CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1531
Family Name DNA-dependent protein kinase catalytic subunit Inhibitor 7-propoxy-2-(morpholin-4-yl)-chromen-4-one Family
No. of Seeds 5 No. of Other Members 49
Family Centroid CFAMM00241688 Functional Category Investigative Drug with Natural Product
Superfamily Muscarinic acetylcholine receptor Ligand Flavoxate Superfamily
Class Class 288

Cousin Family NamesSeedsMembers
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Ipriflavone family 62 2480
Agrimophol family 10 22
Cyclin-dependent kinase 2 Inhibitor Flavopiridol Family 4 124
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Acolbifene family 10 115
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Endothelin B receptor and Endothelin-1 receptor Ligand PD-1631... 9 13
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor 2-[3-[(1R... 9 46
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 1 16
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-074... 5 4
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Prelamin... 1 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 2 1
Lanosterol synthase inhibitor AC1L9UWE family 1 0
Squalene--hopene cyclase and Lanosterol synthase inhibitor R17... 1 22
Cholesteryl ester transfer protein inhibitor [8-[(1S)-1-hydrox... 4 10
Reverse transcriptase/RNaseH inhibitor AC1O5COS family 1 0
Cathepsin D inhibitor (E)-N-butyl-4-[1-(3,4,5-trimethoxybenzoy... 1 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 7
Estrogen receptor ligand AGN-PC-073KIM family 1 0
Putative NP ZINC08790414 Family 23 0
NP (z)-2-(4-isopropylbenzylidene)-3-oxo-2,3-dihydrobenzofuran-... 16 0
2-amino-3-methylpentanoate NP 2-((3-(4-fluorophenoxy)-4-oxo-4h... 13 2
Putative NP ZINC08878071 Family 9 2
Putative NP ZINC00174842 Family 4 0
NP 4-(((3-(4-chlorophenyl)-2-methyl-4-oxo-4h-chromen-7-yl)oxy)... 14 0
NP Molport-006-318-109 Family 13 0
NP 3-(4-methoxyphenoxy)-4-oxo-4h-chromen-7-yl 4-bromobenzoate ... 13 0
Putative NP ZINC04085259 Family 3 0
4-(7-((2-amino-3-phenylpropanoyl)oxy)-5-hydroxy-4-oxo-4H-chrom... 3 0
NP (z)-2-((2-methyl-2h-chromen-3-yl)methylene)-3-oxo-2,3-dihyd... 74 1
NP Ethyl 4-(2-((5-hydroxy-2,2-dimethyl-4-oxochroman-7-yl)oxy)a... 4 0
NP 5-hydroxy-4-oxo-2-phenyl-4h-chromen-7-yl 2-((tert-butoxycar... 19 0
4-oxochromene-2-carboxylate NP Ethyl 3-(7-(2-(4-bromophenyl)-2... 10 1
NP 7-(2-((4as,8as)-4a-hydroxyoctahydroisoquinolin-2(1h)-yl)-2-... 3 0
orobenzoate NP 3-(2-methoxyphenyl)-2-methyl-4-oxo-4h-chromen-7... 22 0
hydroxyspiro[3H-chromene-2,4'-piperidine]-4-one NP 1'-acetyl-7... 2 1
ethylcarbamate NP ZINC09486061 Family 3 0
NP Agn-pc-05g5on Family 11 0
NP 3-(4-chlorophenyl)-4-oxo-4h-chromen-7-yl Diethylcarbamate F... 6 0
Putative NP ZINC02424323 Family 24 0
Putative NP ZINC02424496 Family 5 0
9,10-dihydro-8H-pyrano[2,3-f][1,3]benzoxazin-9-ium-2-one NP Ag... 6 0
NP 2-amino-7-[(2,6-dichlorophenyl)methoxy]-3-(4-methoxyphenyl)... 4 0
Putative NP ZINC09192007 Family 4 0
bromobenzoate NP ZINC11865066 Family 6 0
4-carboxylate NP ZINC04340771 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00241696 DNC005968 Investigative Drug 7-ethyloxyethoxy-2-morpholin-4-yl-chromen-4-one
CFAMM00241689 DNC005970 Investigative Drug 7-benzoyloxy-2-(morpholin-4-yl)-chromen-4-one
CFAMM00241688 DNC005972 Investigative Drug 7-propoxy-2-(morpholin-4-yl)-chromen-4-one
CFAMM00241668 DNC004795 Investigative Drug 7-Methoxy-2-morpholin-4-yl-chromen-4-one
CFAMM00241674 DNC005951 Investigative Drug 7-hydroxy-2-(morpholin-4-yl)chromen-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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