CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1322
Family Name Tyrosine-protein kinase Lck Inhibitor 2-(3,4,5-trihydroxy-benzylidene)-malononitrile Family
No. of Seeds 2 No. of Other Members 6
Family Centroid CFAMM00235747 Functional Category Investigative Drug with Human Metabolite
Superfamily Tyrosine-protein kinase Lck Inhibitor 2-(3,4,5-trihydroxy-benzylidene)-malononitrile Superfamily
Class Class 2069

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Oestrogen receptor ligand Dienestrol Family 35 440
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Epidermal growth factor receptor Ligand 2-(4,5-dihydroxy-indan... 2 1
Epidermal growth factor receptor Ligand 4-(2-nitrovinyl)benzen... 3 1
Cellular tumor antigen p53 and Epidermal growth factor recepto... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor SureCN... 1 0
DNA polymerase beta and Thioredoxin glutathione reductase inhi... 1 0
Epidermal growth factor receptor ligand NSC650565 family 1 0
Phenols and Derivatives Metabolite 3,4-Dihydroxyphenylglycol O... 1 1


External ID

Functional Category

Molecule Name

CFAMM00235740 DNC008595 Investigative Drug RG-50810
CFAMM00235747 DNC004149 Investigative Drug 2-(3,4,5-Trihydroxy-benzylidene)-malononitrile

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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