CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1515
Family Name Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-[5-methoxy-indan-(1e)-ylidenemethyl]-pyridine Family
No. of Seeds 12 No. of Other Members 3
Family Centroid CFAMM00241281 Functional Category Investigative Drug
Superfamily Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-[5-methoxy-indan-(1e)-ylidenemethyl]-pyridine Superfamily
Class Class 1129

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Citric Acid family 2 58
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Apricoxib family 8 77
PF-02545920 family 16 140
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 5 23
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Platelet-derived growth factor receptor alpha and Platelet-der... 6 8
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Histamine H1 receptor and Potassium voltage-gated channel subf... 3 1
Leukotriene B4 receptor 1 ligand AGN-PC-04XM3V family 3 10
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 6 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 4
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
Reverse transcriptase/RNaseH inhibitor AC1MHDM5 family 2 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 18
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Endothelin-1 receptor ligand SureCN8118632 family 4 5
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Proteinase-activated receptor 1 ligand (3R,3aR,4S,5R,6S,7aS)-5... 2 3
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Corticotropin-releasing factor receptor 1 ligand 8-(2-chloro-4... 13 1
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
Beta-secretase 1 inhibitor CHEMBL2152919 family 1 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 1
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 6 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Transient receptor potential cation channel subfamily V member... 6 1
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
Neuropeptide Y receptor type 5 ligand AGN-PC-040NYD family 3 7
Renin inhibitor SureCN6042213 family 2 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor N-[4... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Glucocorticoid receptor ligand SureCN3894124 family 3 0
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase inhibitor 1-... 1 3
Sodium-dependent serotonin transporter inhibitor SureCN5878703... 4 5
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Renin inhibitor SureCN7300793 family 2 5
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
Bile acid receptor ligand pyridin-4-yl (1R,3aS,5aR,5bR,7aR,9S,... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Nuclear receptor ROR-gamma and Induced myeloid leukemia cell d... 1 1
Farnesyl pyrophosphate synthase inhibitor [phosphono-[[4-(4-pr... 6 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
3-(4-methoxyphenyl)-1-pyrrol-1-ylpropan-1-one NP Agn-pc-08zsfd... 1 1
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0
(E)-3-(2-hydroxyphenyl)-1-pyridin-4-ylprop-2-en-1-one NP (e)-3... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00241292 DNC004693 Investigative Drug 3-[5-Ethoxy-indan-(1E)-ylidenemethyl]-pyridine
CFAMM00241284 DNC005621 Investigative Drug 4-[6-Methoxy-indan-(1E)-ylidenemethyl]-pyridine
CFAMM00241291 DNC004694 Investigative Drug 3-[5-Ethoxy-indan-(1Z)-ylidenemethyl]-pyridine
CFAMM00241283 DNC005622 Investigative Drug 4-[6-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine
CFAMM00241290 DNC004704 Investigative Drug 3-[7-Methoxy-indan-(1E)-ylidenemethyl]-pyridine
CFAMM00241282 DNC004688 Investigative Drug 3-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine
CFAMM00241296 DNC004717 Investigative Drug 4-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine
CFAMM00241281 DNC004687 Investigative Drug 3-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine
CFAMM00241295 DNC004716 Investigative Drug 4-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine
CFAMM00241286 DNC006351 Investigative Drug 3-(5-methoxy-1H-inden-2-yl)pyridine
CFAMM00241293 DNC004692 Investigative Drug 3-[6-Methoxy-indan-(1E)-ylidenemethyl]-pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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