CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1436
Family Name Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-(biphenyl-4-yloxy)-heptanoic Acid Hydroxyamide Family
No. of Seeds 4 No. of Other Members 42
Family Centroid CFAMM00238904 Functional Category Investigative Drug with Natural Product
Superfamily Histone deacetylase 1 and Histone deacetylase 2 Binder Superfamily
Class Class 2041

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Muscarinic acetylcholine receptor M3 Ligand Darifenacin Family 3 17
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-ph... 1 3
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Interstitial collagenase Inhibitor N-hydroxy-4-(4-methoxy-phen... 6 4
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Matrix metalloproteinase-9 and Collagenase 3 Inhibitor 4-amino... 1 8
Histone deacetylase 1 Inhibitor N-hydroxy-8-(2-methoxyphenyl)-... 2 14
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Histone deacetylase 4 Inhibitor N-hydroxy-9h-xanthene-9-carbox... 1 0
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Melatonin receptor type 1A ligand N-[(7-methoxynaphthalen-1-yl... 1 0
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Kinesin-like protein KIF11 inhibitor 2-amino-5-(4-methoxypheny... 1 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 3
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
Dehydrosqualene synthase inhibitor AGN-PC-077O7S family 1 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 12
Trace amine-associated receptor 1 ligand SureCN13886619 family 1 1
Free fatty acid receptor 1 ligand 3-[4-[2-[2-(cyanomethoxy)phe... 1 2
Disintegrin and metalloproteinase domain-containing protein 17... 6 6
Disintegrin and metalloproteinase domain-containing protein 17... 2 2
Stromelysin-1 and 72 kDa type IV collagenase inhibitor AGN-PC-... 1 0
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 2
Interleukin-8 inhibitor 2-[2-(2-fluorophenoxy)phenyl]-N-methyl... 1 0
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
Stromelysin-1 inhibitor N-hydroxy-2-[3-[4-(4-methoxyphenyl)phe... 2 1
Lysosomal alpha-glucosidase inhibitor MLS000587024 family 1 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-02TTXV family 1 0
3-azaniumyl-3-(4-butoxyphenyl)butanoate NP 3-amino-3-(4-butoxy... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00238882 CHEMBL441664 Bioactive N-[(7-methoxynaphthalen-1-yl)methoxy]butanamide
CFAMM00238874 CHEMBL115812 Bioactive 191228-04-3
CFAMM00238904 DNC004461 Investigative Drug 7-(Biphenyl-4-yloxy)-heptanoic acid hydroxyamide
CFAMM00238896 DNC006957 Investigative Drug N-hydroxy-7-(naphthalen-2-yloxy)heptanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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