CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID1483
Family Name Neuromedin-K receptor Ligand PD-157672 Family
No. of Seeds 9 No. of Other Members 37
Family Centroid CFAMM00240055 Functional Category Investigative Drug with Natural Product
Superfamily Prothrombin and Neuromedin-K receptor Binder Superfamily
Class Class 1362

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Vasopressin V1a receptor Ligand Felypressin Family 12 820
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Sodium channel protein type 5 subunit alpha Ligand Mephenytoin... 5 51
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme inhibitor Phosphonate-containing... 7 41
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
DNA Binder Procarbazine Family 8 358
Noradrenergic re-uptake Inhibitor Milnacipran Family 7 51
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
20S proteasome Inhibitor Carfilzomib Family 5 17
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Cathepsin K Inhibitor Odanacatib Family 33 84
Dopamine reuptake Inhibitor Amineptine Family 2 5
Motilin receptor Ligand GSK962040 Family 30 457
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 2 18
Substance-P receptor Ligand Vestipitant Family 14 137
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Bavisant family 9 65
Neuropeptide Y receptor type 1 Ligand BIBO3304 Family 4 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
72 kDa type IV collagenase Inhibitor Batimastat Family 6 52
Flovagatran family 12 546
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Renin Inhibitor CP-80794 Family 16 112
Prothrombin Inhibitor Efegatran Family 9 47
Neutrophil elastase Inhibitor FK-706 Family 8 85
Neprilysin Inhibitor Thiorphan Family 41 68
Prothrombin Inhibitor LB30812 Family 12 36
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Prothrombin Inhibitor Ppack Family 5 4
Neuromedin-K receptor Ligand Senktide Family 15 22
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Prothrombin Inhibitor D-leucyl-n-(4-carbamimidoylbenzyl)-l-pro... 13 44
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cruzipain Inhibitor WRR-204 Family 18 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 3 12
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-lle-agly-ile-v... 17 7
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-nal-agly-ile-v... 3 2
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Nociceptin receptor Ligand Fggftgcrkscrk Family 10 0
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 1 3
Cathepsin B and Cathepsin K Inhibitor (s)-1-benzylcyclopentyl ... 11 5
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-valp... 8 5
Cathepsin B and Cathepsin S Inhibitor Cbz-ile-leu-ala-leuvsme ... 12 14
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Chymase Inhibitor Chymostatin Family 2 3
Cruzipain Inhibitor K-777 Family 3 8
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Cytosolic phospholipase A2 Inhibitor Methyl 2-(2-oxo-8-phenylo... 2 3
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-154957 Family 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Receptor-type tyrosine-protein phosphatase C Ligand Asp-brpmp-... 2 0
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Aminopeptidase N Inhibitor 2-amino-n1-benzyl-n3-hydroxymalonam... 3 4
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(3-... 1 7
Renin inhibitor (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-[[... 12 1
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Prothrombin and Coagulation factor X inhibitor AGN-PC-074UE2 f... 1 0
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(1-me... 3 8
Substance-K receptor ligand (4S)-4-amino-1-[4-(oxan-4-ylmethyl... 1 2
Cathepsin K inhibitor [(3S)-4,4-dimethyl-2-oxo-1-(2-phenylethy... 7 9
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 2 0
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-3-[... 13 17
Renin and Cathepsin D inhibitor (2S)-N-[(2S,3R,4S)-1-cyclohexy... 13 2
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Aminopeptidase N and Neprilysin inhibitor (2S)-2-[[(2S)-2-[[[(... 1 0
Carboxypeptidase B and Carboxypeptidase B2 inhibitor (2S)-7-am... 3 9
Renin inhibitor tert-butyl N-[1-[[(3S,6S,7R)-6-(cyclohexylmeth... 14 1
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
NS3 and Non-structural protein 4A inhibitor (4S)-4-[[(2S)-3-ca... 1 1
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 3 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 5 11
Growth hormone secretagogue receptor type 1 ligand SureCN63170... 1 1
Caspase-1 inhibitor (3S)-3-[[(2S)-4-(2-naphthalen-1-ylethylami... 1 0
Baculoviral IAP repeat-containing protein 2 and Baculoviral IA... 2 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 5 3
Prothrombin inhibitor SureCN7341151 family 6 7
Oxytocin receptor and Vasopressin V1a receptor ligand L 365209... 6 1
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 3
Survival motor neuron protein inhibitor CHEMBL1323700 family 1 4
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 8
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 3 1
Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-nap... 6 26
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Renin inhibitor [(2R)-1-[[(2S,3S,5R)-6-(butylamino)-1-cyclohex... 5 4
Disintegrin and metalloproteinase domain-containing protein 17... 6 5
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Neprilysin inhibitor SureCN489232 family 3 9
Cathepsin S inhibitor SureCN7062841 family 7 7
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Peptide deformylase inhibitor (2R)-N-[(2S)-1-(4-fluorophenyl)-... 4 0
Neprilysin inhibitor AGN-PC-047EOK family 7 4
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 0
Cathepsin K inhibitor [(3R)-4,4-dimethyl-1-phenylpentan-3-yl] ... 7 7
Cannabinoid receptor 2 ligand AGN-PC-087MPO family 7 21
Cathepsin K and Cathepsin S inhibitor 1-benzyl-3-[(2S)-1-[[cya... 1 0
Neutrophil elastase inhibitor benzyl N-[(2S)-1-[(2S)-2-[[(3S)-... 4 0
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 6 1
Growth factor receptor-bound protein 2 ligand 2-[(9S,10S,11E,1... 5 14
Neuromedin-K receptor ligand SureCN2477089 family 2 4
Chymase and Chymotrypsinogen A inhibitor tert-butyl N-[(2S)-1-... 2 7
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 3 4
Tryptase alpha/beta-1 inhibitor methyl 3-[3-(aminomethyl)pheny... 1 3
Coagulation factor X inhibitor (6S,8aS)-N-[(1-carbamimidoylpip... 6 0
Growth factor receptor-bound protein 2 ligand [4-[[(2S,5S,9S,1... 2 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2S... 16 24
Neutrophil collagenase and Collagenase 3 inhibitor n-[[2-methy... 1 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
Dipeptidyl peptidase 4 inhibitor (3R)-4-[(3R)-3-amino-4-(2,4,5... 6 6
Dipeptidyl peptidase 4 inhibitor (3S)-4-[(3R)-3-amino-4-(2,4,5... 1 1
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Carbonic anhydrase 12 and Carbonic anhydrase 2 inhibitor AGN-P... 5 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 16 1
Pol polyprotein inhibitor AC1LADQG family 7 1
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand (2R)-3-(4-chlorophenyl)-2-[[2-... 6 2
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-(... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 1 1
Dipeptidyl peptidase 4 inhibitor (2S,3S)-3-amino-2-[4-(4-fluor... 1 0
Cathepsin K and Cathepsin S inhibitor (2,2,4-trimethyl-3-bicyc... 1 0
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Sigma non-opioid intracellular receptor 1 ligand 2-(3-bromophe... 5 1
Lysine-specific histone demethylase 1A and Amine oxidase [flav... 2 1
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Pol polyprotein inhibitor MDL 74538 family 11 1
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Dipeptidyl peptidase 4 inhibitor SureCN2709139 family 5 7
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Cathepsin K and Cathepsin S inhibitor SureCN6197793 family 1 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Peptide deformylase inhibitor (2S)-N-benzoyl-1-[(2R)-2-(cyclop... 2 2
NS3 and Neutrophil elastase inhibitor (2S)-3-[(2S)-2-(tert-but... 1 3
NS3 inhibitor SureCN14450642 family 4 7
NS3 inhibitor 2-methylpropyl N-[(2S)-1-[(3aR,4S,6aR)-4-[[1-[[2... 1 0
Dipeptidyl peptidase 4 inhibitor (2S,3S)-3-amino-4-[(3S)-3-flu... 1 5
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 3 0
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 4 0
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
Menin inhibitor CHEMBL2314816 family 2 6
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Cationic trypsin and Prothrombin inhibitor (2S)-N-[(2S)-5-(dia... 2 0
Renin inhibitor AGN-PC-076HPD family 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 5 3
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 15 0
Cationic trypsin and Prothrombin inhibitor (3S,6S)-6-amino-6-b... 4 2
Renin and Cathepsin D inhibitor ethyl (4S)-5-cyclohexyl-2,2-di... 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Type-2 angiotensin II receptor ligand SureCN3515167 family 2 0
Neprilysin inhibitor SureCN7437961 family 2 6
Pol polyprotein inhibitor AC1L9R8I family 1 0
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Protease inhibitor AC1O54RX family 2 4
Pol polyprotein inhibitor AC1LA4ZN family 1 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 10 0
Renin inhibitor 2-methylpropyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl... 14 0
Coagulation factor X inhibitor ethyl 2-[[(3S)-3-[[2-[[(2R)-2-(... 4 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3R)-1-cyclohexyl-3-h... 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
Tryptase alpha/beta-1 and Tryptase delta inhibitor [4-[[2-[[4-... 2 1
Collagenase 3 and Interstitial collagenase inhibitor (4-benzyl... 2 0
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Pol polyprotein inhibitor AC1LA3C0 family 2 18
Prothrombin inhibitor methyl (3S)-3-[[(6S,8aS)-2-benzylsulfony... 5 1
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 0
Pol polyprotein inhibitor Diol-Based HIV-1 protease inhibitor ... 1 0
Pepsin A and Renin inhibitor N-[(3R)-1-[[(1S)-1-hydroxy-3-[[(2... 1 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor Su... 1 1
Renin inhibitor N-[(2S)-1-[[(2R)-1-[[(2S)-3-cyclohexyl-1-dimet... 3 1
Chymase and Chymotrypsinogen B inhibitor AGN-PC-075LTI family 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Sigma non-opioid intracellular receptor 1 ligand tert-butyl N-... 1 9
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 0
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 13
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (3R)-3-... 3 2
Prothrombin inhibitor [(1R)-4-carbamimidoylsulfanyl-1-[[2-[met... 1 0
Angiotensin-converting enzyme inhibitor SureCN7263641 family 2 11
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
C-C chemokine receptor type 5 ligand benzyl N-[1-[(4S)-4-(cycl... 1 0
Calpain-1 catalytic subunit inhibitor Peptidyl alpha-Ketoacid,... 1 0
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
Histamine H3 receptor ligand Conessine analogue, 13e family 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 9 0
Receptor tyrosine-protein kinase erbB-2 and Disintegrin and me... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 6
Prothrombin inhibitor 1-(2-amino-3,3-diphenylpropanoyl)-N-[(3-... 1 1
Interstitial collagenase and 72 kDa type IV collagenase inhibi... 1 1
Neutrophil collagenase and Macrophage metalloelastase inhibito... 1 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Pol polyprotein and Pepsin A inhibitor cgp 53820 family 1 1
Pol polyprotein inhibitor methyl (2S)-2-[[(2R,4S,5S)-2-benzyl-... 1 1
Ribonucleoside-diphosphate reductase large subunit and Ribonuc... 1 0
Trypsin-1 and Prothrombin inhibitor tert-butyl N-[2-[(2S)-2-[[... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Glucose-dependent insulinotropic receptor ligand (1-methylcycl... 4 3
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Histone deacetylase 8 and Histone deacetylase 1 inhibitor tert... 1 0
Papain and Cathepsin S inhibitor dipeptide-derived nitrile, 28... 1 2
Beta-secretase 1 inhibitor (2R)-4-amino-2-[[(2S)-2-[[(2S)-2-[[... 2 1
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 2
Cathepsin L1 inhibitor (2R)-2-[[3-benzylsulfanyl-2-[[2-(4-phen... 1 0
Matrix metalloproteinase-9 and Metalloproteinase inhibitor 3 i... 6 4
NS3 inhibitor 6-[[(2S)-1-[[(2S)-1-[(2S)-2-[[1-(cyclopropylamin... 2 0
Bifunctional epoxide hydrolase 2 inhibitor (2S)-3-(3a,7a-dihyd... 1 0
Tyrosine-protein kinase Lck inhibitor 1-[2-[bis[3-[bis[3-[bis(... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 5
Genome polyprotein inhibitor Benzoyl-KKR-H family 1 1
Prolyl endopeptidase inhibitor 3eq9 family 1 0
Acetylcholinesterase and Cholinesterase inhibitor hexyl (2S)-5... 1 7
4'-phosphopantetheinyl transferase ffp and Beta-lactamase inhi... 1 0
DNA polymerase beta and Muscleblind-like protein 1 inhibitor C... 1 0
Putative fructose-1,6-bisphosphate aldolase and Nuclear recept... 1 6
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (3... 2 0
Pol polyprotein inhibitor methyl (2S)-2-[[(2S)-2-[[(2S)-2-[5-[... 1 2
Tubulin beta-1 chain inhibitor SureCN6672529 family 1 0
Transcriptional activator protein LuxR inhibitor 3-(3-iodophen... 8 2
carboxamide NP (s)-n1-(1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)... 2 0
NP Tert-butyl ((s)-1-oxo-1-((1r,5s)-8-oxo-5,6-dihydro-1h-1,5-m... 1 0
NP (2s)-2-(2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)... 2 0
Putative NP ZINC08790318 Family 1 0
4-[[[1-[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-pheny... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00240053 CHEMBL131779 Bioactive 2-[(2,2-diphenylacetyl)amino]-N-[1-(ethylamino)-1,2-dioxopentan-3-yl]-4-methylpentanamide
CFAMM00240067 CHEMBL67695 Bioactive tert-butyl N-[(2S)-1-[[(2S)-1-[[1-cyclohexyl-4,4-difluoro-5-(3-methylbutanoylamino)-3-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
CFAMM00240050 CHEMBL291091 Bioactive tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2,2-difluoro-6-methyl-1,3-dioxoheptan-4-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
CFAMM00240081 CHEMBL2032447 Bioactive (2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanamide
CFAMM00240088 CHEMBL63279 Bioactive ethyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
CFAMM00240062 CHEMBL75180 Bioactive [(2R)-3-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-benzyl-3-oxopropyl]-[(1S)-1-[(2-methylpropan-2-yl)oxycarbonylamino]-2-phenylethyl]phosphinic acid
CFAMM00240061 CHEMBL2028992 Bioactive [4-(diaminomethylideneamino)-1-[[2-[[(2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]amino]acetyl]amino]butyl]boronic acid
CFAMM00240093 CHEMBL74041 Bioactive [3-[[(2S)-1-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2-benzyl-3-oxopropyl]-[(1S)-1-[[(2S)-3-methyl-2-[[(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]amino]butanoyl]amino]-2-phenylethyl]phosphinic acid
CFAMM00240055 DNC004607 Investigative Drug PD-157672

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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