CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1495
Family Name Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-[5-bromo-indan-(1e)-ylidenemethyl]-1h-imidazole Family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00240529 Functional Category Investigative Drug
Superfamily Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-[5-bromo-indan-(1e)-ylidenemethyl]-1h-imidazole Superfamily
Class Class 177

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Farnesyltransferase beta subunit, putative Inhibitor BMS214662... 11 65
Telomerase protein component 1 Inhibitor GRN163L Family 5 29
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Histamine H3 receptor Ligand Proxyfan Family 12 32
Histamine H3 receptor Ligand SCH79687 Family 11 29
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-aminobenzyl... 3 6
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 6 6
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 2 8
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Histamine H3 receptor and Histamine H2 receptor ligand SureCN7... 2 2
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(2,4-difluor... 5 0
Histamine H4 receptor and Histamine H3 receptor ligand AGN-PC-... 1 2
Cytochrome P450 11B1, mitochondrial and Aromatase inhibitor (1... 1 0
Alpha-1A adrenergic receptor ligand 2-[4-(methylsulfonylmethyl... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00240529 DNC004645 Investigative Drug 5-[5-Bromo-indan-(1E)-ylidenemethyl]-1H-imidazole
CFAMM00240528 DNC004646 Investigative Drug 5-[5-Bromo-indan-(1Z)-ylidenemethyl]-1H-imidazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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