CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1386
Family Name Integrin beta-3 Inhibitor L-756568 Family
No. of Seeds 8 No. of Other Members 59
Family Centroid CFAMM00237248 Functional Category Investigative Drug with Natural Product
Superfamily Integrin beta-3 Inhibitor L-756568 Superfamily
Class Class 82

Cousin Family NamesSeedsMembers
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Reverse transcriptase Inhibitor Atevirdine Family 4 55
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Histamine H3 receptor ligand (4S)-7-bromo-4-methyl-8-(1-propan... 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family 1 30
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 3
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
NS5B protein inhibitor AC1O5AET family 3 1
Collagenase 3 and A disintegrin and metalloproteinase with thr... 5 6
Glucagon receptor ligand 3-[[4-[(2S)-2-[5-(trifluoromethoxy)-1... 1 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Macrophage metalloelastase inhibitor (2S)-3-methyl-2-[[8-[3-(t... 2 6
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor 4-(benzyloxy... 1 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 2 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 1 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Histamine H3 receptor ligand SureCN1397929 family 1 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Aurora kinase A inhibitor SureCN3802792 family 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00237218 CHEMBL497025 Bioactive SureCN1552221
CFAMM00237198 CHEMBL57040 Bioactive (2S)-2-(benzenesulfonamido)-3-[[5-(2-piperidin-4-ylethoxy)-1H-indole-2-carbonyl]amino]propanoic acid
CFAMM00237223 CHEMBL359601 Bioactive 3-[[5-[2-(diaminomethylideneamino)oxyethoxy]-1H-indole-2-carbonyl]amino]-2-(phenylmethoxycarbonylamino)propanoic acid
CFAMM00237203 CHEMBL433785 Bioactive AGN-PC-075EZ1
CFAMM00237228 CHEMBL185580 Bioactive 3-[[5-[2-(diaminomethylideneamino)oxyethoxy]-1H-indole-2-carbonyl]amino]-2-[(4-methylphenyl)sulfonylamino]propanoic acid
CFAMM00237206 CHEMBL363098 Bioactive 3-[[5-[2-(diaminomethylideneamino)oxyethoxy]-1H-indole-2-carbonyl]amino]-2-[(7,7-dimethyl-4-bicyclo[2.2.1]heptanyl)sulfonylamino]propanoic acid
CFAMM00237232 CHEMBL186712 Bioactive AGN-PC-075FJ5
CFAMM00237248 DNC004314 Investigative Drug L-756568

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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