CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1566
Family Name Substance-K receptor Ligand MEN-14933 Family
No. of Seeds 13 No. of Other Members 154
Family Centroid CFAMM00243270 Functional Category Investigative Drug with Natural Product
Superfamily Substance-K receptor Ligand MEN-14933 Superfamily
Class Class 1350

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Nemonapride Family 70 283
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
Integrin alpha-4 Inhibitor R1295 Family 18 59
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Cinitapride family 4 22
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Neuropeptide Y receptor type 1 Ligand BMS-193885 Family 3 11
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 7 5
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor Ligand Ro-11-04253 Family 1 1
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
Coagulation factor X Inhibitor BMS-269223 Family 15 58
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Neuropeptide Y receptor type 1 Ligand N-arylpiperazine Derivat... 13 22
Neuropeptide Y receptor type 1 Ligand N-arylpiperazine Derivat... 5 4
Integrin beta-1 and Integrin alpha-4 inhibitor (3S)-3-(3,4-dim... 5 61
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Stromelysin-1 and 72 kDa type IV collagenase inhibitor [(2S)-2... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 6
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
Disintegrin and metalloproteinase domain-containing protein 17... 3 0
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Kappa-type opioid receptor ligand AGN-PC-09M90I family 2 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-087THW family 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN2729784 family 3 9
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
Microsomal triglyceride transfer protein large subunit inhibit... 4 5
Renin inhibitor 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]pro... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 9 37
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-01ZLS4 family 2 8
Transient receptor potential cation channel subfamily V member... 3 15
Capsid scaffolding protein inhibitor AC1LAC6N family 2 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Disintegrin and metalloproteinase domain-containing protein 17... 3 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[... 5 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Survival motor neuron protein and Alpha-galactosidase A inhibi... 1 4
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2I family 3 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2K family 2 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Carbonic anhydrase 12 and Probable transmembrane carbonic anhy... 2 0
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Trace amine-associated receptor 1 ligand EPPTB family 4 9
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor N-[(1S,5aR,9... 2 2
Vasopressin V1b receptor ligand AGN-PC-09QGT9 family 4 123
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Peptide deformylase inhibitor 2-[(2R)-2-(cyclopentylmethyl)-3-... 3 2
Integrin beta-1 and Integrin alpha-4 inhibitor AGN-PC-02YIN5 f... 3 5
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Substance-P receptor ligand 1-[(5-amino-2-methoxyphenyl)methyl... 3 5
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-(4-methoxya... 1 26
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 2 1
Renin inhibitor 5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4... 5 9
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(4... 10 0
Melanin-concentrating hormone receptor 1 ligand 3-[4-fluoro-3-... 3 7
Furin inhibitor phenyl 2-[[(2S)-1-[[(2S)-1-[[(2S)-1-(4-carbami... 2 5
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 6 1
Melanocortin receptor 4 ligand 3-amino-N-[(2R)-3-(2,4-dichloro... 1 9
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Cathepsin S and Cathepsin K inhibitor SureCN3011598 family 1 11
Cathepsin S and Cathepsin K inhibitor SureCN3018173 family 2 4
C-C chemokine receptor type 3 ligand 1-[(3R)-1-[(6-fluoronapht... 2 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(1-cyanocyclop... 4 0
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 2 1
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 12 13
Bifunctional epoxide hydrolase 2 inhibitor SureCN3178516 family 3 1
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
5-hydroxytryptamine receptor 1B ligand SureCN5352760 family 2 5
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 3 11
Translocator protein inhibitor CHEMBL2332259 family 2 0
C-C chemokine receptor type 1 ligand N-[2-[(2S)-2-amino-3-(5-f... 3 0
Nociceptin receptor and Mu-type opioid receptor ligand SureCN7... 13 22
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 8
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand N-ethyl... 8 3
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 10
Bifunctional epoxide hydrolase 2 and RAF proto-oncogene serine... 4 10
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-ethylbutanoyl)... 11 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 5
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 20 23
C-X-C chemokine receptor type 3 ligand 1-[1-[(9-acetyl-9-azabi... 1 0
Alpha-1D adrenergic receptor and D(2) dopamine receptor ligand... 3 0
Neuropeptide Y receptor type 1 ligand SureCN8354018 family 2 2
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 7
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
Neprilysin and Angiotensin-converting enzyme inhibitor 2-[(3S)... 5 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 4 4
Neuropeptide Y receptor type 5 ligand 3-[4-(4-fluorophenoxy)ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
Substance-P receptor ligand CP 141938 family 1 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJY family 5 4
Prothrombin and Coagulation factor X inhibitor AGN-PC-04SR80 f... 5 24
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KFD family 1 1
Mitogen-activated protein kinase 14 inhibitor SureCN4822166 fa... 1 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
Hormone-sensitive lipase inhibitor [4-[(4-tert-butylcyclohexan... 2 1
Vasopressin V2 receptor ligand SureCN4206215 family 1 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Trypsin-1 inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethylam... 1 0
fMet-Leu-Phe receptor ligand 2-[[(2S)-2-[[(2S)-2-[(4-methoxyph... 1 0
Neuropeptide Y receptor type 1 ligand 1-(1-benzofuran-6-yl)-3-... 1 1
Sterol O-acyltransferase 1 inhibitor SureCN6152927 family 7 3
Histamine H3 receptor ligand AGN-PC-07ZCFA family 1 0
C-C chemokine receptor type 3 ligand SureCN6700764 family 2 2
Beta-1 adrenergic receptor and Beta-3 adrenergic receptor liga... 2 0
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
DNA polymerase III PolC-type inhibitor 6-(3-ethyl-4-methylanil... 1 0
Calcitonin gene-related peptide type 1 receptor ligand 2-(4-me... 4 4
Melanocortin receptor 4 ligand [4-[2-[(1S)-1-amino-3-methylbut... 1 0
Sodium channel protein type 9 subunit alpha ligand SureCN12900... 9 8
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 2 0
C-X-C chemokine receptor type 3 ligand 1-[1-[[(1S,5R)-6,6-dime... 2 3
Gonadotropin-releasing hormone receptor ligand CHEMBL260816 fa... 1 0
Matrix metalloproteinase-9 and Metalloproteinase inhibitor 3 i... 1 3
Proteinase-activated receptor 1 ligand 2-[[2-[[2-[acetyl-[(E)-... 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9818603 f... 2 2
Neuropeptide Y receptor type 5 ligand SureCN3380276 family 1 1
Cholinesterase inhibitor (13-methyl-5,6,8,13a-tetrahydroisoqui... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-[2-... 1 1
Sodium channel protein type 1 subunit alpha and Sodium channel... 3 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor [2,6-di(propan-... 1 0
Quinazolines Metabolite Dictyoquinazol B Family 2 1
4,4,6-trimethyl-1,3-dihydroimidazo[1,2-a]indol-2-one NP ZINC02... 37 0
8,10,10-trimethyl-3,4-dihydro-1H-pyrimido[1,2-a]indol-2-one NP... 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00243238 CHEMBL93401 Bioactive SureCN7416640
CFAMM00243302 CHEMBL91438 Bioactive SureCN7419209
CFAMM00243313 CHEMBL329286 Bioactive N-tert-butyl-2-[(3R,5S,7R)-3-[(4-methoxyphenyl)carbamoylamino]-5-(2-methylphenyl)-2-oxo-7-phenylazepan-1-yl]acetamide
CFAMM00243249 CHEMBL1631751 Bioactive (2R,3S)-3-benzyl-2-[4-(4-methylpiperazin-1-yl)phenoxy]-4-oxo-N-[(1R)-1-phenylethyl]azetidine-1-carboxamide
CFAMM00243299 CHEMBL379079 Bioactive SureCN13921072
CFAMM00243217 CHEMBL194601 Bioactive 1-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-(4-methoxyphenyl)urea
CFAMM00243274 CHEMBL1086821 Bioactive N-(2-morpholin-4-ylethyl)-4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]benzamide
CFAMM00243270 DNC004914 Investigative Drug MEN-14933

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22656 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543