CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1345
Family Name cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3,9,9a-tetrahydro-imidazo[4,5-b]quinolin-2-one Family
No. of Seeds 3 No. of Other Members 4
Family Centroid CFAMM00236161 Functional Category Investigative Drug
Superfamily Histamine H1 receptor Ligand Epinastine Superfamily
Class Class 562

Cousin Family NamesSeedsMembers
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Histamine H1 receptor Ligand Antazoline Family 5 57
D(2) dopamine receptor Ligand Nomifensine Family 6 100
5-hydroxytryptamine receptor 5A Ligand N,4-dimethyl-3,4-dihydr... 8 51
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
5-hydroxytryptamine receptor 6 Ligand [2-(3h-indol-1-yl)-ethyl... 2 7
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
Acetylcholinesterase Inhibitor (3-hydroxy-2-methyl-phenyl)-tri... 4 25
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 13
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 0
Sigma non-opioid intracellular receptor 1 and Glutamate recept... 1 0
Sigma non-opioid intracellular receptor 1 and Glutamate recept... 2 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00236158 CHEMBL37352 Bioactive AGN-PC-00OAAN
CFAMM00236162 CHEMBL38406 Bioactive AGN-PC-00NQHG
CFAMM00236161 DNC004196 Investigative Drug 1,3,9,9a-Tetrahydro-imidazo[4,5-b]quinolin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

44593 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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