CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1492
Family Name Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family
No. of Seeds 14 No. of Other Members 103
Family Centroid CFAMM00240410 Functional Category Investigative Drug with Natural Product
Superfamily Cyclin-dependent kinase 1 Inhibitor CGP-60474 Superfamily
Class Class 1504

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Alpha-2A adrenergic receptor Ligand Brimonidine Family 3 6
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Histamine H1 receptor Ligand Mizolastine Family 14 603
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Transient receptor potential cation channel subfamily V member... 6 66
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor PF-0048... 2 13
Amg 423 family 7 47
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
GDC-0349 family 44 77
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
PF-4217903 family 14 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Histamine H3 receptor Ligand SCH79687 Family 11 29
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Peptide deformylase, mitochondrial Inhibitor 5-chloryl-2,4,6-q... 2 6
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Aromatase Inhibitor NSC-356781 Family 3 10
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Sodium channel protein type 1 subunit alpha and Sodium channel... 1 2
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Metabotropic glutamate receptor 5 Ligand 2-methyl-7-m-tolyl-1,... 5 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Metabotropic glutamate receptor 5 Ligand 2-(3-bromophenyl)-7-m... 3 1
Metabotropic glutamate receptor 5 Ligand 5-(2-(3-chlorophenyl)... 2 13
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Adenosine kinase inhibitor abt-702 family 14 1
Prothrombin inhibitor SureCN5856722 family 3 16
Somatostatin receptor type 4 and Glucosylceramidase ligand MLS... 1 16
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 25 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Deoxycytidine kinase inhibitor AGN-PC-07Z9B3 family 2 7
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Aurora kinase A inhibitor AGN-PC-07ZZEH family 2 4
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
cGMP-specific 3',5'-cyclic phosphodiesterase and Potassium vol... 13 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
Platelet-activating factor receptor ligand SureCN9383514 family 4 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Adenosine kinase inhibitor 5-[3-(3-bromophenyl)propyl]-6-[2-(6... 3 0
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
Transient receptor potential cation channel subfamily V member... 1 0
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Epidermal growth factor receptor ligand AGN-PC-076GVG family 8 1
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Epidermal growth factor receptor ligand AGN-PC-076GXM family 6 0
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Sorbitol dehydrogenase inhibitor SureCN6335187 family 2 6
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 2
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor AC1LAKQL family 3 1
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Dihydrofolate reductase inhibitor AC1LAKWV family 2 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
D(4) dopamine receptor and D(2) dopamine receptor ligand N-(1-... 2 6
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlo... 11 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 1 4
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 11 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 9 3
ALK tyrosine kinase receptor and Insulin receptor ligand N-[(1... 3 6
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Corticotropin-releasing factor receptor 1 ligand 8-[butyl(ethy... 2 6
Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8... 7 1
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Ribosomal protein S6 kinase alpha-5 inhibitor AGN-PC-075HAD fa... 2 0
Vascular endothelial growth factor receptor 2 ligand urea deri... 2 0
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
Transient receptor potential cation channel subfamily V member... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Vascular endothelial growth factor receptor 2 and Fibroblast g... 5 2
Cyclin-dependent kinase 1 inhibitor 4-[[4-(3H-benzimidazol-5-y... 1 0
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Adenosine kinase inhibitor SureCN8320660 family 7 2
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Mitogen-activated protein kinase kinase kinase 8 and Dual spec... 1 0
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Transient receptor potential cation channel subfamily V member... 4 0
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 0
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0074... 2 3
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Transient receptor potential cation channel subfamily V member... 4 0
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 5 0
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Smoothened homolog inhibitor N-[4-chloro-3-(5-phenyl-1H-imidaz... 4 1
Cyclin-dependent kinase 2 and MAP kinase-activated protein kin... 3 0
Sigma non-opioid intracellular receptor 1 ligand 1-(3,4-dichlo... 2 19
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 4 8
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Adenosine kinase inhibitor 5-(4-bromophenyl)-6-[2-[4-(dimethyl... 1 0
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Tyrosine-protein kinase receptor TYRO3 and P-selectin ligand 2... 2 3
Tyrosine-protein kinase receptor TYRO3 and Mitogen-activated p... 3 7
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN1298914... 3 0
Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1... 1 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Cathepsin K inhibitor SureCN4141224 family 3 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Cathepsin K and Cathepsin L1 inhibitor 5-[3-(3,4-dihydro-1H-is... 2 0
Neuropeptide Y receptor type 5 ligand SureCN6835211 family 1 2
Epidermal growth factor receptor ligand AGN-PC-076GWD family 2 0
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 14 14
Epidermal growth factor receptor ligand AGN-PC-078X7L family 4 0
Dihydrofolate reductase inhibitor 5-[4-[(3,4-dichlorophenyl)me... 1 0
Epidermal growth factor receptor ligand (E)-N-[4-(3-bromoanili... 2 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03IU3J family 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 0
Adenosine kinase inhibitor SureCN8248615 family 2 3
Coagulation factor X inhibitor SureCN1652469 family 2 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand (E)-1... 1 2
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... 2 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Epidermal growth factor receptor ligand 4-Anilinopyrido[3,4-d]... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 2 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Prostaglandin E synthase inhibitor AGN-PC-014WPB family 1 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 2 1
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 14
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 3
Rho-associated protein kinase 1 inhibitor AGN-PC-07COKD family 1 0
Dihydrofolate reductase type 1 and Dihydrofolate reductase inh... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R96X family 7 1
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
Cannabinoid receptor 1 ligand AGN-PC-07R6NY family 2 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Dihydrofolate reductase inhibitor 5-[(7-chloro-10-methylsulfan... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Fibroblast growth factor receptor 1 and Proto-oncogene tyrosin... 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 3 3
Transcription factor AP-1 and Nuclear factor NF-kappa-B p105 s... 2 4
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 0
Nitric oxide synthase, inducible inhibitor N-(3-chlorophenyl)-... 1 0
Cannabinoid receptor 2 ligand SureCN13503317 family 7 7
Vascular endothelial growth factor receptor 2 and Cyclin-depen... 1 1
Serine/threonine-protein kinase Chk1 inhibitor N'-(8-chloro-3-... 1 1
1-acyl-sn-glycerol-3-phosphate acyltransferase beta inhibitor ... 3 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 4-N-[... 16 21
Cannabinoid receptor 2 ligand 4-[6-(2,3-dichlorophenyl)-1,2,4-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00240457 CHEMBL166154 Bioactive PD158780 Analog 7b
CFAMM00240473 CHEMBL147256 Bioactive AC1LAKPG
CFAMM00240492 CHEMBL120984 Bioactive 5-[[(2-chlorophenyl)methyl-methylamino]methyl]-6-[2-(6-morpholin-4-ylpyridin-3-yl)ethynyl]pyrimidin-4-amine
CFAMM00240388 CHEMBL270849 Bioactive N-(3-chlorophenyl)-4-(3-piperazin-1-ylphenyl)pyrimidin-2-amine
CFAMM00240395 CHEMBL347974 Bioactive AC1LAKPS
CFAMM00240512 CHEMBL147124 Bioactive AC1LAKPM
CFAMM00240477 CHEMBL2375757 Bioactive AGN-PC-077VTY
CFAMM00240505 CHEMBL177688 Bioactive Pyrazine-Pyridine Biheteroaryl 7
CFAMM00240446 CHEMBL446019 Bioactive N-[4-(3-chloroanilino)pyrido[4,3-d]pyrimidin-7-yl]prop-2-enamide
CFAMM00240510 CHEMBL225672 Bioactive 5-(4-chlorophenyl)-6-[2-[6-[2-methoxyethyl(methyl)amino]pyridin-3-yl]ethynyl]pyrimidin-4-amine
CFAMM00240410 DNC004640 Investigative Drug CGP-60474

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48682 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543