CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID1321
Family Name D(2) dopamine receptor and D(3) dopamine receptor Ligand Azaperone Family
No. of Seeds 7 No. of Other Members 102
Family Centroid CFAMM00235688 Functional Category Investigative Drug with Natural Product
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Ligand Azaperone Superfamily
Class Class 1153

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Delavirdine Family 1 68
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Thromboxane A2 receptor Ligand Ridogrel Family 7 83
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
DNA topoisomerase 2-beta Inhibitor Nalidixic Acid Family 2 5
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Histamine H1 receptor Ligand (s)-(+)-dimethindene Maleate Family 6 12
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Histamine H1 receptor Ligand Mizolastine Family 14 603
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Transient receptor potential cation channel subfamily V member... 15 158
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Glucose-dependent insulinotropic receptor Ligand APD668 Family 3 8
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Neuromedin-K receptor Ligand SB222200 Family 17 235
Transient receptor potential cation channel subfamily V member... 6 66
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Thromboxane A2 receptor Ligand Bibv 308 Family 14 40
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Coagulation factor X Inhibitor Otamixaban Family 9 21
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Substance-P receptor Ligand TAK-637 Family 18 63
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Histone deacetylase 1 Inhibitor Pyroxamide Family 4 13
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Amg 423 family 7 47
Setipiprant family 5 118
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
ABC294640 family 5 75
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
XL-888 family 16 85
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Class II cytokine receptor Ligand IL-10 Family 7 45
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibi... 2 3
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Aromatase Inhibitor Rogletimide Family 1 2
Thromboxane-A synthase Inhibitor CGS-22652 Family 37 95
Tubulin beta chain Inhibitor 2-(3-chloro-phenyl)-1h-[1,8]napht... 3 13
Tubulin beta chain Inhibitor 7-methyl-2-m-tolyl-1h-[1,8]naphth... 7 15
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
MO15-related protein kinase Pfmrk Inhibitor (e)-1-(4-nitro-phe... 2 9
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 4 30
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... 1 6
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... 3 4
Metabotropic glutamate receptor 5 Ligand 3-chloro-n-(6-chlorop... 2 5
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(6-methylpy... 4 3
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-amin... 2 30
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Transient receptor potential cation channel subfamily V member... 2 26
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 1-(3-... 2 29
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Arachidonate 5-lipoxygenase Inhibitor Methyl 2-(benzylamino)-1... 3 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Reverse transcriptase Inhibitor PT-102 Family 8 12
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
D(2) dopamine receptor Ligand PD-135146 Family 5 11
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Reverse transcriptase Inhibitor PT-109 Family 6 7
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Metabotropic glutamate receptor 5 Ligand 1-(3-(2-methylquinoli... 2 12
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Metabotropic glutamate receptor 5 Ligand 2-(3-bromophenyl)-7-m... 3 1
Metabotropic glutamate receptor 5 Ligand 5-(2-m-tolylethynyl)p... 7 49
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Metabotropic glutamate receptor 1 Ligand (e)-4,4-dimethyl-1-qu... 2 2
Aldose reductase Inhibitor 3-(3-benzoyl-1h-pyrrol-1-yl)propano... 3 7
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 12
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 13 1
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-cyc... 3 6
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Integrin beta-3 and Integrin alpha-V inhibitor SureCN547914 fa... 8 32
Integrin alpha-V and Integrin beta-5 inhibitor SureCN6563167 f... 2 10
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
ALK tyrosine kinase receptor ligand SureCN1600195 family 1 1
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor S-(3-pyri... 1 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Progesterone receptor and Androgen receptor ligand AGN-PC-04V9... 2 2
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Serine/threonine-protein kinase mTOR and RAC-alpha serine/thre... 3 3
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 12
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZBAK family 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Tyrosine-protein kinase JAK2 inhibitor SureCN2455673 family 1 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-075KV1 f... 4 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
Reverse transcriptase/RNaseH inhibitor AC1MHDLR family 2 1
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
C-C chemokine receptor type 5 ligand AC1LA25C family 3 6
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
Reverse transcriptase/RNaseH inhibitor Dipyridodiazepinone der... 1 8
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[6-m... 13 12
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Cellular tumor antigen p53 inhibitor CHEMBL1551403 family 1 0
Platelet-activating factor receptor ligand YM-461 family 1 11
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Metabotropic glutamate receptor 1 ligand [11C]JNJ-16567083 family 9 2
Dipeptidyl peptidase 4 inhibitor SureCN3389584 family 2 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Metabotropic glutamate receptor 1 ligand SureCN13597888 family 2 1
Coagulation factor X and Kallikrein-1 inhibitor SureCN890858 f... 5 6
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
Glucose-dependent insulinotropic receptor ligand AGN-PC-0A9QCI... 2 6
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 1
Histamine H3 receptor ligand SureCN1857507 family 1 4
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 13 3
Nicotinamide phosphoribosyltransferase inhibitor 4-[[(7-chloro... 1 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 2 2
Dihydrofolate reductase inhibitor 1-[3-(2,4-diaminoquinazolin-... 2 4
B1 bradykinin receptor ligand AGN-PC-005XAO family 3 17
Beta-secretase 1 inhibitor 3-[2-amino-6-(2-methylphenyl)quinol... 5 2
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
B1 bradykinin receptor ligand 6-(8-fluoro-4-methyl-1-oxophthal... 3 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Transient receptor potential cation channel subfamily V member... 2 7
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 12
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Translocator protein inhibitor N-(4-chlorophenyl)-N-methyl-2-(... 2 0
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(2-amino-6... 13 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 9 6
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Delta-type opioid receptor and Potassium voltage-gated channel... 2 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 5
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 1 0
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[[... 22 11
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 6 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Corticotropin-releasing factor receptor 1 ligand 4-[(1R)-1-cyc... 5 6
Corticotropin-releasing factor receptor 1 ligand 4-(1-cyclopro... 3 0
Poly [ADP-ribose] polymerase 1 inhibitor 8-[[4-fluoro-3-(4-pyr... 5 2
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-isoquinolin-1-y... 3 2
Substance-P receptor ligand Netupitant family 5 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
B1 bradykinin receptor ligand methyl 2-[4-[(1R)-1-[[3-[(2-cyan... 8 7
Acetylcholinesterase and Cholinesterase inhibitor 2-amino-6-[3... 1 4
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Microsomal triglyceride transfer protein large subunit inhibit... 13 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Beta-secretase 1 and Beta-secretase 2 inhibitor 5-[(1R)-3-amin... 8 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
D(4) dopamine receptor ligand (1Z)-1-hydroxyimino-1-(3-methylp... 1 5
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Aurora kinase A inhibitor Bisanilinopyrimidine, 6j family 2 1
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 0
ALK tyrosine kinase receptor ligand N-[6-[[4-(2-hydroxypropan-... 2 0
Transient receptor potential cation channel subfamily V member... 57 4
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 2 11
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 8 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 7 6
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 4 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 6 3
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
B1 bradykinin receptor ligand N-[4-chloro-2-[[(1R)-1-[4-[3-flu... 5 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-(6-pyrrolid... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Tyrosine-protein kinase receptor TYRO3 and Mitogen-activated p... 3 7
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 6-... 1 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
5-hydroxytryptamine receptor 2B ligand SureCN1299437 family 6 7
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Translocator protein inhibitor CHEMBL2331870 family 2 0
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Motilin receptor ligand SureCN2768052 family 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 2 0
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN14726714... 4 1
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN1298914... 3 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN3514789... 1 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Androgen receptor ligand AGN-PC-009ZOP family 3 3
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 1 2
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 1
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Prothrombin inhibitor N-[(6-amino-2-methylpyridin-3-yl)methyl]... 2 0
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Progesterone receptor ligand (8S,11R,13S,14S,16R,17S)-17-(cycl... 11 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Cathepsin K and Cathepsin L1 inhibitor 5-[3-(3,4-dihydro-1H-is... 2 0
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-[3-(4-piperidi... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(3-fluor... 10 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Thromboxane-A synthase inhibitor 7-[(2S,3R)-3-pyridin-3-yl-2-b... 1 1
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-4-methy... 2 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Substance-K receptor and Substance-P receptor ligand 3,5-dichl... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-00CD7W family 5 5
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand (E)-1... 1 2
Coagulation factor X inhibitor N-[2-[(5-chloropyridin-2-yl)sul... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cathepsin S and Cathepsin K inhibitor 2-cyano-N-[(2R)-1-phenyl... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 4
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(... 5 0
Adenosine receptor A1 and Adenosine receptor A3 ligand CHEMBL4... 2 0
Transient receptor potential cation channel subfamily V member... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN4964150 ... 3 0
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Transient receptor potential cation channel subfamily V member... 3 2
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Mitogen-activated protein kinase 14 inhibitor AGN-PC-077MAQ fa... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Cannabinoid receptor 2 ligand AGN-PC-07CRHA family 4 8
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 3
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[2-[(... 3 1
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 11
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
Reverse transcriptase/RNaseH inhibitor PETT deriv. 13 family 1 0
Histone deacetylase 1 inhibitor AGN-PC-07ZGOS family 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 6 10
Reverse transcriptase/RNaseH inhibitor 181305-52-2 family 1 0
Acetyl-CoA carboxylase 2 and Acetyl-Coenzyme A carboxylase 2 i... 1 0
5-hydroxytryptamine receptor 1A ligand CHEMBL191574 family 1 1
Cannabinoid receptor 2 ligand AGN-PC-00SRU5 family 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Metabotropic glutamate receptor 1 ligand [(3aS,6aR)-2-(6-fluor... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 0
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 inhibi... 1 2
Calpain-1 catalytic subunit inhibitor 2,6-dichloro-N-[(2S)-3,4... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 2
Stromelysin-1 and Interstitial collagenase inhibitor 1-[(2S)-1... 1 3
Histone deacetylase 1 inhibitor SureCN4538615 family 2 2
C-C chemokine receptor type 3 ligand 4-[[2-(4-chlorophenyl)eth... 2 1
Coagulation factor X and Prothrombin inhibitor SureCN6578740 f... 1 0
Prelamin-A/C and Excitatory amino acid transporter 1 inhibitor... 1 0
Glycogen synthase kinase-3 beta inhibitor SureCN13987027 family 1 0
P2X purinoceptor 7 inhibitor 1-[3-[4-chloro-3-(cycloheptylmeth... 1 0
Vesicular acetylcholine transporter and Sigma non-opioid intra... 2 0
Potassium voltage-gated channel subfamily KQT member 3 and Pot... 2 0
Sigma non-opioid intracellular receptor 1 and Alpha-1B adrener... 1 4
Pyridines and Derivatives Metabolite Rotundine A Family 1 0
Putative NP ZINC03999850 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00235641 CHEMBL337124 Bioactive (Z)-but-2-enedioic acid;2-(4-fluorophenyl)-1-[1-(pyridin-4-ylmethyl)piperidin-4-yl]ethanone;hydrate
CFAMM00235613 CHEMBL192794 Bioactive AGN-PC-0064AA
CFAMM00235646 CHEMBL140872 Bioactive 1-(4-fluorophenyl)-4-(4-pyrimidin-2-ylpiperazin-1-yl)butan-1-one
CFAMM00235729 CHEMBL1270516 Bioactive AGN-PC-087ZLH
CFAMM00235688 DNC004148 Investigative Drug Azaperone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23971 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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