CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1453
Family Name cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 6-imidazol-1-yl-3,4-dihydro-1h-quinolin-2-one Family
No. of Seeds 2 No. of Other Members 30
Family Centroid CFAMM00239224 Functional Category Investigative Drug
Superfamily cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 6-imidazol-1-yl-3,4-dihydro-1h-quinolin-2-one Superfamily
Class Class 715

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Prothrombin Inhibitor Dabigatran Family 7 182
Telomerase protein component 1 Inhibitor GRN163L Family 5 29
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Thromboxane-A synthase Inhibitor CGS-13080 Family 3 19
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-aminobenzyl... 3 6
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Aromatase Inhibitor 2-(1h-imidazol-1-yl)-1-(4-nitrophenyl)etha... 2 29
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Cytochrome P450 11B1, mitochondrial and Cytochrome P450 11B2, ... 3 4
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Aromatase and Beta-lactamase inhibitor N-(3-Imidazol-1-yl-prop... 1 1
Nonstructural protein 1 and Lysine-specific demethylase 4E inh... 2 1
Thromboxane-A synthase inhibitor AGN-PC-00OGRA family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00239224 DNC004499 Investigative Drug 6-Imidazol-1-yl-3,4-dihydro-1H-quinolin-2-one
CFAMM00239214 DNC004509 Investigative Drug 6-(2-Imidazol-1-yl-vinyl)-1H-quinolin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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