CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1543
Family Name Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 11B1, mitochondrial Inhibitor 4-(4-(thiophen-2-yl)benzyl)pyridine Family
No. of Seeds 7 No. of Other Members 16
Family Centroid CFAMM00242110 Functional Category Investigative Drug
Superfamily Cytochrome P450 3A4 and Cytochrome P450 11B1, mitochondrial Binder Superfamily
Class Class 1800

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Histamine H1 receptor Ligand Pheniramine Family 10 380
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Rho-associated protein kinase 1 Inhibitor Rho-kinase Inhibitor... 6 39
Urokinase-type plasminogen activator Inhibitor Thieno[2,3-b]py... 1 12
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
Cytochrome P450 3A4 Inhibitor 3-(3-methylthiophen-2-yl)pyridin... 5 27
Metabotropic glutamate receptor 5 Ligand 2-methyl-4-(pyridin-3... 10 35
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 12
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Histamine H3 receptor Ligand ST-1025 Family 2 22
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 20
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 14
Histamine H1 receptor and Cytochrome P450 2D6 ligand 2-[3-[(1R... 1 10
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 8
D(2) dopamine receptor and D(3) dopamine receptor ligand 8-chl... 6 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 3 7
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Histamine H1 receptor and Cytochrome P450 2D6 ligand N-methyl-... 1 0
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 8 6
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
Sodium-dependent serotonin transporter inhibitor 3-[[(3S)-1-az... 1 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 2
Metabotropic glutamate receptor 5 ligand 3-methyl-1-(2-thiophe... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 4
5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 4 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 1 0
Carbonic anhydrase 2 inhibitor AGN-PC-07C00G family 1 1
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Metabotropic glutamate receptor 5 and Cytochrome P450 1A2 liga... 2 1
5-phenyl-1,3-thiazole NP 5-phenylthiazole Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00242099 CHEMBL1093044 Bioactive SureCN4850294
CFAMM00242112 CHEMBL1091778 Bioactive SureCN4852438
CFAMM00242107 CHEMBL189936 Bioactive AGN-PC-075IIF
CFAMM00242105 DNC011109 Investigative Drug 4-(4-(thiophen-3-yl)benzyl)pyridine
CFAMM00242110 DNC011110 Investigative Drug 4-(4-(thiophen-2-yl)benzyl)pyridine
CFAMM00242100 DNC004860 Investigative Drug Bis-(5-pyridin-3-yl-thiophen-2-ylmethyl)-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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