CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1487
Family Name Prothrombin Inhibitor RWJ-50353 Family
No. of Seeds 11 No. of Other Members 95
Family Centroid CFAMM00240211 Functional Category Investigative Drug
Superfamily Prothrombin and Mu-type opioid receptor Binder Superfamily
Class Class 2130

Cousin Family NamesSeedsMembers
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-me... 2 45
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 4 3
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-2-(1,3-b... 1 1
Histone deacetylase 1 and Histone deacetylase 2 inhibitor AGN-... 2 5
Prothrombin inhibitor (2S)-N-[(4-carbamimidoyl-1,3-thiazol-2-y... 3 2
Protease and Capsid scaffolding protein inhibitor AC1LAC7K family 2 5
Mitogen-activated protein kinase 1 and Retinal dehydrogenase 1... 1 5
Coagulation factor X and Prothrombin inhibitor (2S)-2-(benzyls... 4 4
Coagulation factor X and Prothrombin inhibitor AGN-PC-0754DR f... 2 2
Coagulation factor X and Prothrombin inhibitor N-[5-(diaminome... 2 0
Trypsin-1 and Prothrombin inhibitor (6S,8aS)-N-[(2S)-5-(diamin... 1 1
Prothrombin inhibitor (3R,6S,8aS)-N-[5-(diaminomethylideneamin... 2 3
Prothrombin and Cationic trypsin inhibitor 2-ketobenzothiazole... 3 3
Prothrombin inhibitor methyl 2-[(2S)-5-(diaminomethylideneamin... 4 2
Sodium-dependent serotonin transporter and D(4) dopamine recep... 2 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 3
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(4-phenyl-1,3-t... 3 4
Suppressor of tumorigenicity 14 protein and Serine protease he... 6 0
Cathepsin K and Cathepsin L1 inhibitor (2R)-N-(cyanomethyl)-4-... 2 1
Histone deacetylase 1 inhibitor N',N'-bis[2-(1,3-benzothiazol-... 2 0
Prothrombin and Cationic trypsin inhibitor 2-ketobenzothiazole... 1 0
Cationic trypsin and Prothrombin inhibitor (2S)-N-[1-(1,3-benz... 1 0
Granzyme B inhibitor CHEMBL436855 family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00240254 CHEMBL421643 Bioactive (2S)-2-acetamido-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide;2,2,2-trifluoroacetic acid
CFAMM00240185 CHEMBL127773 Bioactive (2S)-1-acetyl-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-oxopyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
CFAMM00240218 CHEMBL127185 Bioactive (2R)-1-acetyl-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
CFAMM00240210 CHEMBL124809 Bioactive methyl (2S)-2-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-sulfonate;2,2,2-trifluoroacetic acid
CFAMM00240224 CHEMBL421466 Bioactive (2S)-1-acetyl-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2,5-dihydropyrrole-2-carboxamide;2,2,2-trifluoroacetic acid
CFAMM00240209 CHEMBL339703 Bioactive (2S)-1-acetyl-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]azetidine-2-carboxamide;2,2,2-trifluoroacetic acid
CFAMM00240223 CHEMBL340098 Bioactive 2-acetamido-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]acetamide;2,2,2-trifluoroacetic acid
CFAMM00240244 CHEMBL175497 Bioactive 2-ketobenzothiazole 20
CFAMM00240173 CHEMBL340183 Bioactive (2S)-1-acetyl-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
CFAMM00240211 DNC004622 Investigative Drug RWJ-50353
CFAMM00240220 DNC014733 Investigative Drug RWJ-56423

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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