Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96 Histamine H1 receptor Ligand Clemastine Family 5 76 Substance-P receptor Ligand Aprepitant Family 4 8 Histamine H1 receptor Ligand Diphenhydramine Family 5 75 Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152 Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224 Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20 Muscarinic acetylcholine receptor Ligand Umeclidinium Family 7 50 Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13 Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110 Substance-P receptor Ligand SCH-388714 Family 26 8 Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1 Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3 Potassium voltage-gated channel subfamily H member 2 and Sodiu... 5 14 Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7 Sodium-dependent dopamine transporter and Sodium-dependent nor... 5 2 Sodium-dependent dopamine transporter and Sodium-dependent nor... 4 19 Substance-P receptor ligand (1S,2R)-2-[(1R)-1-[3,5-bis(trifluo... 12 0 Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0 Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5 Sigma non-opioid intracellular receptor 1 ligand (1R)-1'-benzy... 7 27 Substance-P receptor ligand (2S)-3-[[3,5-bis(trifluoromethyl)p... 1 4 Cytochrome P450 3A4 and Beta-secretase 1 inhibitor N-[(2S,3R)-... 2 40 Substance-P receptor ligand N-[(3S,6S)-6-[[(1R)-1-[3,5-bis(tri... 1 0 Substance-P receptor ligand 1-[4-[[3,5-bis(trifluoromethyl)phe... 5 8 Substance-P receptor ligand SureCN8112982 family 1 0 Substance-P receptor ligand 4-[[3,5-bis(trifluoromethyl)phenyl... 2 1 Substance-P receptor ligand AGN-PC-02K8FR family 1 3 Sigma non-opioid intracellular receptor 1 ligand N-benzyl-2-[(... 1 5 Muscarinic acetylcholine receptor M3 ligand 3-[8-methyl-8-(2-p... 3 0 Substance-P receptor and Potassium voltage-gated channel subfa... 10 0 Substance-P receptor ligand 1-[[(1R,2R,3S)-3-[[3,5-bis(trifluo... 4 3 Sodium-dependent dopamine transporter and Transporter inhibito... 2 0 Substance-P receptor ligand 1-[(1R,2S,3S)-3-[[3,5-bis(trifluor... 7 2 Substance-P receptor ligand AGN-PC-03NGZP family 3 0 Substance-P receptor ligand 2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(... 5 0 Substance-P receptor ligand 1-[3-[[(1R)-1-[3,5-bis(trifluorome... 2 0 Substance-P receptor and Neuromedin-K receptor ligand 3-[[(1R)... 1 2 Substance-P receptor ligand 2-[[(1R,2S,3S)-3-[[3,5-bis(trifluo... 6 0 Substance-P receptor ligand (5R)-5-[[[(1R,2S,3S)-3-[(1R)-1-[3,... 6 0 Substance-P receptor ligand (1R,2S,3S)-3-[(1R)-1-[3,5-bis(trif... 8 0 Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 5 1 Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 1 Sodium-dependent serotonin transporter and Substance-P recepto... 2 2 Substance-P receptor and Sodium-dependent serotonin transporte... 6 1 Substance-P receptor ligand 1-[(3S,4R)-3-[(1R)-1-[3,5-bis(trif... 9 0 Substance-P receptor ligand (5S)-5-[(3S,4R)-3-[(1R)-1-[3,5-bis... 3 0 Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0 Substance-P receptor ligand SureCN8415737 family 3 4 Substance-P receptor ligand methyl 2-[(2S,3S)-2-[[3,5-bis(trif... 1 1 Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 0 Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 3 Sodium-dependent dopamine transporter and Transporter inhibito... 2 0 Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6 Substance-P receptor ligand AGN-PC-02K8GG family 1 1 Sodium-dependent dopamine transporter and Sigma non-opioid int... 2 0 Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0 Substance-P receptor and Potassium voltage-gated channel subfa... 2 0 Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0 Substance-P receptor ligand SureCN8912140 family 2 12 Substance-P receptor ligand N-[(3S,5S)-5-[[(1R)-1-[3,5-bis(tri... 10 0 Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0793IB... 2 0 Substance-P receptor and Voltage-dependent L-type calcium chan... 1 0 Cathepsin D and Beta-secretase 1 inhibitor benzyl 3-[[(2R,3S)-... 1 0 Phenylalanine--tRNA ligase alpha subunit inhibitor TCMDC-14030... 1 1 Putative NP ZINC04026324 Family 6 1
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00236068 CHEMBL332284 Bioactive
Piperidine, 2-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]-2-phenyl- CFAMM00236061 CHEMBL1270067 Bioactive
N-[(3R,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]acetamide CFAMM00236074 CHEMBL1256740 Bioactive
NCGC00094093-01 CFAMM00236046 CHEMBL85047 Bioactive
(2R,3R)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidine CFAMM00236060 CHEMBL1270066 Bioactive
N-[(3S,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]acetamide CFAMM00236125 CHEMBL1270174 Bioactive
N-[(3S,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]propanamide CFAMM00236098 CHEMBL102032 Bioactive
(2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-phenylpiperidine CFAMM00236091 CHEMBL92701 Bioactive
(2R)-2-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-2-phenylpiperidine CFAMM00236130 CHEMBL63793 Bioactive
2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]-N,N-dimethylacetamide CFAMM00236084 CHEMBL50270 Bioactive
(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenyl-1-azabicyclo[2.2.2]octane CFAMM00236051 CHEMBL329105 Bioactive
2-[[(1S)-2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenylethyl]amino]acetamide CFAMM00236103 CHEMBL63240 Bioactive
2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]-N-methylacetamide CFAMM00236076 CHEMBL67612 Bioactive
methyl 2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]acetate CFAMM00236128 CHEMBL1270970 Bioactive
(2S)-2-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-2-phenylpiperidine CFAMM00236108 CHEMBL63762 Bioactive
4-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]butanamide CFAMM00236088 CHEMBL67667 Bioactive
3-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]propanamide CFAMM00236053 DNC004178 Investigative Drug
L-733060 CFAMM00236056 DNC004190 Investigative Drug
L-736281
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00236114 CHEMBL215373 Bioactive
2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)cyclopentyl]-methylamino]acetamide CFAMM00236120 CHEMBL93243 Bioactive
AGN-PC-074PWG CFAMM00236100 CHEMBL212991 Bioactive
(1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)-N-(2-methoxyethyl)cyclopentan-1-amine CFAMM00236113 CHEMBL422931 Bioactive
4-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine CFAMM00236067 CHEMBL213906 Bioactive
N-benzyl-3-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-3-phenylcyclobutan-1-amine CFAMM00236080 CHEMBL145265 Bioactive
AGN-PC-00GFDP CFAMM00236126 CHEMBL1270175 Bioactive
N-[(3S,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]cyclopropanecarboxamide CFAMM00236093 CHEMBL142477 Bioactive
AGN-PC-023Q0Q CFAMM00236106 CHEMBL384157 Bioactive
2-[[(1R,2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylcyclopentyl]-methylamino]acetamide CFAMM00236119 CHEMBL56038 Bioactive
2-[[(2S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1,1-diphenylpropan-2-yl]amino]acetamide CFAMM00236112 CHEMBL452534 Bioactive
1-[(3S,5S)-5-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-2-oxo-5-phenylpyrrolidin-3-yl]piperidin-2-one CFAMM00236092 CHEMBL379289 Bioactive
2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)cyclopentyl]-ethylamino]acetamide CFAMM00236105 CHEMBL323128 Bioactive
2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenylpropan-1-amine CFAMM00236118 CHEMBL508661 Bioactive
1-[(3R,5S)-5-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-2-oxo-5-phenylpyrrolidin-3-yl]piperidin-2-one CFAMM00236052 CHEMBL1270371 Bioactive
N-[(3S,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]methanesulfonamide CFAMM00236065 CHEMBL48680 Bioactive
2-[(2S,3S)-2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-3-phenylmorpholin-4-yl]acetamide CFAMM00236117 CHEMBL22194 Bioactive
L-709210 CFAMM00236110 CHEMBL145535 Bioactive
2-benzhydryl-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-azabicyclo[2.2.2]octane CFAMM00236123 CHEMBL49638 Bioactive
(2R,3S)-2-benzhydryl-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-azabicyclo[2.2.2]octane CFAMM00236090 CHEMBL333882 Bioactive
N-benzyl-2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]-N-methylacetamide CFAMM00236070 CHEMBL378689 Bioactive
2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)cyclopentyl]-methylamino]-N-(2-methoxyethyl)acetamide CFAMM00236050 CHEMBL379707 Bioactive
2-[[(1S,2R,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylcyclopentyl]-methylamino]acetamide CFAMM00236122 CHEMBL1270271 Bioactive
1-[(3S,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]pyrrolidin-2-one CFAMM00236063 CHEMBL327765 Bioactive
2-[[(1S)-2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenylethyl]-methylamino]acetamide CFAMM00236102 CHEMBL216018 Bioactive
2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)cyclopentyl]-methylamino]-1-morpholin-4-ylethanone CFAMM00236069 CHEMBL28055 Bioactive
AGN-PC-03VRAJ CFAMM00236048 CHEMBL213538 Bioactive
2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)cyclopentyl]-(2-methoxyethyl)amino]acetamide CFAMM00236081 CHEMBL1209356 Bioactive
N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(oxolan-2-yl)phenyl]cyclopropyl]amino]butan-2-yl]acetamide CFAMM00236107 CHEMBL1163697 Bioactive
AGN-PC-07YQ1F CFAMM00236079 CHEMBL20362 Bioactive
[(3S,4S)-4-(2-benzhydryloxyethyl)-1-[(4-fluorophenyl)methyl]piperidin-3-yl] propanoate CFAMM00236059 CHEMBL1209105 Bioactive
N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(oxolan-2-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide CFAMM00236058 CHEMBL122859 Bioactive
1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-phenylethyl)piperazin-2-one CFAMM00236071 CHEMBL297068 Bioactive
(2R,3R)-2-benzhydryl-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-azabicyclo[2.2.2]octane CFAMM00236097 CHEMBL296228 Bioactive
(2S,3R)-2-benzhydryl-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-azabicyclo[2.2.2]octane CFAMM00236082 CHEMBL1209357 Bioactive
N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(2-methyloxolan-2-yl)phenyl]cyclopropyl]amino]butan-2-yl]acetamide CFAMM00236095 CHEMBL2347693 Bioactive
(3R)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-3-phenylazepane CFAMM00236101 CHEMBL292496 Bioactive
2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]acetic acid CFAMM00236127 CHEMBL204918 Bioactive
(4S)-4-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-4-(4-fluorophenyl)imidazolidin-2-one CFAMM00236055 CHEMBL442028 Bioactive
AGN-PC-02TAEZ CFAMM00236094 CHEMBL143377 Bioactive
SureCN8114987 CFAMM00236047 CHEMBL120546 Bioactive
3-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-3-phenylpiperidine CFAMM00236133 CHEMBL203655 Bioactive
(4S)-4-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-4-phenylimidazolidin-2-one CFAMM00236132 CHEMBL379744 Bioactive
2-[[(1S,2R,3R)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylcyclopentyl]amino]acetamide CFAMM00236099 CHEMBL466145 Bioactive
(2S)-1-[4-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperazin-1-yl]-3-phenylpropan-2-amine CFAMM00236045 CHEMBL334072 Bioactive
(2S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1,1-diphenylpropan-2-amine CFAMM00236085 CHEMBL2347692 Bioactive
(3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-3-phenylazepane CFAMM00236124 CHEMBL281940 Bioactive
AGN-PC-025W5L CFAMM00236078 CHEMBL92818 Bioactive
(1S)-2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenylethanamine CFAMM00236044 CHEMBL63278 Bioactive
1-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]ethanone CFAMM00236064 CHEMBL93216 Bioactive
(2R)-2-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-2-phenylpyrrolidine CFAMM00236077 CHEMBL416194 Bioactive
2-[4-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperazin-1-yl]-2-phenylethanol CFAMM00236129 CHEMBL466936 Bioactive
(2R)-1-[4-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperazin-1-yl]-3-phenylpropan-2-amine CFAMM00236083 CHEMBL302315 Bioactive
methyl 2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]-2-oxoacetate CFAMM00236109 CHEMBL63257 Bioactive
2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]-2-oxoacetamide CFAMM00236089 CHEMBL51477 Bioactive
2-[(2S,3S)-2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-3-phenylmorpholin-4-yl]acetic acid CFAMM00236115 CHEMBL92524 Bioactive
AGN-PC-074PUZ CFAMM00236062 CHEMBL377712 Bioactive
(4R)-4-[[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-4-phenylimidazolidin-2-one CFAMM00236121 CHEMBL281828 Bioactive
SureCN8105654 CFAMM00236087 54524404 Patent Compound
CFAMM00236054 57033412 Patent Compound
CFAMM00236073 20345274 Patent Compound
SureCN11461738 CFAMM00236086 53888264 Patent Compound
CFAMM00236066 22870581 Patent Compound
SureCN5224481 CFAMM00236131 18922404 Patent Compound
AGN-PC-0229EY CFAMM00236072 53893197 Patent Compound
SureCN7066526 CFAMM00236111 18665969 Patent Compound
CFAMM00236104 19049335 Patent Compound
SureCN8910627 CFAMM00236116 22859252 Patent Compound
CFAMM00236057 57154908 Patent Compound
AGN-PC-0BOH63 CFAMM00236096 18922345 Patent Compound
AGN-PC-0229E2 CFAMM00236075 57241605 Patent Compound
AGN-PC-0BQ5ZW
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Dr.
Chen Yuzong Deputy
Director of Center for Computational Science and Engineering All rights reserved.
