CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1457
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 1B Ligand 1-(7-methoxy-naphthalen-2-yl)-piperazine Family
No. of Seeds 6 No. of Other Members 131
Family Centroid CFAMM00239398 Functional Category Investigative Drug with Natural Product
Superfamily Squalene monooxygenase Inhibitor Tolnaftate Superfamily
Class Class 615

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Opioid receptor ligand opiate Levorphanol Family 18 537
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Acetylcholinesterase Inhibitor Edrophonium Family 7 40
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Squalene monooxygenase Inhibitor Tolnaftate Family 1 4
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
Substance-P receptor Ligand Ezlopitant Family 10 207
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
D(3) dopamine receptor Ligand U-99194A Family 7 33
Dapoxetine family 3 40
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Voltage-dependent L-type calcium channel Ligand Sq32,910 Family 1 25
Histamine H3 receptor Ligand A-331440 Family 6 7
Multidrug resistance protein Inhibitor MM36 Family 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Coagulation factor VII and Coagulation factor X Inhibitor 4-(4... 2 12
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-aminonaphthalen-1-ol... 2 34
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(ethylamino)naphthal... 10 13
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Aromatase Inhibitor 2,3,4-trimethoxy-4'-amino-trans-stilbene F... 9 14
Aromatase Inhibitor 2,3-dimethoxy-4'-amino-trans-stilbene Family 5 12
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
Acetylcholinesterase Inhibitor 6-methyl-4-(4-phenylpiperazin-1... 6 622
Fatty-acid amide hydrolase 1 Inhibitor 4-nitrophenyl 4-benzylp... 5 35
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 6
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
Alpha-2A adrenergic receptor and 5-hydroxytryptamine receptor ... 7 10
D(4) dopamine receptor and D(2) dopamine receptor ligand 7-[[4... 1 23
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 8 0
Transient receptor potential cation channel subfamily V member... 3 15
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Sigma non-opioid intracellular receptor 1 ligand CHEMBL154452 ... 2 1
Neuropeptide S receptor and Survival motor neuron protein liga... 1 2
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 9
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
Sigma non-opioid intracellular receptor 1 ligand STK145388 family 1 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 1-(4-... 2 3
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 6-met... 2 6
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 2 3
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
5-hydroxytryptamine receptor 1A and D(4) dopamine receptor lig... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 0
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
Histamine H3 receptor ligand SureCN6071181 family 2 1
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 3
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
5-hydroxytryptamine receptor 7 ligand 1-(2-methoxyphenyl)-4-[2... 6 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 1
Somatostatin receptor type 1 and D(4) dopamine receptor ligand... 9 10
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 7 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Transporter and Sodium-dependent serotonin transporter inhibit... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
Substance-P receptor ligand CP 141938 family 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Melanin-concentrating hormone receptor 1 ligand SureCN6779516 ... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Histamine H3 receptor ligand SureCN3057839 family 1 0
Amyloid beta A4 protein inhibitor 2-(fluoranylmethyl)-3-[4-[(E... 1 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 1 7
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Protein-S-isoprenylcysteine O-methyltransferase inhibitor N-[2... 1 2
Amyloid beta A4 protein inhibitor 2-[(4-bromophenyl)methyl]-3-... 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand 1-(3-... 2 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor AGN-PC-04F7M... 1 3
2-[(1R,4aS,8aS)-4a-hydroxy-1-(4-methoxyphenyl)-2,3,4,5,6,7,8,8... 1 0
NP (e)-4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)vinyl)-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00239295 CHEMBL1923683 Bioactive 1-(4-aminophenyl)-6-methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonamide
CFAMM00239397 CHEMBL144445 Bioactive 1-[2-(7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)ethyl]-4-phenylpiperazine
CFAMM00239262 CHEMBL143728 Bioactive 1-[2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)ethyl]-4-phenylpiperazine
CFAMM00239296 CHEMBL1923682 Bioactive 1-(3-aminophenyl)-6-methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonamide
CFAMM00239398 DNC004503 Investigative Drug 1-(7-Methoxy-naphthalen-2-yl)-piperazine
CFAMM00239359 DNC009270 Investigative Drug (R)-11-Amino-2-methoxyaporphine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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