CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1388
Family Name 5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole Family
No. of Seeds 5 No. of Other Members 4
Family Centroid CFAMM00237270 Functional Category Investigative Drug
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily 3
Class Class 1116

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Glucagon receptor Ligand Dwlip-gcgrrx Family 5 26
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Amg 423 family 7 47
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Dihydroorotate dehydrogenase Inhibitor Nsc 665564 Family 2 83
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... 2 11
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 3 11
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Indoleamine 2,3-dioxygenase 1 Inhibitor N-[2-(indol-3-yl)ethyl... 2 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 6
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Urotensin-2 receptor Ligand Palosuran Family 4 4
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 7,12-d... 1 0
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Arachidonate 15-lipoxygenase Inhibitor PD-146176 Family 1 3
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 3-chloro-5-(2-methylq... 3 4
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Acetylcholinesterase Inhibitor Infractopicrin Family 1 1
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 3
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
Corticotropin-releasing factor receptor 1 ligand N-(cyclopropy... 2 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 4 5
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
Sodium-dependent serotonin transporter inhibitor SureCN6087392... 1 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 0
D(4) dopamine receptor and D(1A) dopamine receptor ligand 2-[[... 5 4
Prostaglandin G/H synthase 2 inhibitor SureCN6998947 family 1 1
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Sodium-dependent serotonin transporter inhibitor SureCN9171444... 2 0
Tyrosine-protein kinase ITK/TSK inhibitor (3Z)-3-(6-methylindo... 2 40
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 5 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Melanin-concentrating hormone receptor 2 and Sodium-dependent ... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
5-hydroxytryptamine receptor 6 ligand 9-(2-bromophenyl)sulfony... 2 0
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-methylsulfany... 1 1
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 2 2
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
D(4) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
CGMP-dependent protein kinase inhibitor AGN-PC-075INU family 1 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 5
Thromboxane-A synthase inhibitor AGN-PC-07BYVF family 1 0
Thymidylate synthase inhibitor AGN-PC-00EUGY family 2 7
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
Potassium voltage-gated channel subfamily A member 5 and Volta... 2 4
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 1 1
Nonstructural protein 1 and Lysine-specific demethylase 4E inh... 1 0
Cytochrome P450 2C19 inhibitor CHEMBL1449918 family 1 0
Hexokinase and Farnesyl pyrophosphate synthase inhibitor AC1NQ... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Nociceptin receptor ligand AGN-PC-07C3R0 family 1 0
(4aR,13bS,14aR)-3,4,4a,5,7,8,13,13b,14,14a-decahydro-5,14-etha... 2 0
8'-fluoro-6'-methyl-2,3,4,5',6',9-hexahydrodispiro[beta-carbol... 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00237268 CHEMBL77234 Bioactive AGN-PC-02YBLV
CFAMM00237273 DNC004343 Investigative Drug 1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole
CFAMM00237272 DNC004339 Investigative Drug 7-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole
CFAMM00237270 DNC004320 Investigative Drug 8-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole
CFAMM00237269 DNC004318 Investigative Drug 6-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

25231 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543