CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1452
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 1B Ligand 1-naphthalen-2-yl-piperazine Family
No. of Seeds 9 No. of Other Members 67
Family Centroid CFAMM00239137 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 1B Ligand 1-naphthalen-2-yl-piperazine Superfamily
Class Class 2121

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Serotonin re-uptake inhibitor Dibenzazepine Clomipramine Family 2 23
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Calmodulin Inhibitor Aprindine Family 1 4
Histamine H1 receptor Ligand Antazoline Family 5 57
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
WAY-162545 family 2 4
NMDA receptor Ligand Aptiganel Hcl Family 2 82
Potassium voltage-gated channel subfamily A member 3 Ligand CP... 4 26
5-hydroxytryptamine receptor 5A Ligand N,4-dimethyl-3,4-dihydr... 8 51
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3,... 3 4
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
Alpha-2A adrenergic receptor Ligand 7-nitro-1,2,3,4-tetrahydro... 6 31
5-hydroxytryptamine receptor 6 Ligand [2-(3h-indol-1-yl)-ethyl... 2 7
Transient receptor potential cation channel subfamily V member... 6 33
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 8 32
Androgen receptor Ligand YM-175735 Family 30 129
Aromatase Inhibitor 3-amino-4'-amino-trans-stilbene Family 5 47
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 2 9
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
Histamine H3 receptor Ligand (r)-1-(4-nitrophenethyl)-2-methyl... 16 38
Cholinesterase Inhibitor (-)-debromoflustramine B Family 2 14
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Sphingosine kinase 2 Inhibitor (r)-2-amino-3-(4-octylphenylami... 1 16
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
Nitric oxide synthase, brain Inhibitor N*1*-(5-methyl-2-nitro-... 1 19
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
Acetylcholinesterase Inhibitor (3-hydroxy-2-methyl-phenyl)-tri... 4 25
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 4
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
Progesterone receptor ligand 7-fluoro-2,2,4-trimethyl-8-nitro-... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Sodium-dependent noradrenaline transporter inhibitor 3-[1-(2-f... 2 13
5-hydroxytryptamine receptor 2A ligand AGN-PC-075LXD family 4 4
Muscarinic acetylcholine receptor M3 ligand AGN-PC-09QGYO family 11 14
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Melanin-concentrating hormone receptor 1 ligand 1-[2-[4-(3-cya... 3 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 0
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-[1-adama... 4 23
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 3
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Sigma non-opioid intracellular receptor 1 ligand 1-[(3-nitroph... 4 2
5-hydroxytryptamine receptor 7 ligand 1-[2-(4-nitrophenyl)phen... 1 0
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Chitin synthase 1 inhibitor AC1O53V7 family 9 0
C-C chemokine receptor type 3 ligand AGN-PC-073RIP family 2 4
D(1A) dopamine receptor and D(3) dopamine receptor ligand 4-[(... 2 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Progesterone receptor ligand AGN-PC-074PCH family 2 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Steroidogenic factor 1 and Nuclear receptor subfamily 5 group ... 1 13
Androgen receptor ligand 4-[(1R,5R)-3-hydroxy-3-methyl-8-azabi... 8 7
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 1 0
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
Histamine H3 receptor ligand SureCN3052824 family 4 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 7 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 4
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
Lysosomal Pro-X carboxypeptidase and Glutamate receptor ionotr... 1 0
Squalene monooxygenase inhibitor 3-[[[(E)-6,6-dimethylhept-2-e... 1 0
Cholinesterase inhibitor 10-[[(1R,9aR)-2,3,4,6,7,8,9,9a-octahy... 1 0
Androgen receptor ligand 1-[4-[3-[4-[(3,3-dimethyl-2-oxobutyl)... 1 2
Sodium-dependent dopamine transporter inhibitor AGN-PC-006XV1 ... 3 0
C-C chemokine receptor type 3 ligand CHEMBL300905 family 2 1
Alkaloids and Derivatives Metabolite (+)-Aspidospermidine Family 1 5
Acenes Metabolite 1-Aminopyrene Family 1 63
3,3,5,5-tetramethyl-N-phenyl-1,2,4,6,7,8-hexahydronaphthalen-2... 2 0
2,8-dimethyl-N-phenyl-1,2,3,4,4a,9b-hexahydropyrido[4,3-b]indo... 4 2
3,3,5,5,7,10c-hexamethyl-1,2,3,5,5a,6,10b,10c-octahydrocyclope... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00239113 CHEMBL1256192 Bioactive 1-(1-Naphthyl)piperazine hydrochloride
CFAMM00239147 CHEMBL2164329 Bioactive 1-[2-(2-methylphenyl)phenyl]piperazine
CFAMM00239131 CHEMBL2164332 Bioactive 1-[2-(4-fluorophenyl)phenyl]piperazine
CFAMM00239129 CHEMBL2164334 Bioactive 1-[2-(3,4-dimethylphenyl)phenyl]piperazine
CFAMM00239168 CHEMBL556759 Bioactive AGN-PC-07C0ZN
CFAMM00239137 DNC004498 Investigative Drug 1-Naphthalen-2-yl-piperazine
CFAMM00239110 DNC011082 Investigative Drug N1-(naphthalen-1-yl)ethane-1,2-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543