CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1460
Family Name Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-pyridin-3-yl-2,3-dihydro-1h-inden-1-one Family
No. of Seeds 3 No. of Other Members 5
Family Centroid CFAMM00239490 Functional Category Investigative Drug with Natural Product
Superfamily Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-pyridin-3-yl-2,3-dihydro-1h-inden-1-one Superfamily
Class Class 2124

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Thromboxane A2 receptor Ligand Ridogrel Family 7 83
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Histamine H1 receptor Ligand (s)-(+)-dimethindene Maleate Family 6 12
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Neuromedin-K receptor Ligand SB222200 Family 17 235
Proteinase-activated receptor 1 Ligand SCH-530348 Family 20 215
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
ABC294640 family 5 75
Pixantrone family 2 3
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 5 23
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
MO15-related protein kinase Pfmrk Inhibitor (e)-1-(4-nitro-phe... 2 9
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Cannabinoid receptor 2 Ligand JWH-249 Family 7 13
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Metabotropic glutamate receptor 1 Ligand (e)-4,4-dimethyl-1-qu... 2 2
Aldose reductase Inhibitor 3-(3-benzoyl-1h-pyrrol-1-yl)propano... 3 7
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Metabotropic glutamate receptor 1 ligand GTPL6334 family 6 4
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 12
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Cathepsin K inhibitor AGN-PC-046RTV family 4 1
Progesterone receptor ligand (8S,11R,13S,14S,16R,17S)-17-(cycl... 11 0
Thromboxane-A synthase inhibitor 7-[(2S,3R)-3-pyridin-3-yl-2-b... 1 1
Metabotropic glutamate receptor 1 ligand AGN-PC-07CPMZ family 1 0
Amine oxidase [flavin-containing] A inhibitor CHEMBL1917530 fa... 1 0
Histamine H3 receptor ligand Conessine analogue, 12e family 1 6
Prelamin-A/C and Excitatory amino acid transporter 1 inhibitor... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 1
Pyridines and Derivatives Metabolite (R)-Boschniakine Family 1 0
Pyridines and Derivatives Metabolite Rotundine A Family 1 0
Naphthyridines Metabolite 3-Acetyl-2,7-naphthyridine Family 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00239484 DNC004512 Investigative Drug MR-20496
CFAMM00239490 DNC009637 Investigative Drug 5-Pyridin-3-yl-2,3-dihydro-1H-inden-1-one
CFAMM00239489 DNC009636 Investigative Drug 6-Pyridin-3-yl-3,4-dihydronaphthalen-2(1H)-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27254 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543