CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1540
Family Name Cytochrome P450 3A4 Inhibitor 3-(3-methylthiophen-2-yl)pyridine Family
No. of Seeds 5 No. of Other Members 27
Family Centroid CFAMM00241982 Functional Category Investigative Drug
Superfamily Cytochrome P450 3A4 and Cytochrome P450 11B1, mitochondrial Binder Superfamily
Class Class 1800

Cousin Family NamesSeedsMembers
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Thromboxane A2 receptor Ligand Ridogrel Family 7 83
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Urokinase-type plasminogen activator Inhibitor Thieno[2,3-b]py... 1 12
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
Metabotropic glutamate receptor 5 Ligand 2-methyl-4-(pyridin-3... 10 35
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
D(2) dopamine receptor Ligand PD-135146 Family 5 11
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Histamine H1 receptor and Cytochrome P450 2D6 ligand 2-[3-[(1R... 1 10
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 8 5
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 3 7
Histamine H1 receptor and Cytochrome P450 2D6 ligand N-methyl-... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 4 11
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 8 6
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 2
Metabotropic glutamate receptor 5 and Cytochrome P450 1A2 liga... 2 1
Arachidonate 5-lipoxygenase inhibitor AGN-PC-073JGI family 1 0
Glutamate racemase inhibitor (5Z)-N-methyl-5-pyrrol-3-ylidene-... 2 0
5-phenyl-1,3-thiazole NP 5-phenylthiazole Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00241962 CHEMBL97302 Bioactive SureCN9466973
CFAMM00241986 DNC004832 Investigative Drug Methyl-(5-pyridin-3-yl-thiophen-2-yl)-amine
CFAMM00241984 DNC006938 Investigative Drug 2-fluoro-5-(3-methylthiophen-2-yl)pyridine
CFAMM00241982 DNC004856 Investigative Drug 3-(3-methylthiophen-2-yl)pyridine
CFAMM00241981 DNC004858 Investigative Drug 5-Pyridin-3-yl-thiophene-2-carbaldehyde oxime

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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