CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1379
Family Name Integrin beta-3 Inhibitor SB-208651 Family
No. of Seeds 9 No. of Other Members 28
Family Centroid CFAMM00237114 Functional Category Investigative Drug with Natural Product
Superfamily Integrin beta-3 Inhibitor SB-208651 Superfamily
Class Class 2096

Cousin Family NamesSeedsMembers
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Integrin beta-3 Inhibitor SKF-107260 Family 5 8
Integrin beta-3 Inhibitor Lotrafiban Family 5 1
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Caspase-1 inhibitor CHEMBL114791 family 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor 2-[7-[[4-(N'-... 7 15
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7345980... 4 6
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[1-ter... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-037CNR f... 5 8
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
Atrial natriuretic peptide receptor 1 and Atrial natriuretic p... 3 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-0BOW0P... 1 0
Prothrombin and Coagulation factor X inhibitor AC1NDIV9 family 1 0
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 12
NP (s)-methyl 2-(3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1... 11 3


External ID

Functional Category

Molecule Name

CFAMM00237092 CHEMBL163365 Bioactive (3S)-3-[1-tert-butyl-7-[2-(4-carbamimidoylphenyl)ethynyl]-2,5-dioxo-3H-1,4-benzodiazepin-4-yl]butanoic acid
CFAMM00237091 CHEMBL356020 Bioactive AGN-PC-03P5BC
CFAMM00237124 CHEMBL1270554 Bioactive AGN-PC-008AWQ
CFAMM00237115 CHEMBL151190 Bioactive SureCN6947925
CFAMM00237112 CHEMBL152156 Bioactive 2-[(2S)-8-[(4-carbamimidoylphenyl)carbamoyl]-3-oxo-4-(2-phenylethyl)-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
CFAMM00237104 CHEMBL163620 Bioactive (3S)-3-[7-[2-(4-carbamimidoylphenyl)ethynyl]-1-methyl-2,5-dioxo-3H-1,4-benzodiazepin-4-yl]butanoic acid
CFAMM00237094 CHEMBL18288 Bioactive AGN-PC-075SOD
CFAMM00237102 CHEMBL153162 Bioactive AGN-PC-0A2HIN
CFAMM00237114 DNC004298 Investigative Drug SB-208651

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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