CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1389
Family Name Endothelin B receptor and Endothelin-1 receptor Ligand PD-163140 Family
No. of Seeds 9 No. of Other Members 13
Family Centroid CFAMM00237300 Functional Category Investigative Drug with Natural Product
Superfamily Endothelin B receptor and Endothelin-1 receptor Ligand PD-163140 Superfamily
Class Class 1704

Cousin Family NamesSeedsMembers
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
Hidrosmin family 14 61
taste receptor Ligand Cynarin Family 6 124
DNA topoisomerase 2-beta Inhibitor TOP-53 Family 2 12
Endothelin-1 receptor Ligand PD156707 Family 41 211
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Cytochrome P450 3A4 Inhibitor Hinokinin Family 2 10
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
72 kDa type IV collagenase Inhibitor Lithospermic Acid Family 1 0
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 6 6
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Endothelin-1 receptor ligand SureCN8117947 family 1 3
Endothelin-1 receptor and Endothelin B receptor ligand SureCN7... 2 2
Endothelin-1 receptor ligand SureCN7952886 family 1 0
Endothelin-1 receptor ligand [4-(1,3-benzodioxol-5-yl)-2-(4-me... 1 0
Endothelin B receptor and Endothelin-1 receptor ligand AGN-PC-... 2 0


External ID

Functional Category

Molecule Name

CFAMM00237279 CHEMBL450337 Bioactive SureCN8184856
CFAMM00237286 CHEMBL320183 Bioactive AGN-PC-00P5UX
CFAMM00237285 CHEMBL68269 Bioactive SureCN7955161
CFAMM00237294 CHEMBL316523 Bioactive SureCN8189982
CFAMM00237293 CHEMBL302974 Bioactive SureCN7956654
CFAMM00237282 CHEMBL103846 Bioactive AGN-PC-00P5V0
CFAMM00237298 CHEMBL320839 Bioactive AGN-PC-00P5UY
CFAMM00237297 CHEMBL307330 Bioactive SureCN7956457
CFAMM00237300 DNC004321 Investigative Drug PD-163140

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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