CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1518
Family Name Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-[4-chloro-indan-(1e)-ylidenemethyl]-pyridine Family
No. of Seeds 2 No. of Other Members 11
Family Centroid CFAMM00241430 Functional Category Investigative Drug
Superfamily Histamine H1 receptor ligand tricyclic antidepressant Superfamily
Class Class 88

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Farnesyl pyrophosphate synthase Inhibitor Risedronate Family 4 28
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
G protein-activated inward rectifier potassium channel 4 Ligan... 3 48
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor Cycl... 1 0
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Plasminogen and Tissue-type plasminogen activator Inhibitor N-... 1 5
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Cytochrome P450 11B1, mitochondrial Inhibitor 3-(6-bromo-napht... 1 1
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... 6 32
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Farnesyl pyrophosphate synthase Inhibitor Piridronic Acid Family 3 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Cathepsin S Inhibitor 6-(3-(trifluoromethyl)phenyl)picolinonit... 7 2
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Fatty-acid amide hydrolase 1 Inhibitor 6-fluoropyridin-3-ylbor... 1 2
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Histamine H1 receptor and Potassium voltage-gated channel subf... 5 5
Acetylcholine receptor subunit delta ligand Guanidine, N-[(6-c... 2 15
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SQ6 family 3 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 5 3
Geranylgeranyl pyrophosphate synthase and Farnesyl pyrophospha... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 8 0
Neuronal acetylcholine receptor subunit alpha-6 ligand AGN-PC-... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 10 1
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Thymidylate synthase inhibitor AGN-PC-00EUGY family 2 7
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Corticotropin-releasing factor receptor 1 ligand 2-(2,4-dichlo... 2 2
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 1 0
Cytochrome P450 3A4 inhibitor N-[2-fluoro-4-(4-fluorophenyl)ph... 2 1
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 1 5
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0
Pyridines and Derivatives Metabolite (S)-Actinidine Family 1 0
NP 3-((1-(3-(2-(pyridin-3-yl)piperidin-1-yl)prop-1-yn-1-yl)cyc... 12 0
Putative NP ZINC38570085 Family 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00241430 DNC004702 Investigative Drug 3-[4-Chloro-indan-(1E)-ylidenemethyl]-pyridine
CFAMM00241429 DNC004703 Investigative Drug 3-[4-Chloro-indan-(1Z)-ylidenemethyl]-pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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