CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1490
Family Name High affinity nerve growth factor receptor and RAF proto-oncogene serine/threonine-protein kinase Inhibitor GW-5074 Family
No. of Seeds 3 No. of Other Members 29
Family Centroid CFAMM00240337 Functional Category Investigative Drug with Natural Product
Superfamily High affinity nerve growth factor receptor and RAF proto-oncogene serine/threonine-protein kinase Inhibitor GW-5074 Superfamily
Class Class 2132

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Cyclooxygenase Inhibitor Acetaminophen Family 2 42
Prostaglandin G/H synthase 2 Inhibitor Mefenamic Acid Family 7 137
Histamine H1 receptor Ligand Tranilast Family 5 125
Tyrosine-protein phosphatase non-receptor type 1 Ligand 2-(oxa... 3 11
Oestrogen receptor and Estrogen receptor beta Ligand 2-(4-hydr... 10 17
MO15-related protein kinase Pfmrk Inhibitor 3-[3-(2-hydroxy-et... 1 6
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Oestrogen receptor and Estrogen receptor beta Ligand 4-bromo-2... 3 0
Epidermal growth factor receptor Ligand 4-acrylamido-n-(3-brom... 2 20
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(3-hydroxyphenyl)... 3 9
Transient receptor potential cation channel subfamily V member... 2 29
Macrophage migration inhibitory factor Inhibitor 2-(4-hydroxys... 8 19
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 3 8
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 5 3
Serine/threonine-protein kinase Chk1 inhibitor N-[2-(dimethyla... 8 4
Hepatocyte growth factor receptor ligand N'-(4-chloro-2-oxoind... 2 27
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C8 liga... 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor A... 2 2
Hepatocyte growth factor receptor ligand N'-(5-bromo-2-oxoindo... 3 1
G-protein coupled receptor 55 and Cannabinoid receptor 1 ligan... 1 1
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 5 0
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0
Amino Acids and Derivatives Metabolite 5-Hydroxy-N-formylkynur... 3 3
Phenols and Derivatives Metabolite Methyl 2,3-dihydro-3,5-dihy... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00240338 CHEMBL264949 Bioactive (3E)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one
CFAMM00240325 DNC010328 Investigative Drug (E)-3-(4-hydroxybenzylidene)indolin-2-one
CFAMM00240337 DNC004633 Investigative Drug GW-5074

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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