CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1535
Family Name Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic Acid Biphenyl-2-ylamide Family
No. of Seeds 4 No. of Other Members 14
Family Centroid CFAMM00241754 Functional Category Investigative Drug with Natural Product
Superfamily Pan-DAC Inhibitor AR-42 Superfamily
Class Class 1266

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Androgen receptor ligand aniline derivative Flutamide Family 3 9
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Voltage-gated sodium channel Ligand Oxcarbazepine Family 1 4
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Cholesterol side-chain cleavage enzyme, mitochondrial and Arom... 9 26
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Serum albumin Inhibitor Ebselen Family 3 62
Dual specificity mitogen-activated protein kinase kinase Inhib... 5 13
Motilin receptor Ligand GSK962040 Family 30 457
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Fumarate reductase flavoprotein subunit Inhibitor 2-heptyl-4-h... 3 16
Proto-oncogene tyrosine-protein kinase Src Inhibitor ISO24 Family 3 9
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor N-(4-s... 12 92
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Potassium voltage-gated channel subfamily A member 5 Ligand N-... 8 32
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Histone Deacetylase 8 Inhibitor 6-(2-mercaptoacetamido)-n-phen... 4 8
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Transient receptor potential cation channel subfamily V member... 6 33
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 1 9
Androgen receptor Ligand 6-n-propyl -4-trifluoromethylquinolin... 29 13
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 1 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Transient receptor potential cation channel subfamily V member... 1 5
Progesterone receptor Ligand 3-(3,3-dimethyl-2-oxoindolin-5-yl... 2 10
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor Benz... 3 12
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmaleimid... 2 11
Neutrophil elastase Inhibitor 3-butyl-3-ethyl-1-phenylazetidin... 6 5
Metabotropic glutamate receptor 5 Ligand N-(3-acetamidophenyl)... 4 20
Cruzipain Inhibitor N1,n4-bis(5-chloro-2-methylphenyl)succinam... 1 5
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 9 7
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 9h-bet... 1 1
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 8 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
Tyrosinase Inhibitor S-2-(o-toluidino)-2-oxoethyl Carbamothioa... 1 1
Histone Deacetylase 8 Inhibitor S-2,9-dioxo-9-(phenylamino)non... 1 0
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(3-cyanophe... 7 5
DNA topoisomerase Inhibitor 6-p-tolylamino-1h-pyrimidine-2,4-d... 3 17
DNA topoisomerase Inhibitor 6-(naphthalen-2-ylamino)-1h-pyrimi... 2 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Lethal factor inhibitor (2R)-6-[(4-chlorophenyl)methylamino]-2... 3 0
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 2 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Cellular tumor antigen p53 inhibitor CHEMBL1554992 family 1 0
Neprilysin inhibitor AGN-PC-047EOR family 2 3
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Ribosyldihydronicotinamide dehydrogenase [quinone] and Melaton... 1 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
Kappa-type opioid receptor ligand N-methyl-N-[(1S)-2-pyrrolidi... 3 17
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
Transient receptor potential cation channel subfamily V member... 9 38
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Transient receptor potential cation channel subfamily V member... 1 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Tankyrase-2 inhibitor 7-(2-chlorophenyl)-4-methyl-1H-quinolin-... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Histamine receptor H3 ligand N-[2-methyl-4-[(3S)-3-[(2S)-2-met... 10 7
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 7 ligand 2-[4-[4-(2-oxo-1,3,4,5-t... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Chitin synthase 1 inhibitor AC1O53V7 family 9 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Dipeptidyl peptidase 4 inhibitor 4-[[(3S,5S)-5-[(2S)-2-cyanopy... 4 12
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Collagenase 3 and Interstitial collagenase inhibitor (2R,3S)-N... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 3 2
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Progesterone receptor ligand SureCN3525721 family 1 2
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
Progesterone receptor ligand AGN-PC-048NI9 family 1 5
P2X purinoceptor 7 inhibitor N'-(2-methylphenyl)adamantane-1-c... 3 0
Acyl-CoA:cholesterol acyltransferase inhibitor N-[2,6-di(propa... 1 2
Transient receptor potential cation channel subfamily A member... 1 0
Voltage-dependent L-type calcium channel subunit alpha-1S liga... 1 0
Metabotropic glutamate receptor 2 ligand 4-[4-(methylamino)phe... 1 4
G protein-activated inward rectifier potassium channel 4 and G... 1 0
Lysophosphatidic acid receptor 3 and Microtubule-associated pr... 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-073NSD f... 1 0
Substance-P receptor ligand AGN-PC-01XQZB family 1 0
Progesterone receptor ligand AGN-PC-00PB7N family 2 1
Aromatic Heteropolycyclic Compounds Metabolite 1-Methoxyspirob... 2 0
Putative NP ZINC00209326 Family 4 0
3-prop-2-enyl-1H-quinolin-4-one NP 6-amino-2-methylquinolin-4-... 5 3
7-(4-methylpent-3-enylidene)-3-phenyl-2,4a,5,6,8,8a-hexahydrop... 6 0
2-(6-methyl-2-oxo-4-phenyl-1H-quinolin-3-yl)acetate NP ZINC002... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00241777 DNC004809 Investigative Drug 7-Mercapto-heptanoic acid biphenyl-4-ylamide
CFAMM00241754 DNC008313 Investigative Drug octanoic acid biphenyl-2-ylamide
CFAMM00241775 DNC008314 Investigative Drug nonanoic acid biphenyl-2-ylamide
CFAMM00241772 DNC004810 Investigative Drug 7-Mercapto-heptanoic acid biphenyl-3-ylamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27256 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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