CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1390
Family Name Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-12909 Family
No. of Seeds 80 No. of Other Members 110
Family Centroid CFAMM00237355 Functional Category Investigative Drug
Superfamily Biogenic amine receptor Diphenhydramine Phendimetrazine Diphenylpyraline Superfamily
Class Class 231

Cousin Family NamesSeedsMembers
Opioid receptor ligand synthetic opioid methadone analog Dextr... 2 108
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Histamine H1 receptor Ligand Terfenadine Family 3 50
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96
Alpha-2 adrenergic receptor ligand opiate Meperidine Family 13 76
Histamine H1 receptor Ligand Clemastine Family 5 76
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Histamine H1 receptor Ligand Diphenhydramine Family 5 75
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Sodium channel protein type 5 subunit alpha Ligand Hexylcaine ... 4 94
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Cocain... 13 136
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Substance-P receptor Ligand Ezlopitant Family 10 207
VTP-27999 family 24 23
Muscarinic acetylcholine receptor Ligand Umeclidinium Family 7 50
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Choline kinase alpha Inhibitor Hemicholinium-3 Family 4 0
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Substance-P receptor Ligand L-733060 Family 19 71
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Substance-P receptor Ligand SCH-388714 Family 26 8
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Sodium-dependent noradrenaline transporter Inhibitor (r)-1-((s... 3 8
Cholinesterase Inhibitor 4-[4-(benzyloxy)piperidino]butyl-3-fl... 5 18
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 5 14
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
Potassium voltage-gated channel subfamily H member 2 Ligand [1... 2 23
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Muscarinic acetylcholine receptor M1 and Sodium-dependent dopa... 2 13
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-ri... 5 12
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
Sodium-dependent dopamine transporter and Sodium-dependent nor... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 4 19
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 12
Substance-P receptor ligand (1S,2R)-2-[(1R)-1-[3,5-bis(trifluo... 12 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 11
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 1 2
Sigma non-opioid intracellular receptor 1 ligand (1R)-1'-benzy... 7 27
Sigma non-opioid intracellular receptor 1 ligand 2-[(3R)-1'-(c... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-076TWX... 8 5
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 1
Substance-P receptor ligand (2S)-3-[[3,5-bis(trifluoromethyl)p... 1 4
Vesicular acetylcholine transporter inhibitor BENZOVESAMICOL f... 7 4
Peptidyl-prolyl cis-trans isomerase FKBP1A and Peptidyl-prolyl... 4 27
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 18
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 1 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 7 0
Substance-P receptor ligand 1-[4-[[3,5-bis(trifluoromethyl)phe... 5 8
Substance-P receptor ligand 4-[[3,5-bis(trifluoromethyl)phenyl... 2 1
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Sigma non-opioid intracellular receptor 1 ligand SureCN5315520... 3 11
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Sigma non-opioid intracellular receptor 1 ligand N-benzyl-2-[(... 1 5
Estrogen receptor and Estrogen receptor beta ligand (2R,3R,4S)... 3 0
Substance-P receptor ligand 3-[bis(4-fluorophenyl)methyl]-1-[(... 5 2
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Transporter and 5-hydroxytryptamine receptor 2C ligand CHEMBL1... 5 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 0
Sodium-dependent dopamine transporter and Transporter inhibito... 1 6
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 6 3
Muscarinic acetylcholine receptor M3 ligand AGN-PC-005QPZ family 1 0
Muscarinic acetylcholine receptor M3 ligand 3-[8-methyl-8-(2-p... 3 0
Histamine H3 receptor ligand SureCN6071181 family 2 1
Substance-P receptor ligand 1-[[(1R,2R,3S)-3-[[3,5-bis(trifluo... 4 3
Transporter and Sodium-dependent serotonin transporter inhibit... 1 5
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Sodium-dependent serotonin transporter and Alpha-2A adrenergic... 2 2
Substance-P receptor ligand AGN-PC-03NGZP family 3 0
Substance-P receptor ligand (1R,2S,3S)-3-[(1R)-1-[3,5-bis(trif... 8 0
Sodium-dependent dopamine transporter and Transporter inhibito... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Substance-P receptor and Sodium-dependent serotonin transporte... 6 1
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00E... 7 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Substance-P receptor ligand 1-[(3S,4R)-3-[(1R)-1-[3,5-bis(trif... 9 0
Substance-P receptor ligand (5S)-5-[(3S,4R)-3-[(1R)-1-[3,5-bis... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Substance-P receptor ligand SureCN8415737 family 3 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 0
Sigma non-opioid intracellular receptor 1 ligand SureCN7425449... 2 0
Substance-P receptor ligand methyl 2-[(2S,3S)-2-[[3,5-bis(trif... 1 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 12
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 0
Vesicular acetylcholine transporter inhibitor (1R,2R)-2-spiro[... 3 2
C-C chemokine receptor type 5 ligand AC1LAKN8 family 4 5
Histamine H1 receptor and 5-hydroxytryptamine receptor 2C liga... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 3
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Substance-P receptor ligand AGN-PC-02K8GG family 1 1
Sodium-dependent dopamine transporter and Sigma non-opioid int... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Cathepsin B and Cathepsin S inhibitor (4S,5R)-4-(2,3-dimethylp... 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Substance-P receptor ligand SureCN8912140 family 2 12
Cannabinoid receptor 2 ligand SureCN4472215 family 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0793IB... 2 0
Substance-P receptor ligand (3aR,4R,5S,7aS)-5-[(1R)-1-[3,5-bis... 4 0
Renin inhibitor SureCN1858210 family 9 0
Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... 1 0
Substance-P receptor and Voltage-dependent L-type calcium chan... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
Histamine H1 receptor and 5-hydroxytryptamine receptor 2A liga... 1 0
Sodium-dependent dopamine transporter inhibitor 2-(4-nitrophen... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 1
Sodium- and chloride-dependent GABA transporter 1 inhibitor (3... 17 43
Sodium- and chloride-dependent GABA transporter 1 inhibitor Su... 3 0
Sigma non-opioid intracellular receptor 1 and Kappa-type opioi... 2 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 1-... 1 0
Sigma non-opioid intracellular receptor 1 ligand tert-butyl 2-... 1 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 5
Cytochrome P450 2D6 and Sodium channel protein type 1 subunit ... 1 1
Putative NP ZINC04061066 Family 18 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00237352 CHEMBL143612 Bioactive 1,4-bis(2-benzhydryloxyethyl)piperazine
CFAMM00237365 CHEMBL83296 Bioactive N'-[2-[bis(4-fluorophenyl)methoxy]ethyl]-N,N'-dimethyl-N-(3-phenylpropyl)ethane-1,2-diamine
CFAMM00237319 CHEMBL163272 Bioactive 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(naphthalen-2-ylmethyl)piperazine
CFAMM00237378 CHEMBL511950 Bioactive AGN-PC-02TNAV
CFAMM00237358 CHEMBL466750 Bioactive AGN-PC-04S2UT
CFAMM00237364 CHEMBL140054 Bioactive (2S,5R)-1-(2-benzhydryloxyethyl)-2,5-dimethyl-4-(3-phenylpropyl)piperazine
CFAMM00237377 CHEMBL152779 Bioactive (2S)-1-[4-(2-benzhydryloxyethyl)piperazin-1-yl]-3-phenylpropan-2-ol;(E)-but-2-enedioic acid
CFAMM00237344 CHEMBL341692 Bioactive [3-[4-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperazin-1-yl]-1-phenylpropyl] decanoate
CFAMM00237384 CHEMBL202860 Bioactive (2R)-1-[4-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperidin-1-yl]-4-phenylbutan-2-ol;oxalic acid
CFAMM00237324 CHEMBL28149 Bioactive (2S)-1-[4-(2-benzhydryloxyethyl)piperazin-1-yl]-3-phenylpropan-2-ol
CFAMM00237350 CHEMBL469165 Bioactive AGN-PC-04S2US
CFAMM00237317 CHEMBL205005 Bioactive AGN-PC-00C8XI
CFAMM00237356 CHEMBL142674 Bioactive LR 1143
CFAMM00237403 CHEMBL162828 Bioactive 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-naphthalen-1-ylethyl)piperazine
CFAMM00237310 CHEMBL1628630 Bioactive GBR-12935
CFAMM00237383 CHEMBL1161985 Bioactive 3-[2-[bis(4-fluorophenyl)methoxy]ethyl]-6-[(E)-3-phenylprop-2-enyl]-3,6-diazabicyclo[3.1.1]heptane;(E)-but-2-enedioic acid
CFAMM00237396 CHEMBL28897 Bioactive AGN-PC-04S2V0
CFAMM00237409 CHEMBL149013 Bioactive 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-[3-(3-methoxyphenyl)propyl]piperazine
CFAMM00237316 CHEMBL29286 Bioactive AGN-PC-073HQ1
CFAMM00237382 CHEMBL1161984 Bioactive 3-[2-[bis(4-fluorophenyl)methoxy]ethyl]-6-[(E)-3-(2-methylphenyl)prop-2-enyl]-3,6-diazabicyclo[3.1.1]heptane;(E)-but-2-enedioic acid
CFAMM00237423 CHEMBL380406 Bioactive (2S)-1-[4-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperidin-1-yl]-3-phenylpropan-2-ol;oxalic acid
CFAMM00237315 CHEMBL112280 Bioactive Gbr-13069
CFAMM00237422 CHEMBL204530 Bioactive (2R)-1-[4-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperidin-1-yl]-3-phenylpropan-2-ol;oxalic acid
CFAMM00237428 CHEMBL383464 Bioactive (2S)-1-[4-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperidin-1-yl]-4-phenylbutan-2-ol;oxalic acid
CFAMM00237340 CHEMBL149565 Bioactive SureCN7723755
CFAMM00237333 CHEMBL381842 Bioactive (2S)-1-[4-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperidin-1-yl]-3-phenylpropan-2-amine;oxalic acid
CFAMM00237406 CHEMBL102119 Bioactive Piperazine, 1,4-bis[2-[bis(4-fluorophenyl)methoxy]ethyl]-
CFAMM00237421 CHEMBL143823 Bioactive 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-[(E)-3-phenylprop-2-enyl]-1,4-diazepane
CFAMM00237386 CHEMBL1161983 Bioactive 3-[2-[bis(4-fluorophenyl)methoxy]ethyl]-6-(1H-inden-2-ylmethyl)-3,6-diazabicyclo[3.1.1]heptane;(E)-but-2-enedioic acid
CFAMM00237355 DNC004324 Investigative Drug GBR-12909

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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