CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1337
Family Name Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ionotropic, NMDA 1 Ligand 2-(4-phenoxy-benzyl)-3h-benzoimidazol-5-ol Family
No. of Seeds 3 No. of Other Members 23
Family Centroid CFAMM00236009 Functional Category Investigative Drug
Superfamily Oestrogen receptor and Estrogen receptor beta Binder Superfamily 3
Class Class 931

Cousin Family NamesSeedsMembers
Potassium-transporting ATPase alpha chain 1 Inhibitor Rabepraz... 4 113
Histamine H1 receptor Ligand Astemizole Family 7 240
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Tyrosine kinase Inhibitor PKI166 Family 17 198
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimetho... 8 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Serine/threonine-protein kinase Chk2 Inhibitor 5-nitro-2-(4-ph... 6 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phen... 2 9
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Melanin-concentrating hormone receptor 1 Ligand ADS-103214 Family 3 4
Platelet-derived growth factor receptor beta and Ephrin type-B... 9 16
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[5-chloro-2-[(6-m... 1 7
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Neuropeptide Y receptor type 5 and Alpha-1A adrenergic recepto... 8 2
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
Transient receptor potential M8 protein ligand (3E)-3-[5-[2-(t... 4 2
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 16 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Estrogen receptor beta and Estrogen receptor ligand SureCN6442... 1 2
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Glutamate receptor ionotropic, NMDA 2B ligand 2-[[4-(4-chlorop... 4 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 4
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Angiopoietin-1 receptor and Vascular endothelial growth factor... 2 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 1 0
Collagenase 3 inhibitor 5-[4-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Sterol O-acyltransferase 1 inhibitor 1-[4-[2-(4,5-diphenyl-1H-... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 5
Interstitial collagenase and Matrilysin inhibitor (2R)-N'-hydr... 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
5-hydroxytryptamine receptor 1A and Gonadotropin-releasing hor... 3 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-04UH85 family 2 3
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Prostaglandin E synthase inhibitor 2-[6-(2-cyclopropylethoxy)-... 6 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Cytochrome P450 2C19 and Cytochrome P450 1A2 inhibitor 2-hepty... 4 4
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[2-(1H-benzimidaz... 3 2
Arachidonate 5-lipoxygenase inhibitor 2-[(4-chlorophenyl)methy... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00236008 DNC004180 Investigative Drug 2-(4-Phenoxy-benzyl)-3H-benzoimidazol-4-ol
CFAMM00236011 DNC004174 Investigative Drug 6-Methoxy-2-(4-phenoxy-benzyl)-1H-benzoimidazole
CFAMM00236009 DNC004183 Investigative Drug 2-(4-Phenoxy-benzyl)-3H-benzoimidazol-5-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27036 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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