CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1372
Family Name Integrin beta-3 Inhibitor L-750034 Family
No. of Seeds 7 No. of Other Members 38
Family Centroid CFAMM00236995 Functional Category Investigative Drug
Superfamily Integrin beta-3 Inhibitor L-750034 Superfamily
Class Class 617

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
ATP-sensitive inward rectifier potassium channel 10 Ligand Ace... 2 64
Integrin beta-1 Inhibitor R411 Family 33 44
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Caspase-3 Inhibitor 5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-di... 5 35
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
72 kDa type IV collagenase Inhibitor SC-74020 Family 1 21
Aldose reductase Inhibitor Inhibitor Idd 384 Family 1 3
Thymidylate synthase Inhibitor Sp-876 Family 7 117
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor N-(4-s... 12 92
Potassium voltage-gated channel subfamily A member 5 Ligand N-... 8 32
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor L-767679 Family 3 6
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Integrin beta-3 Inhibitor Lotrafiban Family 5 1
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
C-C chemokine receptor type 8 Ligand N-(4-phenylsulfamoyl-naph... 4 62
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Transient receptor potential cation channel subfamily V member... 1 5
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 1 14
D(2) dopamine receptor Ligand PD-168077 Family 6 5
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 1 8
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 1 1
Integrin beta-3 and Integrin alpha-V inhibitor SureCN5878245 f... 6 14
5-hydroxytryptamine receptor 6 ligand 1-(5-chloronaphthalen-1-... 1 5
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 5
Beta-secretase 1 inhibitor SureCN8292705 family 7 6
Neutrophil elastase inhibitor SureCN7448165 family 2 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
Pol polyprotein inhibitor Lysine Sulfonamide 11o family 2 6
Pol polyprotein inhibitor Lysine Sulfonamide 14a family 12 3
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 0
Cellular tumor antigen p53 inhibitor CHEMBL1554992 family 1 0
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
D(2) dopamine receptor and D(3) dopamine receptor ligand 1,1-d... 2 7
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 1 1
Cannabinoid receptor 2 ligand 4-methyl-3-piperidin-1-ylsulfony... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Pol polyprotein inhibitor AC1LAHQ3 family 13 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Cathepsin K and Cathepsin L1 inhibitor N-[1-(cyanomethylcarbam... 2 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-1-... 3 3
Protein-glutamine gamma-glutamyltransferase 2 and Coagulation ... 1 0
Angiotensin-converting enzyme inhibitor 1-[(2R,4R)-4-carboxy-2... 2 3
Bifunctional epoxide hydrolase 2 inhibitor 1-(2,4-dimethylphen... 4 8
Bifunctional epoxide hydrolase 2 inhibitor N-(2-chlorophenyl)-... 2 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
Cannabinoid receptor 2 ligand N-cyclohexyl-4-propan-2-yl-3-pyr... 2 2
C-C chemokine receptor type 2 ligand AGN-PC-03L0X5 family 13 0
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-037CNR f... 5 8
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-(benze... 2 2
Carbonic anhydrase 2 inhibitor N-[(4-nitrophenyl)methyl]-4-sul... 1 2
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-3-[[3-ox... 2 0
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-073KEE f... 4 0
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6373390 f... 2 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 2
Microbial collagenase inhibitor AGN-PC-074HDW family 4 0
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 1 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[ethyl-[2-(4... 1 1
Collagenase 3 inhibitor (2R)-2-[1-[(2-methylpropan-2-yl)oxycar... 4 2
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-009EMK... 2 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor KB-74... 2 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
Protein-glutamine gamma-glutamyltransferase 2 and Coagulation ... 3 2
Lethal(3)malignant brain tumor-like protein 3 and Lethal(3)mal... 1 0
Secreted frizzled-related protein 1 and Proto-oncogene Wnt-3 i... 2 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00236986 CHEMBL1782662 Bioactive SureCN7046671
CFAMM00237016 CHEMBL57134 Bioactive (2S)-2-(benzenesulfonamido)-3-[[2-(1-oxo-7-piperazin-1-yl-3,4-dihydroisoquinolin-2-yl)acetyl]amino]propanoic acid
CFAMM00237007 CHEMBL599138 Bioactive SureCN7052834
CFAMM00237012 CHEMBL163076 Bioactive (2S)-2-[(1-benzyl-5-oxopyrrolidine-2-carbonyl)amino]-3-[4-[(4-sulfamoylbenzoyl)amino]phenyl]propanoic acid
CFAMM00237004 CHEMBL598737 Bioactive SureCN382772
CFAMM00237018 CHEMBL599119 Bioactive SureCN382753
CFAMM00236995 DNC004290 Investigative Drug L-750034

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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