CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID141
Family Name Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 Inhibitor AG490 Family
No. of Seeds 6 No. of Other Members 40
Family Centroid CFAMM00182123 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 Inhibitor AG490 Superfamily
Class Class 1429

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Alpha-1 adrenergic receptor ligand arylethanolamine derivative... 4 37
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Dopamine receptor ligand L-Tyrosine derivative Levodopa Family 4 59
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Zucapsacin family 7 177
Thymopentin family 20 133
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Kynureninase Inhibitor 3-hydroxyhippuric Acid Family 1 9
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Scytalone dehydratase Inhibitor 5-fluoro-2-hydroxy-n-isopropyl... 3 14
Epidermal growth factor receptor Ligand 2-cyano-3-(3,4-dihydro... 1 0
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Lethal factor Inhibitor N-(3,4,5-trihydroxyphenethyl)oleamide ... 1 3
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 7 18
Macrophage migration inhibitory factor Inhibitor 2-(4-hydroxys... 8 19
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Tyrosinase Inhibitor N-(2,4-dihydroxybenzyl)-3,4-dihydroxybenz... 3 2
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Transient receptor potential cation channel subfamily V member... 2 6
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 5 3
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 4 2
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-01Z... 2 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 3 8
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 6 2
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor (E)-2... 2 1
Pol polyprotein inhibitor AC1LA3AI family 5 9
Coagulation factor X inhibitor 3-[4-[[(E)-3-[3-(diaminomethyli... 4 6
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
Glutamate receptor ionotropic, NMDA 2B ligand AGN-PC-076B5T fa... 1 0
Sigma non-opioid intracellular receptor 1 ligand N-(1-benzylpi... 1 0
Beta-lactamase inhibitor CHEMBL1316873 family 1 1
Calpain-1 catalytic subunit inhibitor (2E)-2-[(3,4-dihydroxyph... 4 0
Adenosine receptor A2a and Adenosine receptor A2b ligand N-(2-... 3 0
Amino Acids and Derivatives Metabolite Caffeoyl aspartic acid ... 1 0
Phenylpropenes Metabolite N1,N5,N10,N14-Tetra-trans-p-coumaroy... 1 0
N-formyl-2-(4-hydroxyphenyl)acetamide NP Agn-pc-04a0ox Family 1 1
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
7-[(1R,2R)-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]-N-... 1 0
NP (z)-methyl 4-(4-hydroxy-3-methoxybenzylidene)-1-(3-methoxyp... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00182140 CHEMBL2336363 Bioactive (E)-N-benzyl-3-(3-hydroxyphenyl)prop-2-enamide
CFAMM00182114 CHEMBL67291 Bioactive (E)-N-benzyl-3-(3,4-dihydroxyphenyl)prop-2-enamide
CFAMM00182145 CHEMBL67498 Bioactive Caffeic Acid Phenethyl Amide
CFAMM00182119 CHEMBL2336337 Bioactive (E)-N-benzyl-3-(4-hydroxyphenyl)prop-2-enamide
CFAMM00182123 DNC000170 Investigative Drug AG490

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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