CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1339
Family Name Substance-P receptor Ligand L-733060 Family
No. of Seeds 19 No. of Other Members 71
Family Centroid CFAMM00236053 Functional Category Investigative Drug
Superfamily Substance-P receptor Ligand Aprepitant Superfamily
Class Class 244

Cousin Family NamesSeedsMembers
Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96
Histamine H1 receptor Ligand Clemastine Family 5 76
Substance-P receptor Ligand Aprepitant Family 4 8
Histamine H1 receptor Ligand Diphenhydramine Family 5 75
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Muscarinic acetylcholine receptor Ligand Umeclidinium Family 7 50
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
Substance-P receptor Ligand SCH-388714 Family 26 8
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 5 14
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
Sodium-dependent dopamine transporter and Sodium-dependent nor... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 4 19
Substance-P receptor ligand (1S,2R)-2-[(1R)-1-[3,5-bis(trifluo... 12 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Sigma non-opioid intracellular receptor 1 ligand (1R)-1'-benzy... 7 27
Substance-P receptor ligand (2S)-3-[[3,5-bis(trifluoromethyl)p... 1 4
Cytochrome P450 3A4 and Beta-secretase 1 inhibitor N-[(2S,3R)-... 2 40
Substance-P receptor ligand N-[(3S,6S)-6-[[(1R)-1-[3,5-bis(tri... 1 0
Substance-P receptor ligand 1-[4-[[3,5-bis(trifluoromethyl)phe... 5 8
Substance-P receptor ligand SureCN8112982 family 1 0
Substance-P receptor ligand 4-[[3,5-bis(trifluoromethyl)phenyl... 2 1
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
Sigma non-opioid intracellular receptor 1 ligand N-benzyl-2-[(... 1 5
Muscarinic acetylcholine receptor M3 ligand 3-[8-methyl-8-(2-p... 3 0
Substance-P receptor and Potassium voltage-gated channel subfa... 10 0
Substance-P receptor ligand 1-[[(1R,2R,3S)-3-[[3,5-bis(trifluo... 4 3
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Substance-P receptor ligand 1-[(1R,2S,3S)-3-[[3,5-bis(trifluor... 7 2
Substance-P receptor ligand AGN-PC-03NGZP family 3 0
Substance-P receptor ligand 2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(... 5 0
Substance-P receptor ligand 1-[3-[[(1R)-1-[3,5-bis(trifluorome... 2 0
Substance-P receptor and Neuromedin-K receptor ligand 3-[[(1R)... 1 2
Substance-P receptor ligand 2-[[(1R,2S,3S)-3-[[3,5-bis(trifluo... 6 0
Substance-P receptor ligand (5R)-5-[[[(1R,2S,3S)-3-[(1R)-1-[3,... 6 0
Substance-P receptor ligand (1R,2S,3S)-3-[(1R)-1-[3,5-bis(trif... 8 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 5 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 1
Sodium-dependent serotonin transporter and Substance-P recepto... 2 2
Substance-P receptor and Sodium-dependent serotonin transporte... 6 1
Substance-P receptor ligand 1-[(3S,4R)-3-[(1R)-1-[3,5-bis(trif... 9 0
Substance-P receptor ligand (5S)-5-[(3S,4R)-3-[(1R)-1-[3,5-bis... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Substance-P receptor ligand SureCN8415737 family 3 4
Substance-P receptor ligand methyl 2-[(2S,3S)-2-[[3,5-bis(trif... 1 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 3
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Substance-P receptor ligand AGN-PC-02K8GG family 1 1
Sodium-dependent dopamine transporter and Sigma non-opioid int... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Substance-P receptor and Potassium voltage-gated channel subfa... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Substance-P receptor ligand SureCN8912140 family 2 12
Substance-P receptor ligand N-[(3S,5S)-5-[[(1R)-1-[3,5-bis(tri... 10 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0793IB... 2 0
Substance-P receptor and Voltage-dependent L-type calcium chan... 1 0
Cathepsin D and Beta-secretase 1 inhibitor benzyl 3-[[(2R,3S)-... 1 0
Phenylalanine--tRNA ligase alpha subunit inhibitor TCMDC-14030... 1 1
Putative NP ZINC04026324 Family 6 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00236046 CHEMBL85047 Bioactive (2R,3R)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidine
CFAMM00236060 CHEMBL1270066 Bioactive N-[(3S,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]acetamide
CFAMM00236125 CHEMBL1270174 Bioactive N-[(3S,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]propanamide
CFAMM00236098 CHEMBL102032 Bioactive (2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-phenylpiperidine
CFAMM00236091 CHEMBL92701 Bioactive (2R)-2-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-2-phenylpiperidine
CFAMM00236130 CHEMBL63793 Bioactive 2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]-N,N-dimethylacetamide
CFAMM00236084 CHEMBL50270 Bioactive (2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenyl-1-azabicyclo[2.2.2]octane
CFAMM00236051 CHEMBL329105 Bioactive 2-[[(1S)-2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenylethyl]amino]acetamide
CFAMM00236103 CHEMBL63240 Bioactive 2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]-N-methylacetamide
CFAMM00236076 CHEMBL67612 Bioactive methyl 2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]acetate
CFAMM00236128 CHEMBL1270970 Bioactive (2S)-2-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-2-phenylpiperidine
CFAMM00236108 CHEMBL63762 Bioactive 4-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]butanamide
CFAMM00236088 CHEMBL67667 Bioactive 3-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]propanamide
CFAMM00236068 CHEMBL332284 Bioactive Piperidine, 2-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]-2-phenyl-
CFAMM00236061 CHEMBL1270067 Bioactive N-[(3R,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]acetamide
CFAMM00236074 CHEMBL1256740 Bioactive NCGC00094093-01
CFAMM00236053 DNC004178 Investigative Drug L-733060
CFAMM00236056 DNC004190 Investigative Drug L-736281

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48680 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543