CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1488
Family Name Estradiol 17-beta-dehydrogenase 1 Inhibitor N-n-diethyl Estradiol-16-methyl Carboxamide Family
No. of Seeds 6 No. of Other Members 16
Family Centroid CFAMM00240266 Functional Category Investigative Drug
Superfamily Estradiol 17-beta-dehydrogenase 1 Binder Superfamily 2
Class Class 638

Cousin Family NamesSeedsMembers
Estrogen receptor beta Ligand Conjugated Estrogens Family 12 210
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-ethyl Estrone-16... 3 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-isopropyl Estrad... 3 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Sigma non-opioid intracellular receptor 1 and Mu-type opioid r... 7 5
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 1 1
5-hydroxytryptamine receptor 1A ligand 8-[4-[[(2S)-5-fluoro-8-... 4 3
Estrogen receptor beta and Estrogen receptor ligand (E)-3-[4-[... 2 0


External ID

Functional Category

Molecule Name

CFAMM00240263 DNC004624 Investigative Drug ICI-164384
CFAMM00240270 DNC006173 Investigative Drug N-methyl-N-ethyl estradiol-16-carboxamide
CFAMM00240268 DNC006157 Investigative Drug N-isopropyl estradiol-16-methyl carboxamide
CFAMM00240267 DNC006156 Investigative Drug N-methyl estradiol-16-methyl carboxamide
CFAMM00240266 DNC006155 Investigative Drug N-N-diethyl estradiol-16-methyl carboxamide
CFAMM00240265 DNC006154 Investigative Drug N-ethyl estradiol-16-methyl carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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