Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.
Cousin Family Names Seeds Members Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96 Histamine H1 receptor Ligand Clemastine Family 5 76 Substance-P receptor Ligand Aprepitant Family 4 8 Histamine H1 receptor Ligand Diphenhydramine Family 5 75 Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152 Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224 Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20 Muscarinic acetylcholine receptor Ligand Umeclidinium Family 7 50 Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13 Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110 Substance-P receptor Ligand SCH-388714 Family 26 8 Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1 Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3 Potassium voltage-gated channel subfamily H member 2 and Sodiu... 5 14 Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7 Sodium-dependent dopamine transporter and Sodium-dependent nor... 5 2 Sodium-dependent dopamine transporter and Sodium-dependent nor... 4 19 Substance-P receptor ligand (1S,2R)-2-[(1R)-1-[3,5-bis(trifluo... 12 0 Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0 Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5 Sigma non-opioid intracellular receptor 1 ligand (1R)-1'-benzy... 7 27 Substance-P receptor ligand (2S)-3-[[3,5-bis(trifluoromethyl)p... 1 4 Cytochrome P450 3A4 and Beta-secretase 1 inhibitor N-[(2S,3R)-... 2 40 Substance-P receptor ligand N-[(3S,6S)-6-[[(1R)-1-[3,5-bis(tri... 1 0 Substance-P receptor ligand 1-[4-[[3,5-bis(trifluoromethyl)phe... 5 8 Substance-P receptor ligand SureCN8112982 family 1 0 Substance-P receptor ligand 4-[[3,5-bis(trifluoromethyl)phenyl... 2 1 Substance-P receptor ligand AGN-PC-02K8FR family 1 3 Sigma non-opioid intracellular receptor 1 ligand N-benzyl-2-[(... 1 5 Muscarinic acetylcholine receptor M3 ligand 3-[8-methyl-8-(2-p... 3 0 Substance-P receptor and Potassium voltage-gated channel subfa... 10 0 Substance-P receptor ligand 1-[[(1R,2R,3S)-3-[[3,5-bis(trifluo... 4 3 Sodium-dependent dopamine transporter and Transporter inhibito... 2 0 Substance-P receptor ligand 1-[(1R,2S,3S)-3-[[3,5-bis(trifluor... 7 2 Substance-P receptor ligand AGN-PC-03NGZP family 3 0 Substance-P receptor ligand 2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(... 5 0 Substance-P receptor ligand 1-[3-[[(1R)-1-[3,5-bis(trifluorome... 2 0 Substance-P receptor and Neuromedin-K receptor ligand 3-[[(1R)... 1 2 Substance-P receptor ligand 2-[[(1R,2S,3S)-3-[[3,5-bis(trifluo... 6 0 Substance-P receptor ligand (5R)-5-[[[(1R,2S,3S)-3-[(1R)-1-[3,... 6 0 Substance-P receptor ligand (1R,2S,3S)-3-[(1R)-1-[3,5-bis(trif... 8 0 Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 5 1 Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 1 Sodium-dependent serotonin transporter and Substance-P recepto... 2 2 Substance-P receptor and Sodium-dependent serotonin transporte... 6 1 Substance-P receptor ligand 1-[(3S,4R)-3-[(1R)-1-[3,5-bis(trif... 9 0 Substance-P receptor ligand (5S)-5-[(3S,4R)-3-[(1R)-1-[3,5-bis... 3 0 Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0 Substance-P receptor ligand SureCN8415737 family 3 4 Substance-P receptor ligand methyl 2-[(2S,3S)-2-[[3,5-bis(trif... 1 1 Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 0 Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 3 Sodium-dependent dopamine transporter and Transporter inhibito... 2 0 Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6 Substance-P receptor ligand AGN-PC-02K8GG family 1 1 Sodium-dependent dopamine transporter and Sigma non-opioid int... 2 0 Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0 Substance-P receptor and Potassium voltage-gated channel subfa... 2 0 Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0 Substance-P receptor ligand SureCN8912140 family 2 12 Substance-P receptor ligand N-[(3S,5S)-5-[[(1R)-1-[3,5-bis(tri... 10 0 Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0793IB... 2 0 Substance-P receptor and Voltage-dependent L-type calcium chan... 1 0 Cathepsin D and Beta-secretase 1 inhibitor benzyl 3-[[(2R,3S)-... 1 0 Phenylalanine--tRNA ligase alpha subunit inhibitor TCMDC-14030... 1 1 Putative NP ZINC04026324 Family 6 1
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00236046
CHEMBL85047
Bioactive
(2R,3R)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidine CFAMM00236060
CHEMBL1270066
Bioactive
N-[(3S,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]acetamide CFAMM00236125
CHEMBL1270174
Bioactive
N-[(3S,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]propanamide CFAMM00236098
CHEMBL102032
Bioactive
(2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-phenylpiperidine CFAMM00236091
CHEMBL92701
Bioactive
(2R)-2-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-2-phenylpiperidine CFAMM00236130
CHEMBL63793
Bioactive
2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]-N,N-dimethylacetamide CFAMM00236084
CHEMBL50270
Bioactive
(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenyl-1-azabicyclo[2.2.2]octane CFAMM00236051
CHEMBL329105
Bioactive
2-[[(1S)-2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenylethyl]amino]acetamide CFAMM00236103
CHEMBL63240
Bioactive
2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]-N-methylacetamide CFAMM00236076
CHEMBL67612
Bioactive
methyl 2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]acetate CFAMM00236128
CHEMBL1270970
Bioactive
(2S)-2-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-2-phenylpiperidine CFAMM00236108
CHEMBL63762
Bioactive
4-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]butanamide CFAMM00236088
CHEMBL67667
Bioactive
3-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]propanamide CFAMM00236068
CHEMBL332284
Bioactive
Piperidine, 2-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]-2-phenyl- CFAMM00236061
CHEMBL1270067
Bioactive
N-[(3R,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]acetamide CFAMM00236074
CHEMBL1256740
Bioactive
NCGC00094093-01 CFAMM00236053
DNC004178
Investigative Drug
L-733060 CFAMM00236056
DNC004190
Investigative Drug
L-736281
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00236067
CHEMBL213906
Bioactive
N-benzyl-3-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-3-phenylcyclobutan-1-amine CFAMM00236080
CHEMBL145265
Bioactive
AGN-PC-00GFDP CFAMM00236126
CHEMBL1270175
Bioactive
N-[(3S,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]cyclopropanecarboxamide CFAMM00236093
CHEMBL142477
Bioactive
AGN-PC-023Q0Q CFAMM00236106
CHEMBL384157
Bioactive
2-[[(1R,2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylcyclopentyl]-methylamino]acetamide CFAMM00236119
CHEMBL56038
Bioactive
2-[[(2S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1,1-diphenylpropan-2-yl]amino]acetamide CFAMM00236112
CHEMBL452534
Bioactive
1-[(3S,5S)-5-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-2-oxo-5-phenylpyrrolidin-3-yl]piperidin-2-one CFAMM00236092
CHEMBL379289
Bioactive
2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)cyclopentyl]-ethylamino]acetamide CFAMM00236105
CHEMBL323128
Bioactive
2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenylpropan-1-amine CFAMM00236118
CHEMBL508661
Bioactive
1-[(3R,5S)-5-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-2-oxo-5-phenylpyrrolidin-3-yl]piperidin-2-one CFAMM00236052
CHEMBL1270371
Bioactive
N-[(3S,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]methanesulfonamide CFAMM00236065
CHEMBL48680
Bioactive
2-[(2S,3S)-2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-3-phenylmorpholin-4-yl]acetamide CFAMM00236117
CHEMBL22194
Bioactive
L-709210 CFAMM00236110
CHEMBL145535
Bioactive
2-benzhydryl-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-azabicyclo[2.2.2]octane CFAMM00236123
CHEMBL49638
Bioactive
(2R,3S)-2-benzhydryl-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-azabicyclo[2.2.2]octane CFAMM00236090
CHEMBL333882
Bioactive
N-benzyl-2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]-N-methylacetamide CFAMM00236070
CHEMBL378689
Bioactive
2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)cyclopentyl]-methylamino]-N-(2-methoxyethyl)acetamide CFAMM00236050
CHEMBL379707
Bioactive
2-[[(1S,2R,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylcyclopentyl]-methylamino]acetamide CFAMM00236122
CHEMBL1270271
Bioactive
1-[(3S,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]pyrrolidin-2-one CFAMM00236063
CHEMBL327765
Bioactive
2-[[(1S)-2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenylethyl]-methylamino]acetamide CFAMM00236102
CHEMBL216018
Bioactive
2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)cyclopentyl]-methylamino]-1-morpholin-4-ylethanone CFAMM00236069
CHEMBL28055
Bioactive
AGN-PC-03VRAJ CFAMM00236048
CHEMBL213538
Bioactive
2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)cyclopentyl]-(2-methoxyethyl)amino]acetamide CFAMM00236114
CHEMBL215373
Bioactive
2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)cyclopentyl]-methylamino]acetamide CFAMM00236120
CHEMBL93243
Bioactive
AGN-PC-074PWG CFAMM00236100
CHEMBL212991
Bioactive
(1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)-N-(2-methoxyethyl)cyclopentan-1-amine CFAMM00236113
CHEMBL422931
Bioactive
4-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine CFAMM00236079
CHEMBL20362
Bioactive
[(3S,4S)-4-(2-benzhydryloxyethyl)-1-[(4-fluorophenyl)methyl]piperidin-3-yl] propanoate CFAMM00236059
CHEMBL1209105
Bioactive
N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(oxolan-2-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide CFAMM00236058
CHEMBL122859
Bioactive
1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-phenylethyl)piperazin-2-one CFAMM00236071
CHEMBL297068
Bioactive
(2R,3R)-2-benzhydryl-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-azabicyclo[2.2.2]octane CFAMM00236097
CHEMBL296228
Bioactive
(2S,3R)-2-benzhydryl-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-azabicyclo[2.2.2]octane CFAMM00236082
CHEMBL1209357
Bioactive
N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(2-methyloxolan-2-yl)phenyl]cyclopropyl]amino]butan-2-yl]acetamide CFAMM00236095
CHEMBL2347693
Bioactive
(3R)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-3-phenylazepane CFAMM00236107
CHEMBL1163697
Bioactive
AGN-PC-07YQ1F CFAMM00236081
CHEMBL1209356
Bioactive
N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(oxolan-2-yl)phenyl]cyclopropyl]amino]butan-2-yl]acetamide CFAMM00236132
CHEMBL379744
Bioactive
2-[[(1S,2R,3R)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylcyclopentyl]amino]acetamide CFAMM00236099
CHEMBL466145
Bioactive
(2S)-1-[4-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperazin-1-yl]-3-phenylpropan-2-amine CFAMM00236045
CHEMBL334072
Bioactive
(2S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1,1-diphenylpropan-2-amine CFAMM00236085
CHEMBL2347692
Bioactive
(3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-3-phenylazepane CFAMM00236124
CHEMBL281940
Bioactive
AGN-PC-025W5L CFAMM00236078
CHEMBL92818
Bioactive
(1S)-2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenylethanamine CFAMM00236044
CHEMBL63278
Bioactive
1-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]ethanone CFAMM00236064
CHEMBL93216
Bioactive
(2R)-2-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-2-phenylpyrrolidine CFAMM00236077
CHEMBL416194
Bioactive
2-[4-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperazin-1-yl]-2-phenylethanol CFAMM00236129
CHEMBL466936
Bioactive
(2R)-1-[4-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperazin-1-yl]-3-phenylpropan-2-amine CFAMM00236083
CHEMBL302315
Bioactive
methyl 2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]-2-oxoacetate CFAMM00236109
CHEMBL63257
Bioactive
2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]-2-oxoacetamide CFAMM00236089
CHEMBL51477
Bioactive
2-[(2S,3S)-2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-3-phenylmorpholin-4-yl]acetic acid CFAMM00236115
CHEMBL92524
Bioactive
AGN-PC-074PUZ CFAMM00236062
CHEMBL377712
Bioactive
(4R)-4-[[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-4-phenylimidazolidin-2-one CFAMM00236121
CHEMBL281828
Bioactive
SureCN8105654 CFAMM00236101
CHEMBL292496
Bioactive
2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]acetic acid CFAMM00236055
CHEMBL442028
Bioactive
AGN-PC-02TAEZ CFAMM00236127
CHEMBL204918
Bioactive
(4S)-4-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-4-(4-fluorophenyl)imidazolidin-2-one CFAMM00236094
CHEMBL143377
Bioactive
SureCN8114987 CFAMM00236133
CHEMBL203655
Bioactive
(4S)-4-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-4-phenylimidazolidin-2-one CFAMM00236047
CHEMBL120546
Bioactive
3-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-3-phenylpiperidine CFAMM00236054
57033412
Patent Compound
CFAMM00236086
53888264
Patent Compound
CFAMM00236073
20345274
Patent Compound
SureCN11461738 CFAMM00236066
22870581
Patent Compound
SureCN5224481 CFAMM00236131
18922404
Patent Compound
AGN-PC-0229EY CFAMM00236072
53893197
Patent Compound
SureCN7066526 CFAMM00236111
18665969
Patent Compound
CFAMM00236104
19049335
Patent Compound
SureCN8910627 CFAMM00236116
22859252
Patent Compound
CFAMM00236057
57154908
Patent Compound
AGN-PC-0BOH63 CFAMM00236096
18922345
Patent Compound
AGN-PC-0229E2 CFAMM00236075
57241605
Patent Compound
AGN-PC-0BQ5ZW CFAMM00236087
54524404
Patent Compound
Statistics of CFAM Database
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
48680 visits since 2014 .........
Dr.
Chen Yuzong
Deputy
Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore
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