CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1414
Family Name Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dimethoxy-benzamide Family
No. of Seeds 1 No. of Other Members 110
Family Centroid CFAMM00238074 Functional Category Investigative Drug with Natural Product
Superfamily Cytochrome P450 1B1 and Liver carboxylesterase 1 Binder Superfamily
Class Class 1482

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Histamine H1 receptor Ligand Tranilast Family 5 125
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Liver carboxylesterase 1 Inhibitor CI-976 Family 1 32
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
Substance-K receptor Ligand MEN-14933 Family 13 154
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor 6... 2 0
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Gamma-aminobutyric acid receptor Ligand 2-(2-amino-phenyl)-6-m... 4 23
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1352632 ... 1 25
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 4 4
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 11 26
Transient receptor potential cation channel subfamily V member... 1 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Androgen receptor ligand trifluoromethyl 10-methoxy-4-methyl-2... 2 57
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 8 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Sterol O-acyltransferase 1 inhibitor 2-methyltetradecan-2-yl 3... 2 1
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Hepatocyte growth factor receptor ligand 2-[(2-fluorophenyl)me... 6 11
Glucose-dependent insulinotropic receptor ligand tert-butyl 4-... 1 0
Acyl-CoA:cholesterol acyltransferase and Sterol O-acyltransfer... 1 0
Major prion protein and Microtubule-associated protein tau inh... 2 10
Nuclear receptor ROR-gamma and Retinal dehydrogenase 1 ligand ... 1 8
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0
Cytochrome P450 2D6 inhibitor 2-[(3-butoxyphenoxy)methyl]-3-me... 1 0
Acetylcholinesterase inhibitor 4-[(2-methoxyanilino)methyl]-[1... 2 4
Multidrug resistance protein 1 inhibitor 3,4,5-trimethoxy-N-(2... 4 0
Aldo-keto reductase family 1 member C3 and Aldo-keto reductase... 1 0
Inosine-5'-monophosphate dehydrogenase 2 and Inosine-5'-monoph... 1 14
Tyrosine-protein kinase ABL1 inhibitor N-(4-bromophenyl)-2-(5-... 1 3
Malate dehydrogenase, mitochondrial and Lactate dehydrogenase ... 1 1
Urokinase-type plasminogen activator and Tissue-type plasminog... 1 0
Nuclear receptor ROR-gamma and Lethal factor ligand NSC211094 ... 1 3
3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-1H-indol-2-one ... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00238074 DNC004397 Investigative Drug N-(2,4-Dimethoxy-phenyl)-3,5-dimethoxy-benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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