CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1557
Family Name Metabotropic glutamate receptor 5 Ligand 2-methyl-4-(pyridin-3-ylethynyl)thiazole Family
No. of Seeds 10 No. of Other Members 35
Family Centroid CFAMM00242722 Functional Category Investigative Drug with Natural Product
Superfamily Metabotropic glutamate receptor 5 and Mitogen-activated protein kinase 14 Binder Superfamily
Class Class 1981

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
G protein-activated inward rectifier potassium channel 4 Ligan... 3 48
Urokinase-type plasminogen activator Inhibitor Thieno[2,3-b]py... 1 12
Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
Cytochrome P450 3A4 Inhibitor 3-(3-methylthiophen-2-yl)pyridin... 5 27
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Metabotropic glutamate receptor 5 Ligand N-[4-(3-pyridylethyny... 2 10
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Histamine H3 receptor Ligand ST-1025 Family 2 22
D(2) dopamine receptor Ligand PD-135146 Family 5 11
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 20
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 14
Histamine H1 receptor and Cytochrome P450 2D6 ligand 2-[3-[(1R... 1 10
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 8 5
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
Aromatase inhibitor 2-(2-chloropyridin-4-yl)-4-pyridin-3-yl-1,... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Metabotropic glutamate receptor 5 and Cytochrome P450 1A2 liga... 2 1
Arachidonate 5-lipoxygenase inhibitor AGN-PC-073JGI family 1 0
Azoles Metabolite 1H-Pyrrolo[2,1-c][1,4]thiazine Family 1 1
5-phenyl-1,3-thiazole NP 5-phenylthiazole Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00242730 CHEMBL332396 Bioactive SureCN11966068
CFAMM00242745 CHEMBL229962 Bioactive AGN-PC-0153HZ
CFAMM00242721 DNC006112 Investigative Drug 3-[(2-methyl-4-thiazolyl)ethynyl]-5-vinylpyridine
CFAMM00242720 DNC006111 Investigative Drug (E)-3-[2-(2-methyl-4-thiazolyl)vinyl]pyridine
CFAMM00242748 DNC005003 Investigative Drug 2-(2-Methyl-thiazol-4-ylethynyl)-pyridine
CFAMM00242717 DNC006119 Investigative Drug 3-[(5-ethyl-2-methyl-4-thiazolyl)ethynyl]pyridine
CFAMM00242747 DNC005004 Investigative Drug 4-(2-Methyl-thiazol-4-ylethynyl)-pyridine
CFAMM00242731 DNC006113 Investigative Drug 3-bromo-5-[(2-methyl-4-thiazolyl)ethynyl]pyridine
CFAMM00242722 DNC004898 Investigative Drug 2-methyl-4-(pyridin-3-ylethynyl)thiazole
CFAMM00242751 DNC006120 Investigative Drug 3-[(2,5-dimethyl-4-thiazolyl)ethynyl]pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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