CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1355
Family Name Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-methoxy-n-(3-phenyl-isoquinolin-1-yl)-benzamide Family
No. of Seeds 1 No. of Other Members 16
Family Centroid CFAMM00236377 Functional Category Investigative Drug with Natural Product
Superfamily Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-methoxy-n-(3-phenyl-isoquinolin-1-yl)-benzamide Superfamily
Class Class 2020

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Smoothened homolog Inhibitor LDE225 Family 3 76
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
P2X purinoceptor 7 Inhibitor A-740003 Family 2 6
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Tubulin beta chain Inhibitor 2-furan-2-yl-7-methyl-1h-[1,8]nap... 1 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 22
cAMP-specific 3',5'-cyclic phosphodiesterase 4C and cAMP-speci... 12 2
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Pol polyprotein inhibitor 3-[[(4R,5S,6S,7R)-4,7-dibenzyl-3-(3,... 12 1
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Alpha-1A adrenergic receptor ligand 4-[4-(4-amino-6,7-dimethox... 3 0
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Dihydrofolate reductase inhibitor 3-(2,4-diamino-6-methylquina... 2 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FSU ... 1 1
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 14 6
Microsomal triglyceride transfer protein large subunit inhibit... 9 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cholinesterase and Acetylcholinesterase inhibitor tacrine deri... 10 0
Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy... 12 6
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(4-methoxyphenyl)... 2 1
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Nuclear receptor ROR-gamma and Prelamin-A/C ligand ST50133141 ... 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Urotensin-2 receptor ligand 2-[(1R)-4-[(6-chloropyrazin-2-yl)a... 2 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 2 25
Smoothened homolog inhibitor N-[amino-[3-(1H-indol-2-yl)anilin... 1 4
Extracellular calcium-sensing receptor ligand SureCN13996883 f... 1 8


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00236377 DNC004223 Investigative Drug 4-Methoxy-N-(3-phenyl-isoquinolin-1-yl)-benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26190 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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