec... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 3 0
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 11 3
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Ketohexokinase inhibitor 4-N-(2-methylsulfanylphenyl)-2-pipera... 6 23
Transient receptor potential cation channel subfamily V member... 4 0
Epidermal growth factor receptor ligand (2R,3R)-3-[[4-(3-bromo... 3 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 11 0
Adenosine receptor A2a and Adenosine receptor A2b ligand 6-(2,... 6 1
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 0
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 0
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
Dual specificity protein kinase TTK inhibitor 4-[[2-(2-methyl-... 1 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0074... 2 3
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Acetylcholinesterase and Cholinesterase inhibitor 2-amino-6-[3... 1 4
Transient receptor potential cation channel subfamily V member... 4 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BSP9 ... 6 12
Methionine--tRNA ligase inhibitor N-[(4R)-6,8-dibromo-1,2,3,4-... 1 1
Fibroblast growth factor receptor 1 and Vascular endothelial g... 5 0
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Smoothened homolog inhibitor N-[4-chloro-3-(5-phenyl-1H-imidaz... 4 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Sigma non-opioid intracellular receptor 1 ligand 1-(3,4-dichlo... 2 19
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Metabotropic glutamate receptor 2 ligand 3-(cyclopropylmethyl)... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 4 8
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206058 family 5 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 0
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Adenosine kinase inhibitor 5-(4-bromophenyl)-6-[2-[4-(dimethyl... 1 0
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 5
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Tyrosine-protein kinase JAK1 and Aurora kinase A inhibitor CHE... 2 0
Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... 3 0
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Dipeptidyl peptidase 4 and Seprase inhibitor (1S,5S)-5-[3-(tri... 1 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Motilin receptor ligand SureCN2004322 family 2 1
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 5
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1... 1 0
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cathepsin K inhibitor SureCN4141224 family 3 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 5
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Cathepsin K and Cathepsin L1 inhibitor 5-[3-(3,4-dihydro-1H-is... 2 0
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-[3-(4-piperidi... 2 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Epidermal growth factor receptor ligand AGN-PC-076GWD family 2 0
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 22
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 14 14
Dihydrofolate reductase type 1 and Dihydrofolate reductase inh... 2 0
Epidermal growth factor receptor ligand AGN-PC-078X7L family 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor ligand (E)-N-[4-(3-bromoanili... 2 1
Epidermal growth factor receptor ligand N-[4-(3-bromoanilino)-... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03IU3J family 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
Adenosine kinase inhibitor SureCN8248615 family 2 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Nociceptin receptor and Mu-type opioid receptor ligand SureCN5... 1 0
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 4 0
Epidermal growth factor receptor ligand 4-Anilinopyrido[3,4-d]... 2 0
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 1 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 3 0
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Type-1 angiotensin II receptor ligand AGN-PC-04X8EF family 1 1
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Epidermal growth factor receptor ligand (E)-1-[4-(3-bromoanili... 9 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Serine/threonine-protein kinase B-raf inhibitor imidazole-base... 2 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Mitogen-activated protein kinase 8 inhibitor N-[4-[4-[2-(cyclo... 1 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Prostaglandin E synthase inhibitor AGN-PC-014WPB family 1 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-b]pyridazine d... 2 1
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
D(2) dopamine receptor ligand 4-bromo-6-[2-[4-[3-(trifluoromet... 1 2
Epidermal growth factor receptor ligand AGN-PC-078X9P family 4 0
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Transient receptor potential cation channel subfamily V member... 3 2
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... 1 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Bifunctional epoxide hydrolase 2 and Potassium voltage-gated c... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-[3-(2-hydroxyeth... 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family 7 0
Tyrosine-protein kinase ZAP-70 inhibitor AGN-PC-07CO7Z family 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
C-C chemokine receptor type 5 ligand AC1MHPAK family 5 1
Rho-associated protein kinase 1 inhibitor AGN-PC-07COKD family 1 0
Dihydrofolate reductase type 1 and Dihydrofolate reductase inh... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Adenosine kinase inhibitor AGN-PC-074DKZ family 1 0
Dihydrofolate reductase inhibitor 5-[(7-chloro-10-methylsulfan... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Tyrosine-protein kinase Lck and Tyrosine-protein kinase Lyn in... 1 0
Reverse transcriptase/RNaseH inhibitor 181305-52-2 family 1 0
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
Nitric oxide synthase, inducible inhibitor N-(3-chlorophenyl)-... 1 0
Cytochrome P450 1A2 inhibitor AGN-PC-0BTGP4 family 1 0
Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(c... 2 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Prostaglandin E synthase inhibitor 7-bromo-2-(2-chlorophenyl)-... 3 2
Metabotropic glutamate receptor 5 ligand 2-[4-(4-fluoro-3-meth... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 0
Tyrosine-protein kinase Lck inhibitor N-(2-bromophenyl)imidazo... 1 0
Aromatase inhibitor AGN-PC-073MJQ family 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 0
Dihydrofolate reductase inhibitor 5-[(4-amino-3,5-dibromopheny... 1 0
Epidermal growth factor receptor ligand AGN-PC-075SGM family 1 1
Hepatocyte growth factor receptor ligand AGN-PC-050CDR family 1 0
Coagulation factor X and Prothrombin inhibitor SureCN6578740 f... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name
CFAMM00235352 CHEMBL136102 Bioactive 4-Anilinopyrido[3,4-d]pyrimidine 30
CFAMM00235472 CHEMBL355816 Bioactive PD158780 Analog 5x
CFAMM00235485 CHEMBL139044 Bioactive 4-Anilinopyrido[3,4-d]pyrimidine 14
CFAMM00235444 CHEMBL129825 Bioactive pyrido[4,3-d]pyrimidine deriv. 3n
CFAMM00235362 CHEMBL53156 Bioactive Pyrido[3,2-d]pyrimidine 11f
CFAMM00235377 CHEMBL398334 Bioactive SureCN14561539
CFAMM00235487 CHEMBL437890 Bioactive AGN-PC-00CO78
CFAMM00235365 CHEMBL54091 Bioactive N-[4-(3-bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]prop-2-enamide
CFAMM00235500 CHEMBL52591 Bioactive 4-anilinopyrimido[5,4-d]pyrimidine deriv. 6c
CFAMM00235465 CHEMBL165864 Bioactive PD158780 Analog 5d
CFAMM00235493 CHEMBL162622 Bioactive PD158780 Analog 5n
CFAMM00235434 CHEMBL271328 Bioactive AGN-PC-076GWG
CFAMM00235395 CHEMBL165547 Bioactive PD158780 Analog 5g
CFAMM00235410 CHEMBL52076 Bioactive 7-Aminopyrido[4,3-d]pyrimidine 7f
CFAMM00235535 CHEMBL162821 Bioactive PD158780 Analog 9b
CFAMM00235471 CHEMBL166093 Bioactive PD158780 Analog 5f
CFAMM00235443 CHEMBL508481 Bioactive AGN-PC-078X0Q
CFAMM00235402 CHEMBL250753 Bioactive SureCN14561659
CFAMM00235360 CHEMBL166307 Bioactive AGN-PC-0754WE
CFAMM00235486 CHEMBL51659 Bioactive 4-Anilinopyrido[3,4-d]pyrimidine 3
CFAMM00235389 CHEMBL53711 Bioactive Pyrido[3,4-d]pyrimidine 7g
CFAMM00235514 CHEMBL53426 Bioactive AC1NS4BU
CFAMM00235449 CHEMBL165508 Bioactive PD158780 Analog 5s
CFAMM00235394 CHEMBL349070 Bioactive PD158780 Analog 5j
CFAMM00235383 CHEMBL53831 Bioactive 4-anilinopyrimido[5,4-d]pyrimidine deriv. 5b
CFAMM00235492 CHEMBL344177 Bioactive (E)-N-[4-(3-bromoanilino)pyrido[3,4-d]pyrimidin-6-yl]-3-chloroprop-2-enamide
CFAMM00235415 CHEMBL148814 Bioactive AC1LAKQF
CFAMM00235370 CHEMBL52829 Bioactive 4-anilinopyrimido[5,4-d]pyrimidine deriv. 6d
CFAMM00235433 CHEMBL258598 Bioactive AGN-PC-076GTJ
CFAMM00235483 CHEMBL338114 Bioactive pyrido[4,3-d]pyrimidine deriv. 3z
CFAMM00235524 CHEMBL162034 Bioactive PD158780 Analog 5h
CFAMM00235374 CHEMBL127058 Bioactive pyrido[4,3-d]pyrimidine deriv. 3w
CFAMM00235388 CHEMBL126893 Bioactive pyrido[4,3-d]pyrimidine deriv. 3m
CFAMM00235498 CHEMBL572371 Bioactive AGN-PC-077DR2
CFAMM00235513 CHEMBL53428 Bioactive Pyrido[4,3-d]pyrimidine 5g
CFAMM00235358 CHEMBL53777 Bioactive AC1NS4BF
CFAMM00235476 CHEMBL272865 Bioactive AGN-PC-076GTH
CFAMM00235516 CHEMBL163369 Bioactive PD158780 Analog 5r
CFAMM00235533 CHEMBL54400 Bioactive Pyrido[4,3-d]pyrimidine 5f
CFAMM00235432 CHEMBL272187 Bioactive AGN-PC-076GT4
CFAMM00235448 CHEMBL166255 Bioactive PD158780 Analog 5l
CFAMM00235423 CHEMBL165630 Bioactive PD158780 Analog 5q
CFAMM00235482 CHEMBL126791 Bioactive pyrido[4,3-d]pyrimidine deriv. 3y
CFAMM00235441 CHEMBL162719 Bioactive PD158780 Analog 5w
CFAMM00235454 CHEMBL162981 Bioactive PD158780 Analog 5v
CFAMM00235399 CHEMBL345077 Bioactive 4-Anilinopyrido[3,4-d]pyrimidine 36
CFAMM00235469 CHEMBL351629 Bioactive PD158780 Analog 5y
CFAMM00235511 CHEMBL340484 Bioactive pyrido[4,3-d]pyrimidine deriv. 3u
CFAMM00235539 CHEMBL138691 Bioactive 4-Anilinopyrido[3,4-d]pyrimidine 21
CFAMM00235386 CHEMBL138363 Bioactive 4-Anilinopyrido[3,4-d]pyrimidine 8
CFAMM00235460 CHEMBL162142 Bioactive PD158780 Analog 5u
CFAMM00235490 CHEMBL173498 Bioactive Pyrazinoquinazoline deriv. 24
CFAMM00235393 CHEMBL127041 Bioactive pyrido[4,3-d]pyrimidine deriv. 3d
CFAMM00235368 CHEMBL165788 Bioactive PD158780 Analog 8b
CFAMM00235447 CHEMBL435993 Bioactive pyrido[4,3-d]pyrimidine deriv. 3v
CFAMM00235407 CHEMBL166358 Bioactive PD158780 Analog 5i
CFAMM00235515 CHEMBL139095 Bioactive 4-Anilinopyrido[3,4-d]pyrimidine 32
CFAMM00235531 CHEMBL501618 Bioactive (E)-1-[4-(3-bromoanilino)pyrido[3,4-d]pyrimidin-6-yl]pent-3-en-2-one
CFAMM00235453 CHEMBL127082 Bioactive pyrido[4,3-d]pyrimidine deriv. 4b
CFAMM00235414 CHEMBL411243 Bioactive AGN-PC-076GT5
CFAMM00235521 CHEMBL51854 Bioactive AC1NS4BI
CFAMM00235348 CHEMBL408397 Bioactive AGN-PC-076GVI
CFAMM00235422 CHEMBL136404 Bioactive 4-Anilinopyrido[3,4-d]pyrimidine 10
CFAMM00235437 CHEMBL270696 Bioactive AGN-PC-076GVH
CFAMM00235440 CHEMBL434827 Bioactive 4-Anilinopyrido[3,4-d]pyrimidine 27
CFAMM00235538 CHEMBL334697 Bioactive 4-Anilinopyrido[3,4-d]pyrimidine 7
CFAMM00235356 CHEMBL128467 Bioactive pyrido[4,3-d]pyrimidine deriv. 3ee
CFAMM00235459 CHEMBL147131 Bioactive AC1LAKUY
CFAMM00235474 CHEMBL53796 Bioactive Pyrido[3,2-d]pyrimidine 11g
CFAMM00235380 CHEMBL53940 Bioactive Pyrido[3,4-d]pyrimidine 13f
CFAMM00235430 CHEMBL491083 Bioactive AGN-PC-078WZY
CFAMM00235550 CHEMBL49986 Bioactive SureCN2986573
CFAMM00235406 CHEMBL162053 Bioactive PD158780 Analog 5m
CFAMM00235530 CHEMBL270501 Bioactive AGN-PC-076GTW
CFAMM00235467 CHEMBL433520 Bioactive PD158780 Analog 5k
CFAMM00235520 CHEMBL51853 Bioactive Pyrido[3,4-d]pyrimidine 7b
CFAMM00235420 CHEMBL271532 Bioactive AGN-PC-076GWH
CFAMM00235480 CHEMBL165495 Bioactive PD158780 Analog 9a
CFAMM00235397 CHEMBL51228 Bioactive AC1NS4BX
CFAMM00235413 CHEMBL300217 Bioactive Pyrido[3,2-d]pyrimidine 11b
CFAMM00235537 CHEMBL299622 Bioactive AC1NS4BC
CFAMM00235384 CHEMBL340508 Bioactive pyrido[4,3-d]pyrimidine deriv. 3x
CFAMM00235508 CHEMBL334801 Bioactive 4-Anilinopyrido[3,4-d]pyrimidine 26
CFAMM00235445 CHEMBL129824 Bioactive pyrido[4,3-d]pyrimidine deriv. 3o
CFAMM00235548 CHEMBL1645474 Bioactive AGN-PC-03H0VG
CFAMM00235378 CHEMBL165574 Bioactive PD158780 Analog 5o
CFAMM00235346 CHEMBL272634 Bioactive AGN-PC-076GUD
CFAMM00235494 CHEMBL161956 Bioactive PD158780 Analog 5e
CFAMM00235479 CHEMBL341319 Bioactive pyrido[4,3-d]pyrimidine deriv. 3e
CFAMM00235372 CHEMBL408647 Bioactive AGN-PC-076GUS
CFAMM00235435 CHEMBL162223 Bioactive PD158780 Analog 5t
CFAMM00235438 CHEMBL434828 Bioactive 4-Anilinopyrido[3,4-d]pyrimidine 16
CFAMM00235451 CHEMBL128987 Bioactive pyrido[4,3-d]pyrimidine deriv. 3q
CFAMM00235396 CHEMBL342828 Bioactive 4-Anilinopyrido[3,4-d]pyrimidine 29
CFAMM00235519 CHEMBL163188 Bioactive PD158780 Analog 9c
CFAMM00235363 DNC004134 Investigative Drug PD-158780

Statistics of CFAM Database
 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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