CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1336
Family Name Serine/threonine-protein kinase Chk2 Inhibitor 5-nitro-2-(4-phenoxy-phenyl)-1h-benzoimidazole Family
No. of Seeds 6 No. of Other Members 3
Family Centroid CFAMM00236004 Functional Category Investigative Drug
Superfamily Kappa-type opioid receptor and Delta-type opioid receptor Binder Superfamily
Class Class 1456

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Tyrosine kinase Inhibitor PKI166 Family 17 198
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimetho... 8 15
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Melanin-concentrating hormone receptor 1 Ligand ADS-103214 Family 3 4
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Mu-type opioid receptor and Nitric oxide synthase, brain ligan... 3 0
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 2 3
Neuropeptide Y receptor type 5 ligand 6-ethylsulfonyl-2-(4-phe... 4 4
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Metabotropic glutamate receptor 2 ligand 2-[[(1R,5S)-6-[(2,5-d... 2 3
Cannabinoid receptor 2 ligand SureCN14457828 family 1 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[2-(1H-benzimidaz... 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00236000 CHEMBL65693 Bioactive SureCN7452878
CFAMM00236006 CHEMBL65314 Bioactive N-[2-[(4-phenoxyphenyl)methyl]-3H-benzimidazol-5-yl]ethanesulfonamide
CFAMM00235999 DNC004680 Investigative Drug 2-(4-Phenoxy-phenyl)-1H-benzoimidazol-5-ylamine
CFAMM00236004 DNC004681 Investigative Drug 5-Nitro-2-(4-phenoxy-phenyl)-1H-benzoimidazole
CFAMM00236002 DNC004172 Investigative Drug 2-(4-Phenoxy-benzyl)-3H-benzoimidazol-5-ylamine
CFAMM00236007 DNC004197 Investigative Drug 6-Nitro-2-(4-phenoxy-benzyl)-1H-benzoimidazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27036 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543