CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID1545
Family Name Histamine H3 receptor Ligand A-349821 Family
No. of Seeds 49 No. of Other Members 228
Family Centroid CFAMM00242200 Functional Category Investigative Drug with Natural Product
Superfamily Caspase-3 and Histamine H3 receptor Binder Superfamily
Class Class 893

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Beta adrenergic receptor Ligand Levobunolol Family 6 133
D(2) dopamine receptor Ligand Sulpiride Family 7 38
D(2) dopamine receptor Ligand Remoxipride Family 12 84
Potassium voltage-gated channel subfamily H member 2 Ligand Am... 2 16
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Glucan synthesis regulatory protein Inhibitor Anidulafungin Fa... 2 5
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
HIV-1 protease Inhibitor Lopinavir Family 4 25
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
Zucapsacin family 7 177
Histamine H3 receptor Ligand ABT-239 Family 8 20
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Endothelin-1 receptor Ligand Atrasentan Family 127 336
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Histamine H1 receptor and Histamine H3 receptor Ligand GSK1004... 13 18
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Irdabisant family 49 53
Elagolix family 43 98
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Poly [ADP-ribose] polymerase 1 Inhibitor 3-methoxybenzamide Fa... 2 23
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
Scytalone dehydratase Inhibitor 5-fluoro-2-hydroxy-n-isopropyl... 3 14
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Histamine H1 receptor Ligand MDL-105212 Family 16 56
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 4 18
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Melatonin receptor type 1A and Melatonin receptor type 1B Liga... 33 98
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
Urotensin-2 receptor Ligand SB-328872 Family 5 24
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 3
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 14
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 5 11
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Fatty-acid amide hydrolase 1 Inhibitor Furan-2-ylmethylcarbami... 1 105
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 62
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Histamine H1 receptor and Arachidonate 5-lipoxygenase Ligand N... 5 6
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 2
Histamine H3 receptor and Histamine H2 receptor ligand N-[(3S)... 16 5
Pol polyprotein inhibitor 180968-31-4 family 8 13
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor 2-[3-[(1R... 9 46
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 4 7
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 2 3
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 1 1
Muscarinic acetylcholine receptor M2 ligand [4-[(3R)-4-[(1S)-1... 3 13
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Pyruvate kinase PKM and Pyruvate kinase PKLR inhibitor MLS0022... 1 0
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 5 4
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 3 2
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745OX family 2 0
Muscarinic acetylcholine receptor M2 ligand AGN-PC-074ITY family 16 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 2 1
Ectonucleotide pyrophosphatase/phosphodiesterase family member... 4 10
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Prothrombin inhibitor 3-[3-(diaminomethylideneamino)oxypropoxy... 6 3
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Prothrombin inhibitor N-cyclohexyl-3-[3-(diaminomethylideneami... 3 4
E3 ubiquitin-protein ligase XIAP inhibitor N-METHYLALANYL-3-ME... 3 14
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 0
D(2) dopamine receptor and D(3) dopamine receptor ligand 5-bro... 3 11
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
D(2) dopamine receptor ligand 2-chloro-3-ethyl-N-[[(2S)-1-ethy... 3 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 10
Survival motor neuron protein inhibitor CHEMBL1303282 family 1 1
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 2
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
Cellular tumor antigen p53 and Lysine-specific demethylase 4E ... 1 5
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
Lethal(3)malignant brain tumor-like protein 1 and Lysine-speci... 1 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1424193 family 1 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 4 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
Type-2 angiotensin II receptor ligand SureCN244657 family 7 11
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Histamine H3 receptor ligand SureCN2786002 family 8 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Rho-associated protein kinase 1 and Rho-associated protein kin... 1 7
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Pol polyprotein inhibitor CHEMBL305466 family 4 7
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
Prostaglandin E2 receptor EP4 subtype ligand SureCN5653729 family 3 2
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Histamine H1 receptor and Histamine H3 receptor ligand 4-[(4-m... 3 6
Histamine H3 receptor ligand SureCN2784769 family 12 2
Histamine H3 receptor ligand SureCN2785131 family 7 1
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-benzylsul... 2 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 6
Substance-P receptor ligand 3-[bis(4-fluorophenyl)methyl]-1-[(... 5 2
Sigma non-opioid intracellular receptor 1 and Vesicular acetyl... 3 7
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Histamine H3 receptor ligand SureCN1373218 family 2 2
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Histamine H3 receptor ligand 2-methyl-4-[4-(3-pyrrolidin-1-ylp... 4 1
Histamine H3 receptor ligand 3-methyl-1-[4-(3-piperidin-1-ylpr... 6 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Mu-type opioid receptor ligand AGN-PC-075GCP family 2 8
Mu-type opioid receptor ligand AGN-PC-075GAC family 16 8
Mu-type opioid receptor ligand AGN-PC-075GFE family 1 0
Mu-type opioid receptor ligand AGN-PC-075GG7 family 4 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Mu-type opioid receptor ligand AGN-PC-075GAW family 2 1
Melanin-concentrating hormone receptor 1 ligand (3S)-3-[[5-(4-... 4 5
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 6 1
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Histamine H3 receptor ligand 1-methyl-5-[4-[3-[(2R)-2-methylpy... 5 5
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Sigma no... 2 4
B1 bradykinin receptor ligand 4-(5-chloro-4-oxochromen-3-yl)-N... 1 5
Collagenase 3 and 72 kDa type IV collagenase inhibitor N-[(3,4... 1 6
Cytochrome P450 1A2 and Cytochrome P450 3A4 inhibitor 4-[4-[2-... 2 3
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 1 1
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 2 5
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 3 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 7 1
Pol polyprotein inhibitor MDL 74538 family 11 1
5-hydroxytryptamine receptor 3A ligand 5-[4-[3-(azepan-1-yl)pr... 2 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 3
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Histamine H3 receptor ligand 4-[[2-[2-[(2R)-2-methylpyrrolidin... 1 1
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 2 0
Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[... 5 5
Histamine H3 receptor ligand 2-(3,3-difluoropyrrolidin-1-yl)-1... 2 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Histamine H3 receptor ligand SureCN5218144 family 4 6
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 0
5-hydroxytryptamine receptor 1A ligand (3S)-3-[4-(7,9-dioxo-8-... 2 0
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-1-(3,5-d... 10 15
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoyl-5-methy... 1 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 6 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Beta-secretase 1 and Cathepsin B inhibitor N-[(2S)-1-[[(2S,3R)... 2 1
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 1 16
C-C chemokine receptor type 1 ligand [2-[(2S)-3-(5-chlorospiro... 3 0
C-C chemokine receptor type 1 ligand 2-[(2S)-3-(5-chlorospiro[... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 4
C-C chemokine receptor type 5 ligand 4-[4-[[4-[(5R)-3-cyclohex... 4 2
Estrogen receptor and Estrogen receptor beta ligand SureCN1450... 1 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 2
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 14 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 2 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 8 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand N-[... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Potassium voltage-gated channel subfamily H member 2 and C-C c... 2 1
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Pol polyprotein inhibitor AC1LA3AI family 5 9
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
Sigma non-opioid intracellular receptor 1 and D(3) dopamine re... 26 8
Histamine H3 receptor ligand SureCN7244264 family 1 0
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-074... 5 4
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Growth hormone secretagogue receptor type 1 ligand SureCN76477... 2 1
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(3,5-difluorophenyl)-3... 5 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04X9O... 2 1
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 2 4
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
Dipeptidyl peptidase 4 inhibitor SureCN5777647 family 1 0
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 3 1
Motilin receptor and Growth hormone secretagogue receptor type... 1 2
Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... 1 0
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Kappa-type opioid receptor ligand N-[(1S)-2-[(3S)-3-hydroxypyr... 2 0
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 1
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
C-C chemokine receptor type 3 ligand N-[(3R)-1-[(6-fluoronapht... 1 4
Protein kinase C theta type and Protein kinase C epsilon type ... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D inhibitor (4aS... 10 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 12
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-074LOQ... 3 0
Gonadotropin-releasing hormone receptor ligand N-[[4-[(diamino... 6 4
Arachidonate 5-lipoxygenase inhibitor methyl 5-[1-(2-butyl-1-b... 2 4
Capsid scaffolding protein inhibitor AC1LAC52 family 1 0
Metabotropic glutamate receptor 2 ligand SureCN787402 family 1 8
Neuromedin-K receptor ligand SureCN2478117 family 1 0
Trace amine-associated receptor 1 ligand SureCN13886619 family 1 1
Histamine H3 receptor ligand 3-[[(1S,4S)-5-[3-[4-(cyclopropane... 1 3
Sodium/hydrogen exchanger 1 inhibitor 4-(1-acetylpiperidin-4-y... 1 1
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 1 1
Histone deacetylase 3 and Histone deacetylase 6 inhibitor (E)-... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 1 5
Cathepsin K inhibitor benzyl N-[(2S)-4-methyl-1-oxo-1-[2-[[(4-... 2 0
C-C chemokine receptor type 2 ligand (E)-N-[(1S,3R)-3-[[4-(4-m... 1 6
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 2-ben... 1 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Oxysterols receptor LXR-alpha ligand Tertiary amine, 9 family 2 2
Collagenase 3 inhibitor ethyl 4-[4-[2-[(3S)-3-hydroxy-1-azabic... 1 0
Potassium voltage-gated channel subfamily A member 5 and Potas... 3 0
Multidrug resistance protein 1 inhibitor 1-[4-[(2R)-2-hydroxy-... 1 0
Reverse transcriptase/RNaseH inhibitor Thiazoloisoindol-5-one ... 1 2
Thyroid hormone receptor beta ligand 3-(4-acetylpiperazin-1-yl... 3 2
Putative NP ZINC02127056 Family 4 1
Putative NP ZINC20762875 Family 7 1
Putative NP ZINC04061066 Family 18 0
NP ((1r,4as,8as)-4a-hydroxy-1-(3,4,5-trimethoxyphenyl)octahydr... 3 3
oxybenzoate NP ZINC04029407 Family 4 1
Putative NP ZINC20611663 Family 4 0
2-(2,4-dimethoxyphenyl)-2,3,6,7,11,12-hexahydro-[1,4]dioxepino... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00242274 CHEMBL188206 Bioactive (3S)-3-[[4-(4-methoxyphenyl)benzoyl]-methylamino]-N-methyl-N-[(3R)-1-methylpyrrolidin-3-yl]pyrrolidine-1-carboxamide
CFAMM00242304 CHEMBL1923738 Bioactive 2-methyl-4-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]isoquinolin-1-one
CFAMM00242368 CHEMBL346562 Bioactive SureCN2806214
CFAMM00242410 CHEMBL67240 Bioactive AGN-PC-074EE6
CFAMM00242324 CHEMBL422893 Bioactive [4-[2-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]-1-benzofuran-5-yl]phenyl]-morpholin-4-ylmethanone
CFAMM00242303 CHEMBL1923737 Bioactive 1-methyl-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-3-phenylpyridin-2-one
CFAMM00242367 CHEMBL27979 Bioactive A-349821
CFAMM00242140 CHEMBL476099 Bioactive AGN-PC-00ADST
CFAMM00242153 CHEMBL557461 Bioactive AGN-PC-00CMJD
CFAMM00242265 CHEMBL2036648 Bioactive 2-[4-(4-fluorobenzoyl)piperazin-1-yl]-1-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]ethanone
CFAMM00242342 CHEMBL159617 Bioactive SureCN2785569
CFAMM00242240 CHEMBL345588 Bioactive [4-[2-[2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethyl]-1-benzofuran-5-yl]phenyl]-morpholin-4-ylmethanone
CFAMM00242320 CHEMBL184820 Bioactive AGN-PC-075GFA
CFAMM00242383 CHEMBL159565 Bioactive SureCN2785133
CFAMM00242398 CHEMBL67157 Bioactive SureCN6309650
CFAMM00242157 CHEMBL161130 Bioactive AGN-PC-00F9HA
CFAMM00242232 CHEMBL159519 Bioactive SureCN2784943
CFAMM00242195 CHEMBL94707 Bioactive Tertiary Amide deriv. 62
CFAMM00242222 CHEMBL161101 Bioactive SureCN2785716
CFAMM00242200 DNC004862 Investigative Drug A-349821

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27270 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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