CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1401
Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3-nitro-phenyl)-6-pyridin-4-ylmethyl-quinoline Family
No. of Seeds 4 No. of Other Members 22
Family Centroid CFAMM00237763 Functional Category Investigative Drug
Superfamily cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Ribosyldihydronicotinamide dehydrogenase [quinone] Binder Superfamily
Class Class 2102

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Transient receptor potential cation channel subfamily V member... 15 158
Glucagon receptor Ligand Dwlip-gcgrrx Family 5 26
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
D(3) dopamine receptor Ligand SB-277011 Family 13 178
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
NF-kappa-B Inhibitor 2-nitro-n-(quinolin-8-yl)benzenesulfonami... 2 3
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 3
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 3-fluoro-5-(2-methylq... 3 2
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Metabotropic glutamate receptor 1 Ligand (e)-4,4-dimethyl-1-qu... 2 2
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Trypsin Inhibitor 4-(5-nitro-indol-1-ylmethyl)-benzamidine Family 2 0
Histone deacetylase Inhibitor ST-5732 Family 8 6
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 5 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloro-4-fl... 6 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
Hepatocyte growth factor receptor ligand AGN-PC-08XYH0 family 8 4
Hepatocyte growth factor receptor ligand AGN-PC-08XYH3 family 1 0
Hepatocyte growth factor receptor ligand AGN-PC-09M1N4 family 2 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SQ6 family 3 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Glucocorticoid receptor ligand 1,1,1-trifluoro-2-[(1-methyl-3,... 3 4
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 4 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Prostaglandin D2 receptor 2 ligand SureCN317401 family 3 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 2 2
Capsid scaffolding protein inhibitor AC1O583J family 5 1
Thymidylate synthase inhibitor AGN-PC-00EUGY family 2 7
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Transient receptor potential cation channel subfamily V member... 1 0
Lysine-specific demethylase 4E and Lethal(3)malignant brain tu... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00237742 CHEMBL351613 Bioactive 8-(3-nitrophenyl)-6-pyridin-3-yl-1,7-naphthyridine
CFAMM00237746 CHEMBL351500 Bioactive 8-(3-nitrophenyl)-6-prop-2-enyl-1,7-naphthyridine
CFAMM00237763 DNC004366 Investigative Drug 8-(3-Nitro-phenyl)-6-pyridin-4-ylmethyl-quinoline
CFAMM00237756 DNC012499 Investigative Drug 8-(3-Nitro-phenyl)-6-phenyl-[1,7]naphthyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27256 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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