CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1338
Family Name cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3-dihydro-imidazo[4,5-b]quinolin-2-one Family
No. of Seeds 7 No. of Other Members 2
Family Centroid CFAMM00236041 Functional Category Investigative Drug
Superfamily cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Histamine H3 receptor Binder Superfamily
Class Class 903

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Transient receptor potential cation channel subfamily V member... 15 457
Transient receptor potential cation channel subfamily V member... 6 66
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-amin... 2 30
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 9
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00236037 DNC004175 Investigative Drug 7-Fluoro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
CFAMM00236043 DNC007138 Investigative Drug 5,7-diphenyl-3H-imidazo[4,5-b]pyridin-2-ol
CFAMM00236042 DNC004195 Investigative Drug 7-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
CFAMM00236035 DNC004188 Investigative Drug 8-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
CFAMM00236041 DNC004194 Investigative Drug 1,3-Dihydro-imidazo[4,5-b]quinolin-2-one
CFAMM00236040 DNC004193 Investigative Drug BMY-20844
CFAMM00236039 DNC004192 Investigative Drug 5-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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