CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1357
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Cartazolate Family
No. of Seeds 11 No. of Other Members 105
Family Centroid CFAMM00236460 Functional Category Investigative Drug with Natural Product
Superfamily Serine/threonine-protein kinase B-raf and cGMP-specific 3',5'-cyclic phosphodiesterase Binder Superfamily
Class Class 2087

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Vascular endothelial growth factor receptor 2 ligand SureCN405... 2 8
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Mitogen-activated protein kinase 14 inhibitor methyl 4-[5-(eth... 3 11
Adenosine receptor A1 ligand ethyl 1-(2-chloro-2-phenylethyl)-... 5 1
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(4-methoxyphenyl)... 2 1
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(1-propan-2-ylpyr... 5 6
Mitogen-activated protein kinase 14 inhibitor ethyl 4-[5-[(3-f... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 13
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Histamine H3 receptor ligand SureCN7961030 family 1 2


External ID

Functional Category

Molecule Name

CFAMM00236453 CHEMBL85605 Bioactive SureCN1053441
CFAMM00236425 CHEMBL314580 Bioactive SureCN1053442
CFAMM00236429 CHEMBL315351 Bioactive prop-2-enyl 4-amino-6-methyl-1-pent-4-ynylpyrazolo[3,4-b]pyridine-5-carboxylate
CFAMM00236516 CHEMBL511488 Bioactive ethyl 4-(cyclohexylamino)-1-ethylpyrazolo[3,4-b]pyridine-5-carboxylate
CFAMM00236457 CHEMBL83571 Bioactive SureCN1059210
CFAMM00236530 CHEMBL85794 Bioactive prop-2-enyl 4-amino-1-hex-5-ynyl-6-methylpyrazolo[3,4-b]pyridine-5-carboxylate
CFAMM00236469 CHEMBL84567 Bioactive Tracazolate
CFAMM00236433 CHEMBL312907 Bioactive SureCN1059182
CFAMM00236462 CHEMBL506982 Bioactive ethyl 1-ethyl-4-(oxan-4-ylamino)pyrazolo[3,4-b]pyridine-5-carboxylate
CFAMM00236460 DNC004226 Investigative Drug Cartazolate
CFAMM00236423 DNC012425 Investigative Drug ridine-5-carboxylic acid ethyl ester

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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