CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1417
Family Name Collagenase 3 and Interstitial collagenase Inhibitor 3-(4-methoxy-benzenesulfonyl)-hexane-1-thiol Family
No. of Seeds 12 No. of Other Members 76
Family Centroid CFAMM00238220 Functional Category Investigative Drug
Superfamily Collagenase 3 and Interstitial collagenase Inhibitor 3-(4-methoxy-benzenesulfonyl)-hexane-1-thiol Superfamily
Class Class 2108

Cousin Family NamesSeedsMembers
Neutrophil elastase Inhibitor CE-1037 Family 1 4
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 6-ph... 1 18
Amyloid beta A4 protein Inhibitor 2,5-bis(4-methoxyphenyl)thio... 3 31
Leukotriene A-4 hydrolase Inhibitor 1-butoxy-4-phenoxybenzene ... 3 85
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 1-(3-... 2 16
Androgen receptor Ligand 4-(isopropylthio)-2-methoxybenzonitri... 9 3
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-methoxybenzenemethan... 2 26
Prostaglandin G/H synthase 1 Inhibitor Acetic Acid 2-hept-2-yn... 6 6
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 5 18
Carbonic anhydrase 2 inhibitor AGN-PC-0022OE family 2 3
Prostaglandin G/H synthase 2 inhibitor [4-[3-(4-methylsulfonyl... 3 10
72 kDa type IV collagenase and Stromelysin-1 inhibitor 3-cyclo... 5 0
Amine oxidase [flavin-containing] A inhibitor BW 1370U87 family 3 29
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Carbonic anhydrase 12 and Carbonic anhydrase 9 inhibitor 3-(4-... 3 4
Disintegrin and metalloproteinase domain-containing protein 17... 3 2
Amine oxidase [flavin-containing] A inhibitor 2-ethoxyphenoxat... 1 5
Replicase polyprotein 1a inhibitor 4-({4-[(2,3,3-trichloroacry... 1 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 1


External ID

Functional Category

Molecule Name

CFAMM00238218 CHEMBL172588 Bioactive 3-(4-methoxyphenyl)sulfonyl-4-phenylbutane-1-thiol
CFAMM00238187 CHEMBL402747 Bioactive 3-{[4-(But-2-Yn-1-Yloxy)phenyl]sulfonyl}propane-1-Thiol
CFAMM00238253 CHEMBL253686 Bioactive thiol-aryl sulfone, 8a
CFAMM00238249 DNC004460 Investigative Drug 3-(4-Methoxy-benzenesulfonyl)-cyclopentanethiol
CFAMM00238201 DNC004637 Investigative Drug 3-(4-Methoxy-benzenesulfonyl)-pentane-1-thiol
CFAMM00238163 DNC004443 Investigative Drug 3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol
CFAMM00238247 DNC004405 Investigative Drug 3-(4-Methoxy-benzenesulfonyl)-cyclohexanethiol
CFAMM00238154 DNC004453 Investigative Drug 3-(4-Methoxy-benzenesulfonyl)-propane-1-thiol
CFAMM00238199 DNC004632 Investigative Drug 1-(4-Methoxy-benzenesulfonyl)-heptane-3-thiol
CFAMM00238220 DNC004623 Investigative Drug 3-(4-Methoxy-benzenesulfonyl)-hexane-1-thiol
CFAMM00238204 DNC004638 Investigative Drug 4-(4-Methoxy-benzenesulfonyl)-butane-2-thiol
CFAMM00238167 DNC004449 Investigative Drug 3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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