CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1397
Family Name Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihydro-quinoline Family
No. of Seeds 5 No. of Other Members 82
Family Centroid CFAMM00237588 Functional Category Investigative Drug with Natural Product
Superfamily Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihydro-quinoline Superfamily
Class Class 1440

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Calmodulin Inhibitor Aprindine Family 1 4
Histamine H1 receptor Ligand Antazoline Family 5 57
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Motilin receptor Ligand GSK962040 Family 30 457
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
NMDA receptor Ligand Aptiganel Hcl Family 2 82
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 5 65
5-hydroxytryptamine receptor 6 Ligand 4-(1h-inden-1-ylmethyl)-... 5 99
Potassium voltage-gated channel subfamily A member 3 Ligand CP... 4 26
5-hydroxytryptamine receptor 5A Ligand N,4-dimethyl-3,4-dihydr... 8 51
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3,... 3 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
5-hydroxytryptamine receptor 6 Ligand [2-(3h-indol-1-yl)-ethyl... 2 7
Transient receptor potential cation channel subfamily V member... 6 33
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 8 32
Androgen receptor Ligand YM-175735 Family 30 129
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Aromatase Inhibitor 3-amino-4'-amino-trans-stilbene Family 5 47
Kinesin-like protein KIF11 Inhibitor N-(4'-bromo-3,3'-difluoro... 2 0
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 3 13
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 2 9
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
Histamine H3 receptor Ligand (r)-1-(4-nitrophenethyl)-2-methyl... 16 38
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmaleimid... 2 11
Sphingosine kinase 2 Inhibitor (r)-2-amino-3-(4-octylphenylami... 1 16
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 0
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 3
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
Nitric oxide synthase, brain Inhibitor N*1*-(5-methyl-2-nitro-... 1 19
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
Acetylcholinesterase Inhibitor (3-hydroxy-2-methyl-phenyl)-tri... 4 25
Tyrosinase Inhibitor 1-hydroxy-3-(4-(trifluoromethyl)phenyl)ur... 2 3
Trypsin Inhibitor 1,3-di-p-tolyl-[1,3]diazetidine-2,4-dione Fa... 2 16
DNA topoisomerase Inhibitor 6-(naphthalen-2-ylamino)-1h-pyrimi... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 4
Progesterone receptor ligand 7-fluoro-2,2,4-trimethyl-8-nitro-... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Sodium-dependent noradrenaline transporter inhibitor 3-[1-(2-f... 2 13
5-hydroxytryptamine receptor 2A ligand AGN-PC-075LXD family 4 4
Prelamin-A/C and Alpha-2A adrenergic receptor ligand AMITRAZ f... 1 5
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-[1-adama... 4 23
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
5-hydroxytryptamine receptor 7 ligand 1-[2-(4-nitrophenyl)phen... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-[[4... 7 11
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor 1-(3,5... 2 0
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
Progesterone receptor ligand 3-(2-sulfanylidenespiro[1H-indole... 1 0
Progesterone receptor ligand AGN-PC-074PCH family 2 1
Steroidogenic factor 1 and Nuclear receptor subfamily 5 group ... 1 13
Androgen receptor ligand 4-[(1R,5R)-3-hydroxy-3-methyl-8-azabi... 8 7
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 1 0
Histamine H3 receptor ligand SureCN3052824 family 4 14
Carbonic anhydrase 2 inhibitor 1-(dimethylamino)-4-[(Z)-C-meth... 1 0
5-hydroxytryptamine receptor 2B and Prostaglandin G/H synthase... 1 16
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 12
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 4
Squalene monooxygenase inhibitor 3-[[[(E)-6,6-dimethylhept-2-e... 1 0
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 1 1
Cholinesterase inhibitor 10-[[(1R,9aR)-2,3,4,6,7,8,9,9a-octahy... 1 0
Androgen receptor ligand 1-[4-[3-[4-[(3,3-dimethyl-2-oxobutyl)... 1 2
Metabotropic glutamate receptor 2 ligand 4-[4-(methylamino)phe... 1 4
Cytochrome P450 2C9 and Cytochrome P450 2D6 inhibitor N'-(4-he... 1 0
3,3,5,5-tetramethyl-N-phenyl-1,2,4,6,7,8-hexahydronaphthalen-2... 2 0
3,3,5,5,7,10c-hexamethyl-1,2,3,5,5a,6,10b,10c-octahydrocyclope... 1 0
2-(6-methyl-2-oxo-4-phenyl-1H-quinolin-3-yl)acetate NP ZINC002... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00237587 CHEMBL93690 Bioactive AGN-PC-00PB7J
CFAMM00237652 CHEMBL117465 Bioactive SureCN4183779
CFAMM00237635 CHEMBL117586 Bioactive SureCN4175883
CFAMM00237597 CHEMBL92750 Bioactive AGN-PC-00PB7M
CFAMM00237588 DNC004348 Investigative Drug 2,2,4-Trimethyl-6-phenyl-1,2-dihydro-quinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

38798 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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