CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1409
Family Name Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibitor A-420983 Family
No. of Seeds 4 No. of Other Members 32
Family Centroid CFAMM00237924 Functional Category Investigative Drug
Superfamily Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibitor A-420983 Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
Ibrutinib family 2 27
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
Receptor tyrosine-protein kinase erbB-2 and Insulin-like growt... 4 10
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Hepatocyte growth factor receptor ligand 5-[[6-(3-hydroxypheny... 2 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 3
DNA gyrase subunit B inhibitor N-ethyl-5-[6-methoxy-5-(2-oxo-3... 3 0
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-[2-... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 5-[(7S... 6 1
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Insulin-like growth factor 1 receptor ligand SureCN6107989 family 1 0
Receptor tyrosine-protein kinase erbB-2 and Insulin-like growt... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00237925 CHEMBL43773 Bioactive Pyrazolo[3,4-d]pyrimidine 15
CFAMM00237924 DNC004381 Investigative Drug A-420983
CFAMM00237950 DNC006011 Investigative Drug A-641359
CFAMM00237926 DNC006013 Investigative Drug A-770041

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26831 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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