CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1503
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 2A Ligand A-80426 Family
No. of Seeds 8 No. of Other Members 66
Family Centroid CFAMM00240915 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 2A Ligand A-80426 Superfamily
Class Class 769

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Histamine H3 receptor Ligand ABT-239 Family 8 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Histamine H3 receptor Ligand A-349821 Family 49 228
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 4 18
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Melatonin receptor type 1A and Melatonin receptor type 1B Liga... 33 98
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 5 11
Fatty-acid amide hydrolase 1 Inhibitor Furan-2-ylmethylcarbami... 1 105
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 2
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 62
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 8 36
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 3 2
Sodium-dependent dopamine transporter and Sigma non-opioid int... 7 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 2 1
Kappa-type opioid receptor ligand 2-(1-benzofuran-4-yl)-N-meth... 4 5
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 2 2
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Lethal(3)malignant brain tumor-like protein 1 and Lysine-speci... 1 6
D(3) dopamine receptor ligand S 14297 family 1 2
Histamine H3 receptor ligand SureCN2786002 family 8 3
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Histamine H3 receptor ligand SureCN2784769 family 12 2
Histamine H3 receptor ligand SureCN2785131 family 7 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Mu-type opioid receptor ligand AGN-PC-075GAW family 2 1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Sigma no... 2 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Histamine H3 receptor ligand 2-(3,3-difluoropyrrolidin-1-yl)-1... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-074... 5 4
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 2
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 2 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
5-hydroxytryptamine receptor 1A ligand 8-[4-[[(2R)-5-fluoro-8-... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (6aR)... 1 0
Multidrug resistance protein 1 inhibitor 1-[4-[(2R)-2-hydroxy-... 1 0
Naphthofurans Metabolite Pyrocurzerenone Family 1 9
Putative NP ZINC02099241 Family 12 0
Putative NP ZINC02134473 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00240932 CHEMBL131449 Bioactive (2S)-8-(furan-2-yl)-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine
CFAMM00240989 CHEMBL337049 Bioactive (2R)-8-(furan-2-yl)-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine
CFAMM00240988 CHEMBL10102 Bioactive 2-(1-benzofuran-5-yl)-N-[[(1R)-5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]methyl]-N-methylethanamine
CFAMM00240928 CHEMBL328107 Bioactive CHEMBL328107
CFAMM00240956 CHEMBL314548 Bioactive AGN-PC-074PUF
CFAMM00240948 CHEMBL10068 Bioactive 2-(1,3-benzodioxol-5-yl)-N-methyl-N-[[(6R)-6,7,8,9-tetrahydrobenzo[g][1]benzofuran-6-yl]methyl]ethanamine
CFAMM00240915 DNC004664 Investigative Drug A-80426

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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