| Cousin Family Names | Seeds | Members |
|---|
| 5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... | 14 | 2769 |
| 5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... | 4 | 171 |
| Histamine H1 receptor ligand tricyclic antidepressant Loratadi... | 5 | 163 |
| CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Amrino... | 3 | 55 |
| Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... | 7 | 189 |
| HIV protease Inhibitor Saquinavir Family | 64 | 428 |
| Nicotinic acetylcholine receptor Ligand Nicotine Family | 14 | 686 |
| Reverse transcriptase Inhibitor Nevirapine Family | 23 | 640 |
| D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... | 22 | 170 |
| D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family | 5 | 74 |
| Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... | 26 | 1171 |
| 5-hydroxytryptamine receptor 3A Ligand Granisetron Family | 26 | 212 |
| Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family | 3 | 73 |
| Somatostatin receptor type 2 ligand octapeptide Octreotide Family | 27 | 172 |
| Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family | 9 | 243 |
| Thromboxane A2 receptor Ligand Ridogrel Family | 7 | 83 |
| Sodium channel protein type 5 subunit alpha Ligand Disopyramid... | 4 | 352 |
| HIV-1 protease Inhibitor Atazanavir Family | 16 | 58 |
| Solute carrier family 12 member 1 Inhibitor Torasemide Family | 13 | 75 |
| Gamma-aminobutyric acid A receptor Ligand Bromazepam Family | 2 | 60 |
| Histamine H1 receptor Ligand Pheniramine Family | 10 | 380 |
| Histamine H1 receptor Ligand Triprolidine Family | 19 | 316 |
| Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family | 8 | 328 |
| 26S proteasome Inhibitor Bortezomib Family | 7 | 65 |
| SUR2-type K(ATP) channel Ligand Nicorandil Family | 5 | 85 |
| Prothrombin Inhibitor Ximelegatran Family | 8 | 157 |
| Transient receptor potential cation channel subfamily V member... | 15 | 158 |
| Hepatocyte growth factor receptor Ligand Arq 197 Family | 10 | 400 |
| Transient receptor potential cation channel subfamily V member... | 16 | 295 |
| Glycogen synthase kinase-3 beta and Protein kinase C beta type... | 5 | 53 |
| Histone deacetylase 1 Inhibitor MS-275 Family | 4 | 41 |
| Glycogen phosphorylase, muscle form Inhibitor PSN357 Family | 3 | 253 |
| Neuromedin-K receptor Ligand SB222200 Family | 17 | 235 |
| Cholecystokinin receptor type A Ligand Tarazepide Family | 6 | 323 |
| Calcitonin gene-related peptide type 1 receptor Ligand Telcage... | 25 | 124 |
| Substance-P receptor Ligand GSK424887 Family | 8 | 184 |
| Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family | 13 | 179 |
| Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family | 5 | 154 |
| Mast/stem cell growth factor receptor Kit and Vascular endothe... | 4 | 47 |
| Potassium voltage-gated channel subfamily KQT member 1 Ligand ... | 13 | 242 |
| Coagulation factor X Inhibitor Otamixaban Family | 9 | 21 |
| Glutamate receptor AMPA subtype Ligand CX-516 Family | 9 | 24 |
| Gamma-aminobutyric acid receptor Ligand E-2007 Family | 7 | 118 |
| Growth hormone receptor Ligand EP-51216 Family | 34 | 390 |
| D(1B) dopamine receptor Ligand LE-300 Family | 65 | 452 |
| Histone deacetylase 1 Inhibitor Panobinostat Family | 5 | 93 |
| D(3) dopamine receptor Ligand SB-277011 Family | 13 | 178 |
| Protein kinase C alpha type and Protein kinase C beta type Inh... | 16 | 86 |
| Substance-P receptor Ligand TAK-637 Family | 18 | 63 |
| Histone deacetylase 1 Inhibitor Pyroxamide Family | 4 | 13 |
| Amg 423 family | 7 | 47 |
| Setipiprant family | 5 | 118 |
| ABC294640 family | 5 | 75 |
| TGF-beta receptor type-1 Ligand LY2157299 Family | 13 | 56 |
| CP-18770 family | 6 | 27 |
| JAK Inhibitor Momelotinib Family | 33 | 83 |
| Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family | 6 | 29 |
| Gastrin/cholecystokinin type B receptor Ligand PD136450 Family | 53 | 117 |
| C-C chemokine receptor type 3 Ligand YM-344031 Family | 19 | 106 |
| 5-hydroxytryptamine receptor 2A Ligand RP-68303 Family | 7 | 44 |
| Lethal factor Inhibitor GM6001 Family | 50 | 435 |
| XL-888 family | 16 | 85 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... | 4 | 34 |
| Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... | 4 | 25 |
| Class II cytokine receptor Ligand IL-10 Family | 7 | 45 |
| Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... | 14 | 162 |
| Cannabinoid receptor 2 Ligand JWH-167 Family | 25 | 168 |
| Somatostatin receptor type 2 Ligand L-054852 Family | 13 | 88 |
| 5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family | 14 | 21 |
| Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... | 12 | 70 |
| Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... | 31 | 66 |
| Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... | 2 | 8 |
| D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... | 6 | 48 |
| Aromatase Inhibitor Rogletimide Family | 1 | 2 |
| Substance-K receptor and Substance-P receptor Ligand L-732138 ... | 8 | 147 |
| Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... | 7 | 117 |
| Integrin beta-3 Inhibitor Elarofiban Family | 28 | 45 |
| D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... | 7 | 102 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... | 4 | 19 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... | 4 | 22 |
| Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... | 3 | 5 |
| Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... | 4 | 21 |
| 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... | 4 | 93 |
| Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... | 4 | 8 |
| Alpha-1A adrenergic receptor Ligand L-771688 Family | 8 | 14 |
| 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... | 19 | 103 |
| MO15-related protein kinase Pfmrk Inhibitor (e)-1-(4-nitro-phe... | 2 | 9 |
| Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... | 18 | 36 |
| Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... | 14 | 22 |
| DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... | 2 | 6 |
| Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... | 19 | 64 |
| Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... | 12 | 10 |
| Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family | 112 | 67 |
| Cholecystokinin receptor type A Ligand VL-0395 Family | 12 | 117 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 13 | 26 |
| Branched-chain-amino-acid aminotransferase, cytosolic Inhibito... | 1 | 2 |
| Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... | 24 | 50 |
| Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... | 6 | 24 |
| Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... | 2 | 4 |
| Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... | 3 | 4 |
| Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... | 28 | 47 |
| Transient receptor potential cation channel subfamily V member... | 6 | 23 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... | 37 | 1 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... | 8 | 1 |
| D(4) dopamine receptor Ligand ABT-670 Family | 4 | 14 |
| Microsomal triglyceride transfer protein large subunit Inhibit... | 5 | 9 |
| Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... | 5 | 12 |
| Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... | 11 | 26 |
| Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... | 7 | 7 |
| Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... | 20 | 18 |
| C-C chemokine receptor type 5 Ligand GT-1282 Family | 21 | 14 |
| Nitric oxide synthase, inducible and Nitric oxide synthase, br... | 4 | 6 |
| Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... | 10 | 26 |
| Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... | 8 | 4 |
| 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... | 4 | 33 |
| 5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... | 3 | 17 |
| Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... | 4 | 10 |
| Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... | 6 | 14 |
| Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... | 30 | 31 |
| Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... | 4 | 11 |
| Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... | 2 | 2 |
| Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... | 19 | 108 |
| Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... | 8 | 38 |
| Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... | 19 | 32 |
| Urotensin-2 receptor Ligand Palosuran Family | 4 | 4 |
| Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... | 2 | 4 |
| Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... | 11 | 46 |
| Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... | 94 | 23 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... | 6 | 10 |
| Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... | 2 | 11 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... | 3 | 29 |
| Glutamate receptor 1 Ligand Piriqualone Family | 8 | 67 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... | 3 | 27 |
| Endothelin B receptor Ligand IRL-2500 Family | 34 | 87 |
| Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... | 10 | 19 |
| Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... | 12 | 46 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 12 | 72 |
| Metabotropic glutamate receptor 5 Ligand 1-(3-(2-methylquinoli... | 2 | 12 |
| Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... | 6 | 10 |
| Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... | 3 | 1 |
| Vasopressin V2 receptor Ligand YM-35278 Family | 33 | 38 |
| Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... | 2 | 3 |
| Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... | 12 | 160 |
| Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... | 2 | 9 |
| Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... | 4 | 12 |
| Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... | 10 | 14 |
| Histone deacetylase Inhibitor ST-5732 Family | 8 | 6 |
| Protein kinase C alpha type Inhibitor Dequalinium Analogue Family | 1 | 10 |
| Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... | 42 | 7 |
| Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... | 62 | 27 |
| Choline kinase alpha Inhibitor Bisquinolinium Derivative Family | 10 | 7 |
| Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Cycl... | 7 | 6 |
| Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... | 1 | 0 |
| Pol polyprotein inhibitor AC1LAD48 family | 19 | 5 |
| Substance-P receptor ligand AGN-PC-01ZIXQ family | 13 | 42 |
| Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... | 3 | 5 |
| Transient receptor potential cation channel subfamily V member... | 3 | 1 |
| Pol polyprotein inhibitor penicillin deriv. 40 family | 2 | 4 |
| RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... | 3 | 7 |
| Rho-associated protein kinase 2 and cAMP-dependent protein kin... | 2 | 7 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 s... | 17 | 14 |
| Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... | 1 | 13 |
| Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4... | 4 | 0 |
| Histamine H3 receptor and Potassium voltage-gated channel subf... | 1 | 3 |
| Prolyl endopeptidase inhibitor [(2S,3aS,7aS)-2-(pyrrole-1-carb... | 2 | 0 |
| Melanocortin receptor 4 and Potassium voltage-gated channel su... | 2 | 12 |
| Epidermal growth factor receptor ligand AGN-PC-07Q1HU family | 4 | 17 |
| Histamine H3 receptor and Potassium voltage-gated channel subf... | 2 | 2 |
| Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... | 2 | 4 |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... | 1 | 0 |
| Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... | 6 | 2 |
| Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... | 5 | 0 |
| Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... | 7 | 58 |
| Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... | 17 | 28 |
| Gastrin/cholecystokinin type B receptor and Cholecystokinin re... | 14 | 8 |
| Cathepsin L1 inhibitor Bio2_000267 family | 9 | 1 |
| Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... | 1 | 0 |
| Vascular endothelial growth factor receptor 2 and Receptor-typ... | 7 | 4 |
| Neuropeptide Y receptor type 5 ligand 2-[4-(benzenesulfonamido... | 2 | 27 |
| Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family | 2 | 6 |
| Survival motor neuron protein and Beta-lactamase inhibitor CHE... | 1 | 0 |
| Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... | 2 | 0 |
| Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family | 13 | 8 |
| Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... | 6 | 9 |
| Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... | 16 | 9 |
| Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... | 15 | 5 |
| Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... | 4 | 3 |
| Sodium-dependent serotonin transporter and Sodium-dependent do... | 10 | 2 |
| MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... | 6 | 0 |
| Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... | 2 | 14 |
| 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... | 11 | 20 |
| Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... | 2 | 3 |
| MAP kinase-activated protein kinase 2 and Mitogen-activated pr... | 5 | 2 |
| Histamine H3 receptor ligand AGN-PC-04YWRD family | 5 | 13 |
| 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... | 13 | 1 |
| Cathepsin K inhibitor SureCN2155973 family | 3 | 1 |
| Cruzipain and Cathepsin F inhibitor SureCN12999199 family | 2 | 1 |
| Cellular tumor antigen p53 inhibitor CHEMBL1418224 family | 1 | 62 |
| 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... | 4 | 0 |
| Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... | 3 | 0 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... | 1 | 1 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 s... | 2 | 1 |
| Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... | 1 | 36 |
| C-C chemokine receptor type 5 ligand AC1LA259 family | 1 | 1 |
| Gastrin/cholecystokinin type B receptor and Cholecystokinin re... | 2 | 0 |
| 5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... | 2 | 91 |
| Thyroid hormone receptor beta and Microtubule-associated prote... | 1 | 8 |
| 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... | 3 | 8 |
| Disintegrin and metalloproteinase domain-containing protein 17... | 4 | 0 |
| Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... | 3 | 2 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... | 2 | 1 |
| Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... | 2 | 5 |
| Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... | 1 | 7 |
| Mitogen-activated protein kinase 1 and Nonstructural protein 1... | 1 | 33 |
| Survival motor neuron protein and Menin inhibitor CHEMBL151109... | 1 | 11 |
| D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... | 5 | 8 |
| Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... | 2 | 34 |
| 72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... | 2 | 4 |
| Peptide deformylase inhibitor (2R)-N-[(2S)-3,3-dimethyl-1-oxo-... | 2 | 1 |
| Platelet-activating factor receptor ligand YM-461 family | 1 | 11 |
| Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... | 2 | 41 |
| Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... | 4 | 4 |
| 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 2 | 2 |
| Metabotropic glutamate receptor 2 and Metabotropic glutamate r... | 5 | 3 |
| Metabotropic glutamate receptor 2 ligand AGN-PC-00A1HD family | 2 | 0 |
| 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 5 | 1 |
| 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 3 | 1 |
| Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... | 4 | 2 |
| Dipeptidyl peptidase 4 inhibitor (2S)-1-[2-[5-(aminomethyl)-2-... | 4 | 4 |
| Dipeptidyl peptidase 4 inhibitor SureCN3389584 family | 2 | 2 |
| Acetylcholinesterase inhibitor CHEMBL1651131 family | 6 | 9 |
| Acetylcholinesterase inhibitor CHEMBL1651140 family | 4 | 4 |
| Translocator protein inhibitor AGN-PC-08WI0V family | 1 | 0 |
| Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family | 4 | 3 |
| Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family | 3 | 3 |
| Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family | 5 | 8 |
| Prothrombin inhibitor AGN-PC-09QKE4 family | 1 | 0 |
| Substance-K receptor ligand N-[1-[[(2S)-1-[[1-(oxan-4-ylmethyl... | 3 | 0 |
| Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... | 2 | 0 |
| Prostaglandin E synthase inhibitor AGN-PC-09QHBK family | 3 | 1 |
| Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... | 5 | 1 |
| Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... | 4 | 6 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... | 3 | 2 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... | 18 | 3 |
| Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... | 2 | 2 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... | 5 | 2 |
| Substance-P receptor and Neuromedin-K receptor ligand SureCN88... | 4 | 14 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 3 | 2 |
| D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... | 4 | 1 |
| Hepatocyte growth factor receptor ligand AGN-PC-08XYH0 family | 8 | 4 |
| Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family | 2 | 12 |
| Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 1 | 0 |
| Histamine H3 receptor ligand SureCN1857507 family | 1 | 4 |
| Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... | 2 | 2 |
| Renin inhibitor (3R,4S)-N-cyclopropyl-N-[[2-(3-methoxypropyl)q... | 2 | 0 |
| Renin and Potassium voltage-gated channel subfamily H member 2... | 9 | 2 |
| C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... | 5 | 0 |
| Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... | 3 | 4 |
| Beta-secretase 1 inhibitor 3-[2-amino-6-(2-methylphenyl)quinol... | 5 | 2 |
| Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... | 2 | 1 |
| Sodium-dependent serotonin transporter and 5-hydroxytryptamine... | 2 | 1 |
| CGMP-dependent protein kinase inhibitor AGN-PC-075XII family | 25 | 7 |
| Renin and Potassium voltage-gated channel subfamily H member 2... | 13 | 11 |
| 5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... | 18 | 5 |
| Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... | 7 | 0 |
| Neuronal acetylcholine receptor subunit alpha-7 ligand 1-(4-me... | 1 | 0 |
| Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... | 8 | 5 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 5 | 4 |
| Delta-type opioid receptor and Potassium voltage-gated channel... | 2 | 0 |
| Translocator protein inhibitor N,N-diethyl-11-(2-fluoroethyl)-... | 14 | 9 |
| Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... | 3 | 8 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... | 14 | 1 |
| C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... | 3 | 2 |
| Mast/stem cell growth factor receptor Kit and Mitogen-activate... | 4 | 2 |
| Macrophage colony-stimulating factor 1 receptor and Vascular e... | 2 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 3 | 0 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... | 5 | 5 |
| Mitogen-activated protein kinase 14 and Mitogen-activated prot... | 1 | 1 |
| Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... | 8 | 10 |
| Melanin-concentrating hormone receptor 1 and Melanin-concentra... | 3 | 1 |
| 5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... | 2 | 0 |
| Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... | 7 | 6 |
| Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... | 3 | 5 |
| Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... | 17 | 1 |
| Mitogen-activated protein kinase 10 and Mitogen-activated prot... | 8 | 5 |
| Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... | 5 | 5 |
| Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... | 1 | 0 |
| Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... | 2 | 0 |
| Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... | 1 | 7 |
| High affinity nerve growth factor receptor and BDNF/NT-3 growt... | 4 | 3 |
| Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... | 20 | 2 |
| Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... | 6 | 4 |
| Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... | 4 | 3 |
| Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... | 3 | 1 |
| Substance-P receptor ligand SureCN7796965 family | 9 | 1 |
| Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... | 5 | 8 |
| Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-isoquinolin-1-y... | 3 | 2 |
| Prothrombin and Tissue-type plasminogen activator inhibitor 2-... | 4 | 5 |
| Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... | 1 | 0 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... | 2 | 3 |
| Histamine H3 receptor ligand (4-propan-2-yl-1,4-diazepan-1-yl)... | 1 | 0 |
| Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... | 2 | 14 |
| Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... | 2 | 3 |
| Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... | 10 | 7 |
| 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... | 1 | 1 |
| Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... | 2 | 1 |
| Neuromedin-K receptor and Potassium voltage-gated channel subf... | 13 | 2 |
| Mitogen-activated protein kinase 13 and Mitogen-activated prot... | 3 | 2 |
| Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... | 6 | 8 |
| Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... | 5 | 0 |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... | 6 | 0 |
| Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... | 3 | 2 |
| RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... | 11 | 4 |
| Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... | 22 | 3 |
| Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... | 3 | 1 |
| Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... | 1 | 0 |
| Disintegrin and metalloproteinase domain-containing protein 17... | 7 | 9 |
| Disintegrin and metalloproteinase domain-containing protein 17... | 13 | 3 |
| Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... | 4 | 12 |
| Motilin receptor ligand SureCN2768052 family | 3 | 0 |
| C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... | 3 | 2 |
| Prostaglandin D2 receptor 2 ligand 2-[3-[(E)-2-cyano-3-(N-meth... | 9 | 9 |
| Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... | 12 | 4 |
| C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... | 2 | 1 |
| Metabotropic glutamate receptor 5 ligand AGN-PC-09SALK family | 2 | 15 |
| Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... | 2 | 8 |
| Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... | 2 | 0 |
| C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... | 16 | 4 |
| Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... | 7 | 0 |
| Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... | 2 | 0 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... | 2 | 1 |
| Cathepsin K inhibitor AGN-PC-046RTV family | 4 | 1 |
| Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... | 2 | 14 |
| Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... | 3 | 0 |
| Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... | 2 | 2 |
| Somatostatin receptor type 1 and Somatostatin receptor type 2 ... | 2 | 18 |
| C-C chemokine receptor type 2 ligand SureCN5947024 family | 11 | 0 |
| CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... | 6 | 1 |
| C-C chemokine receptor type 2 and Potassium voltage-gated chan... | 1 | 2 |
| Prothrombin inhibitor N-[(6-amino-2-methylpyridin-3-yl)methyl]... | 2 | 0 |
| Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... | 2 | 1 |
| Cholinesterase and Acetylcholinesterase inhibitor [2,2-dimethy... | 2 | 0 |
| CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... | 2 | 0 |
| Substance-P receptor ligand AGN-PC-004REJ family | 3 | 0 |
| Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... | 4 | 1 |
| Bombesin receptor subtype-3 ligand SureCN13887096 family | 3 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... | 2 | 2 |
| 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... | 2 | 2 |
| Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... | 2 | 1 |
| Neuromedin-B receptor and Gastrin-releasing peptide receptor l... | 6 | 4 |
| Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... | 3 | 1 |
| Neuromedin-B receptor and Gastrin-releasing peptide receptor l... | 2 | 0 |
| Platelet-activating factor receptor ligand SureCN9853140 family | 3 | 3 |
| Substance-P receptor and Substance-K receptor ligand N-methyl-... | 2 | 2 |
| Histone deacetylase 1 inhibitor AGN-PC-0456JP family | 1 | 0 |
| Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... | 2 | 1 |
| Platelet-activating factor receptor ligand SureCN9852997 family | 1 | 1 |
| Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... | 5 | 2 |
| KiSS-1 receptor ligand SureCN5132924 family | 2 | 4 |
| Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... | 2 | 0 |
| Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... | 2 | 0 |
| Sodium-dependent serotonin transporter and D(2) dopamine recep... | 1 | 0 |
| Somatostatin receptor type 4 and Somatostatin receptor type 5 ... | 3 | 4 |
| 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 5 | 0 |
| Cytochrome P450 2C9 inhibitor AGN-PC-04XDND family | 1 | 3 |
| Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... | 4 | 17 |
| Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... | 4 | 2 |
| 5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... | 3 | 4 |
| P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... | 3 | 3 |
| Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... | 9 | 0 |
| 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... | 1 | 0 |
| D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... | 2 | 1 |
| P2X purinoceptor 7 inhibitor N'-quinolin-5-yladamantane-1-carb... | 2 | 9 |
| Macrophage colony-stimulating factor 1 receptor ligand SureCN1... | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 1 | 1 |
| Melanin-concentrating hormone receptor 1 ligand SureCN4917950 ... | 3 | 5 |
| 5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family | 1 | 0 |
| P2Y purinoceptor 12 inhibitor (4S)-4-[(4,6-diphenylpyridine-2-... | 1 | 0 |
| Interstitial collagenase and Stromelysin-1 inhibitor CHEMBL887... | 1 | 0 |
| Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... | 1 | 2 |
| Rho-associated protein kinase 2 and Rho-associated protein kin... | 1 | 0 |
| D(4) dopamine receptor ligand SureCN4006627 family | 1 | 0 |
| Methionine aminopeptidase 1 inhibitor ethyl 4-[4-(2-pyridin-2-... | 2 | 3 |
| Acetylcholinesterase inhibitor CHEMBL267591 family | 5 | 0 |
| Interstitial collagenase and Matrix metalloproteinase-9 inhibi... | 1 | 5 |
| Histamine H3 receptor ligand Conessine analogue, 12e family | 1 | 6 |
| NADPH oxidase 4 inhibitor AGN-PC-09M5SP family | 1 | 1 |
| Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... | 1 | 0 |
| Proto-oncogene Wnt-3 inhibitor CHEMBL563202 family | 2 | 0 |
| N-[2-(1-oxidopyridin-1-ium-2-yl)ethyl]-N-phenylacetamide NP 2-... | 1 | 2 |
| Putative NP ZINC03999850 Family | 4 | 0 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
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How to cite our database |
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C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
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