CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1539
Family Name 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Ligand 3-(4-benzyl-piperidin-1-ylmethyl)-chroman-4-one Family
No. of Seeds 2 No. of Other Members 14
Family Centroid CFAMM00241955 Functional Category Investigative Drug with Natural Product
Superfamily Muscarinic acetylcholine receptor Ligand Flavoxate Superfamily
Class Class 288

Cousin Family NamesSeedsMembers
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Potassium voltage-gated channel subfamily H member 2 Ligand Am... 2 16
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Cocain... 13 136
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Ipriflavone family 62 2480
Cyclin-dependent kinase 2 Inhibitor Flavopiridol Family 4 124
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Histamine H3 receptor Ligand A-349821 Family 49 228
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 2
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 62
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 8 36
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 8
Sodium-dependent dopamine transporter and Sigma non-opioid int... 7 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 2 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 2 2
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 0
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
Lethal(3)malignant brain tumor-like protein 1 and Lysine-speci... 1 6
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Histamine H3 receptor ligand SureCN2786002 family 8 3
Histamine H3 receptor ligand SureCN2785131 family 7 1
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Sigma no... 2 4
Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[... 5 5
Histamine H3 receptor ligand 2-(3,3-difluoropyrrolidin-1-yl)-1... 2 0
Histamine H3 receptor ligand SureCN7244264 family 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 3 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Histamine H1 receptor and Cysteinyl leukotriene receptor 1 lig... 1 15
Sodium- and chloride-dependent GABA transporter 1 inhibitor (3... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 2 1
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 2 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 7
oxybenzoate NP ZINC04029407 Family 4 1
Putative NP ZINC00174842 Family 4 0
hydroxyspiro[3H-chromene-2,4'-piperidine]-4-one NP 1'-acetyl-7... 2 1
Putative NP ZINC04028664 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00241955 DNC004823 Investigative Drug 3-(4-Benzyl-piperidin-1-ylmethyl)-chroman-4-one
CFAMM00241954 DNC007378 Investigative Drug ISOELAEOCARPINE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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